Table of Contents

Articles

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  Stabilizers of the Max Homodimer Identified in Virtual Ligand Screening Inhibit Myc Function

  Hao Jiang, Kristen E. Bower, Albert E. Beuscher, Bin Zhou, Andrey A. Bobkov, Arthur J. Olson and Peter K. Vogt

  Molecular Pharmacology September 2009, 76 (3) 491-502; DOI: https://doi.org/10.1124/mol.109.054858
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  Hepatic CYP3A Suppression by High Concentrations of Proteasomal Inhibitors: A Consequence of Endoplasmic Reticulum (ER) Stress Induction, Activation of RNA-Dependent Protein Kinase-Like ER-Bound Eukaryotic Initiation Factor 2α (eIF2α)-Kinase (PERK) and General Control Nonderepressible-2 eIF2α Kinase (GCN2), and Global Translational Shutoff

  Poulomi Acharya, Juan C. Engel and Maria Almira Correia

  Molecular Pharmacology September 2009, 76 (3) 503-515; DOI: https://doi.org/10.1124/mol.109.056002
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  15-oxo-Eicosatetraenoic Acid, a Metabolite of Macrophage 15-Hydroxyprostaglandin Dehydrogenase That Inhibits Endothelial Cell Proliferation

  Cong Wei, Peijuan Zhu, Sumit J. Shah and Ian A. Blair

  Molecular Pharmacology September 2009, 76 (3) 516-525; DOI: https://doi.org/10.1124/mol.109.057489
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  Up-Regulation of AGS3 during Morphine Withdrawal Promotes cAMP Superactivation via Adenylyl Cyclase 5 and 7 in Rat Nucleus Accumbens/Striatal Neurons

  Peidong Fan, Zhan Jiang, Ivan Diamond and Lina Yao

  Molecular Pharmacology September 2009, 76 (3) 526-533; DOI: https://doi.org/10.1124/mol.109.057802
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  A Nondesensitizing Kainate Receptor Point Mutant

  Naushaba Nayeem, Yihong Zhang, Devin K. Schweppe, Dean R. Madden and Tim Green

  Molecular Pharmacology September 2009, 76 (3) 534-542; DOI: https://doi.org/10.1124/mol.109.056598
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  Exploring the Mechanism of Agonist Efficacy: A Relationship between Efficacy and Agonist Dissociation Rate at the Muscarinic M₃ Receptor

  David A. Sykes, Mark R. Dowling and Steven J. Charlton

  Molecular Pharmacology September 2009, 76 (3) 543-551; DOI: https://doi.org/10.1124/mol.108.054452
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  Human 5-HT₇ Receptor-Induced Inactivation of Forskolin-Stimulated Adenylate Cyclase by Risperidone, 9-OH-Risperidone and Other “Inactivating Antagonists”

  Nicole Toohey, Michael T. Klein, Jessica Knight, Carol Smith and Milt Teitler

  Molecular Pharmacology September 2009, 76 (3) 552-559; DOI: https://doi.org/10.1124/mol.109.056283
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  The Na⁺/Ca²⁺ Exchange Inhibitor 2-(2-(4-(4-Nitrobenzyloxy)phenyl)ethyl)isothiourea Methanesulfonate (KB-R7943) Also Blocks Ryanodine Receptors Type 1 (RyR1) and Type 2 (RyR2) Channels

  Genaro Barrientos, Diptiman D. Bose, Wei Feng, Isela Padilla and Isaac N. Pessah

  Molecular Pharmacology September 2009, 76 (3) 560-568; DOI: https://doi.org/10.1124/mol.109.057265
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  Selective Activation of the SK1 Subtype of Human Small-Conductance Ca²⁺-Activated K⁺ Channels by 4-(2-Methoxyphenylcarbamoyloxymethyl)-piperidine-1-carboxylic Acid tert-Butyl Ester (GW542573X) Is Dependent on Serine 293 in the S5 Segment

  Charlotte Hougaard, Marianne L. Jensen, Tim J. Dale, David D. Miller, David J. Davies, Birgitte L. Eriksen, Dorte Strøbæk, Derek J. Trezise and Palle Christophersen

  Molecular Pharmacology September 2009, 76 (3) 569-578; DOI: https://doi.org/10.1124/mol.109.056663
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  Benzene Metabolite Hydroquinone Up-Regulates Chondromodulin-I and Inhibits Tube Formation in Human Bone Marrow Endothelial Cells

  Hongfei Zhou, Jadwiga K. Kepa, David Siegel, Shigenori Miura, Yuji Hiraki and David Ross

  Molecular Pharmacology September 2009, 76 (3) 579-587; DOI: https://doi.org/10.1124/mol.109.057323
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  Docosahexaenoic Acid Inhibits Superoxide Dismutase 1 Gene Transcription in Human Cancer Cells: The Involvement of Peroxisome Proliferator-Activated Receptor α and Hypoxia-Inducible Factor-2α Signaling

  Erin R. Tuller, Charles T. Beavers, Jessica R. Lou, Michael A. Ihnat, Doris M. Benbrook and Wei-Qun Ding

  Molecular Pharmacology September 2009, 76 (3) 588-595; DOI: https://doi.org/10.1124/mol.109.057430
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  Autophagy-Mediated Insulin Receptor Down-Regulation Contributes to Endoplasmic Reticulum Stress-Induced Insulin Resistance

  Lijun Zhou, Jingjing Zhang, Qichen Fang, Meilian Liu, Xianling Liu, Weiping Jia, Lily Q. Dong and Feng Liu

  Molecular Pharmacology September 2009, 76 (3) 596-603; DOI: https://doi.org/10.1124/mol.109.057067
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  The Aldo-Keto Reductase Akr1b7 Gene Is a Common Transcriptional Target of Xenobiotic Receptors Pregnane X Receptor and Constitutive Androstane Receptor

  Ming-Jie Liu, Yuki Takahashi, Taira Wada, Jinhan He, Jie Gao, Yanan Tian, Song Li and Wen Xie

  Molecular Pharmacology September 2009, 76 (3) 604-611; DOI: https://doi.org/10.1124/mol.109.057455
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  Adenovirus-Transduced Human Butyrylcholinesterase in Mouse Blood Functions as a Bioscavenger of Chemical Warfare Nerve Agents

  Nageswararao Chilukuri, Ellen G. Duysen, Kalpana Parikh, Robert diTargiani, Bhupendra P. Doctor, Oksana Lockridge and Ashima Saxena

  Molecular Pharmacology September 2009, 76 (3) 612-617; DOI: https://doi.org/10.1124/mol.109.055665
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  Biochemical and Electrophysiological Characterization of Almorexant, a Dual Orexin 1 Receptor (OX₁)/Orexin 2 Receptor (OX₂) Antagonist: Comparison with Selective OX₁ and OX₂ Antagonists

  Pari Malherbe, Edilio Borroni, Emmanuel Pinard, Joseph G. Wettstein and Frédéric Knoflach

  Molecular Pharmacology September 2009, 76 (3) 618-631; DOI: https://doi.org/10.1124/mol.109.055152
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  Etoposide Induces Protein Kinase Cδ- and Caspase-3-Dependent Apoptosis in Neuroblastoma Cancer Cells

  Travis W. Day, Ching-Huang Wu and Ahmad R. Safa

  Molecular Pharmacology September 2009, 76 (3) 632-640; DOI: https://doi.org/10.1124/mol.109.054999
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  Inverse Effects on Gating and Modulation Caused by a Mutation in the M2-M3 Linker of the GABA_A Receptor γ Subunit

  Sean M. O'Shea, Carrie A. Williams and Andrew Jenkins

  Molecular Pharmacology September 2009, 76 (3) 641-651; DOI: https://doi.org/10.1124/mol.109.055111
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  Selective Inhibition of Acetylcholine-Evoked Responses of α7 Neuronal Nicotinic Acetylcholine Receptors by Novel tris- and tetrakis-Azaaromatic Quaternary Ammonium Antagonists

  Gretchen Y. López-Hernández, Jeffrey S. Thinschmidt, Guangrong Zheng, Zhenfa Zhang, Peter A. Crooks, Linda P. Dwoskin and Roger L. Papke

  Molecular Pharmacology September 2009, 76 (3) 652-666; DOI: https://doi.org/10.1124/mol.109.056176
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  Dual Mechanisms of sHA 14-1 in Inducing Cell Death through Endoplasmic Reticulum and Mitochondria

  David Hermanson, Sadiya N. Addo, Anna A. Bajer, Jonathan S. Marchant, Sonia Goutam Kumar Das, Balasubramanian Srinivasan, Fawaz Al-Mousa, Francesco Michelangeli, David D. Thomas, Tucker W. LeBien and Chengguo Xing

  Molecular Pharmacology September 2009, 76 (3) 667-678; DOI: https://doi.org/10.1124/mol.109.055830