Table of Contents

Articles

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  Human CYP24 Catalyzing the Inactivation of Calcitriol Is Post-Transcriptionally Regulated by miR-125b

  Sayaka Komagata, Miki Nakajima, Shingo Takagi, Takuya Mohri, Takao Taniya and Tsuyoshi Yokoi

  Molecular Pharmacology October 2009, 76 (4) 702-709; DOI: https://doi.org/10.1124/mol.109.056986
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  Parallel Functional Activity Profiling Reveals Valvulopathogens Are Potent 5-Hydroxytryptamine_2B Receptor Agonists: Implications for Drug Safety Assessment

  Xi-Ping Huang, Vincent Setola, Prem N. Yadav, John A. Allen, Sarah C. Rogan, Bonnie J. Hanson, Chetana Revankar, Matt Robers, Chris Doucette and Bryan L. Roth

  Molecular Pharmacology October 2009, 76 (4) 710-722; DOI: https://doi.org/10.1124/mol.109.058057
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  Species-Specific Differences in Translational Regulation of Dihydrofolate Reductase

  Yi-Ching Hsieh, Nancy E. Skacel, Nitu Bansal, Kathleen W. Scotto, Debabrata Banerjee, Joseph R. Bertino and Emine Ercikan Abali

  Molecular Pharmacology October 2009, 76 (4) 723-733; DOI: https://doi.org/10.1124/mol.109.055772
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  Reactive Oxygen Species-Dependent Activation of Bax and Poly(ADP-ribose) Polymerase-1 Is Required for Mitochondrial Cell Death Induced by Triterpenoid Pristimerin in Human Cervical Cancer Cells

  Joo-Yun Byun, Min-Jung Kim, Da-Young Eum, Chang-Hwan Yoon, Woo-Duck Seo, Ki Hun Park, Jin-Won Hyun, Yun-Sil Lee, Jae-Seong Lee, Moon-Young Yoon and Su-Jae Lee

  Molecular Pharmacology October 2009, 76 (4) 734-744; DOI: https://doi.org/10.1124/mol.109.056259
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  Licochalcone A Potently Inhibits Tumor Necrosis Factor α-Induced Nuclear Factor-κB Activation through the Direct Inhibition of IκB Kinase Complex Activation

  Megumi Funakoshi-Tago, Saeko Tanabe, Kenji Tago, Hiroshi Itoh, Tadahiko Mashino, Yoshiko Sonoda and Tadashi Kasahara

  Molecular Pharmacology October 2009, 76 (4) 745-753; DOI: https://doi.org/10.1124/mol.109.057448
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  Photodynamic Effects of Steroid-Conjugated Fluorophores on GABA_A Receptors

  Hong-Jin Shu, Lawrence N. Eisenman, Cunde Wang, Achintya K. Bandyopadhyaya, Kathiresan Krishnan, Amanda Taylor, Ann M. Benz, Brad Manion, Alex S. Evers, Douglas F. Covey, Charles F. Zorumski and Steven Mennerick

  Molecular Pharmacology October 2009, 76 (4) 754-765; DOI: https://doi.org/10.1124/mol.109.057687
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  Signal Transducer and Activator of Transcription 3 Is Required for Abnormal Proliferation and Survival of TSC2-Deficient Cells: Relevance to Pulmonary Lymphangioleiomyomatosis

  Elena A. Goncharova, Dmitry A. Goncharov, Gautam Damera, Omar Tliba, Yassine Amrani, Reynold A. Panettieri and Vera P. Krymskaya

  Molecular Pharmacology October 2009, 76 (4) 766-777; DOI: https://doi.org/10.1124/mol.109.057042
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  Group X Phospholipase A₂ Stimulates the Proliferation of Colon Cancer Cells by Producing Various Lipid Mediators

  Fanny Surrel, Ikram Jemel, Eric Boilard, James G. Bollinger, Christine Payré, Carine M. Mounier, Kati A. Talvinen, Veli J. O. Laine, Timo J. Nevalainen, Michael H. Gelb and Gérard Lambeau

  Molecular Pharmacology October 2009, 76 (4) 778-790; DOI: https://doi.org/10.1124/mol.108.053371
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  Agonist-Biased Signaling via Proteinase Activated Receptor-2: Differential Activation of Calcium and Mitogen-Activated Protein Kinase Pathways

  Rithwik Ramachandran, Koichiro Mihara, Maneesh Mathur, Moulay Driss Rochdi, Michel Bouvier, Kathryn DeFea and Morley D. Hollenberg

  Molecular Pharmacology October 2009, 76 (4) 791-801; DOI: https://doi.org/10.1124/mol.109.055509
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  Growth Hormone Secretagogues and Growth Hormone Releasing Peptides Act As Orthosteric Super-Agonists but Not Allosteric Regulators for Activation of the G Protein Gα_o1 by the Ghrelin Receptor

  Kirstie A. Bennett, Christopher J. Langmead, Alan Wise and Graeme Milligan

  Molecular Pharmacology October 2009, 76 (4) 802-811; DOI: https://doi.org/10.1124/mol.109.056101
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  Cyclin-Dependent Kinase 5 Inhibitors: Inhibition of Dopamine Transporter Activity

  David A. Price, Alexander Sorkin and Nancy R. Zahniser

  Molecular Pharmacology October 2009, 76 (4) 812-823; DOI: https://doi.org/10.1124/mol.109.056978
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  An Allosteric Mechanism for Inhibiting HIV-1 Integrase with a Small Molecule

  Jacques J. Kessl, Jocelyn O. Eidahl, Nikolozi Shkriabai, Zhuojun Zhao, Christopher J. McKee, Sonja Hess, Terrence R. Burke and Mamuka Kvaratskhelia

  Molecular Pharmacology October 2009, 76 (4) 824-832; DOI: https://doi.org/10.1124/mol.109.058883
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  Dual Role of the Second Extracellular Loop of the Cannabinoid Receptor 1: Ligand Binding and Receptor Localization

  Kwang H. Ahn, Alexander C. Bertalovitz, Dale F. Mierke and Debra A. Kendall

  Molecular Pharmacology October 2009, 76 (4) 833-842; DOI: https://doi.org/10.1124/mol.109.057356
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  Mechanistic Comparison of Human High-Affinity Copper Transporter 1-Mediated Transport between Copper Ion and Cisplatin

  Zheng D. Liang, David Stockton, Niramol Savaraj and Macus Tien Kuo

  Molecular Pharmacology October 2009, 76 (4) 843-853; DOI: https://doi.org/10.1124/mol.109.056416
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  Peroxisome Proliferator-Activated Receptor γ Coactivator-1α Enhances Antiproliferative Activity of 5′-Deoxy-5-Fluorouridine in Cancer Cells through Induction of Uridine Phosphorylase

  Xingxing Kong, Heng Fan, Xiaojun Liu, Rui Wang, Jichao Liang, Nishith Gupta, Yong Chen, Fude Fang and Yongsheng Chang

  Molecular Pharmacology October 2009, 76 (4) 854-860; DOI: https://doi.org/10.1124/mol.109.056424
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  Novel Molecular Determinants in the Pore Region of Sodium Channels Regulate Local Anesthetic Binding

  Toshio Yamagishi, Wei Xiong, Andre Kondratiev, Patricio Vélez, Ailsa Méndez-Fitzwilliam, Jeffrey R. Balser, Eduardo Marbán and Gordon F. Tomaselli

  Molecular Pharmacology October 2009, 76 (4) 861-871; DOI: https://doi.org/10.1124/mol.109.055863
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  cAMP-Mediated Stimulation of Tyrosine Hydroxylase mRNA Translation Is Mediated by Polypyrimidine-Rich Sequences within Its 3′-Untranslated Region and Poly(C)-Binding Protein 2

  Lu Xu, Carol R. Sterling and A. William Tank

  Molecular Pharmacology October 2009, 76 (4) 872-883; DOI: https://doi.org/10.1124/mol.109.057596
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  Resveratrol Protects Mitochondria against Oxidative Stress through AMP-Activated Protein Kinase-Mediated Glycogen Synthase Kinase-3β Inhibition Downstream of Poly(ADP-ribose)polymerase-LKB1 Pathway

  Sang Mi Shin, Il Je Cho and Sang Geon Kim

  Molecular Pharmacology October 2009, 76 (4) 884-895; DOI: https://doi.org/10.1124/mol.109.058479
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  Reactive Oxygen Species Decrease cAMP Response Element Binding Protein Expression in Cardiomyocytes via a Protein Kinase D1-Dependent Mechanism That Does Not Require Ser¹³³ Phosphorylation

  Nazira Özgen, Jianfen Guo, Zoya Gertsberg, Peter Danilo, Michael R. Rosen and Susan F. Steinberg

  Molecular Pharmacology October 2009, 76 (4) 896-902; DOI: https://doi.org/10.1124/mol.109.056473
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  Inhibition of Human Two-Pore Domain K⁺ Channel TREK1 by Local Anesthetic Lidocaine: Negative Cooperativity and Half-of-Sites Saturation Kinetics

  Tapan K. Nayak, S. Harinath, S. Nama, K. Somasundaram and S. K. Sikdar

  Molecular Pharmacology October 2009, 76 (4) 903-917; DOI: https://doi.org/10.1124/mol.109.056838
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  A Novel Tumor-Targeted Therapy Using a Claudin-4-Targeting Molecule

  Rie Saeki, Masuo Kondoh, Hideki Kakutani, Shin-ichi Tsunoda, Yasuhiro Mochizuki, Takao Hamakubo, Yasuo Tsutsumi, Yasuhiko Horiguchi and Kiyohito Yagi

  Molecular Pharmacology October 2009, 76 (4) 918-926; DOI: https://doi.org/10.1124/mol.109.058412
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  The Translesion Polymerase Rev3L in the Tolerance of Alkylating Anticancer Drugs

  Wynand Paul Roos, Anastasia Tsaalbi-Shtylik, Roman Tsaryk, Fatma Güvercin, Niels de Wind and Bernd Kaina

  Molecular Pharmacology October 2009, 76 (4) 927-934; DOI: https://doi.org/10.1124/mol.109.058131