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Molecular Pharmacology

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Table of Contents

October 2009; Volume 76,Issue 4

MINIREVIEWS

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    Intermolecular Interactions of Sprouty Proteins and Their Implications in Development and Disease
    Francis Edwin, Kimberly Anderson, Chunyi Ying and Tarun B. Patel
    Molecular Pharmacology October 2009, 76 (4) 679-691; DOI: https://doi.org/10.1124/mol.109.055848
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    Herpesvirus-Encoded G Protein-Coupled Receptors as Modulators of Cellular Function
    David Maussang, Henry F. Vischer, Rob Leurs and Martine J. Smit
    Molecular Pharmacology October 2009, 76 (4) 692-701; DOI: https://doi.org/10.1124/mol.109.057091

Articles

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    Human CYP24 Catalyzing the Inactivation of Calcitriol Is Post-Transcriptionally Regulated by miR-125b
    Sayaka Komagata, Miki Nakajima, Shingo Takagi, Takuya Mohri, Takao Taniya and Tsuyoshi Yokoi
    Molecular Pharmacology October 2009, 76 (4) 702-709; DOI: https://doi.org/10.1124/mol.109.056986
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    Parallel Functional Activity Profiling Reveals Valvulopathogens Are Potent 5-Hydroxytryptamine2B Receptor Agonists: Implications for Drug Safety Assessment
    Xi-Ping Huang, Vincent Setola, Prem N. Yadav, John A. Allen, Sarah C. Rogan, Bonnie J. Hanson, Chetana Revankar, Matt Robers, Chris Doucette and Bryan L. Roth
    Molecular Pharmacology October 2009, 76 (4) 710-722; DOI: https://doi.org/10.1124/mol.109.058057
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    Species-Specific Differences in Translational Regulation of Dihydrofolate Reductase
    Yi-Ching Hsieh, Nancy E. Skacel, Nitu Bansal, Kathleen W. Scotto, Debabrata Banerjee, Joseph R. Bertino and Emine Ercikan Abali
    Molecular Pharmacology October 2009, 76 (4) 723-733; DOI: https://doi.org/10.1124/mol.109.055772
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    Reactive Oxygen Species-Dependent Activation of Bax and Poly(ADP-ribose) Polymerase-1 Is Required for Mitochondrial Cell Death Induced by Triterpenoid Pristimerin in Human Cervical Cancer Cells
    Joo-Yun Byun, Min-Jung Kim, Da-Young Eum, Chang-Hwan Yoon, Woo-Duck Seo, Ki Hun Park, Jin-Won Hyun, Yun-Sil Lee, Jae-Seong Lee, Moon-Young Yoon and Su-Jae Lee
    Molecular Pharmacology October 2009, 76 (4) 734-744; DOI: https://doi.org/10.1124/mol.109.056259
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    Licochalcone A Potently Inhibits Tumor Necrosis Factor α-Induced Nuclear Factor-κB Activation through the Direct Inhibition of IκB Kinase Complex Activation
    Megumi Funakoshi-Tago, Saeko Tanabe, Kenji Tago, Hiroshi Itoh, Tadahiko Mashino, Yoshiko Sonoda and Tadashi Kasahara
    Molecular Pharmacology October 2009, 76 (4) 745-753; DOI: https://doi.org/10.1124/mol.109.057448
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    Photodynamic Effects of Steroid-Conjugated Fluorophores on GABAA Receptors
    Hong-Jin Shu, Lawrence N. Eisenman, Cunde Wang, Achintya K. Bandyopadhyaya, Kathiresan Krishnan, Amanda Taylor, Ann M. Benz, Brad Manion, Alex S. Evers, Douglas F. Covey, Charles F. Zorumski and Steven Mennerick
    Molecular Pharmacology October 2009, 76 (4) 754-765; DOI: https://doi.org/10.1124/mol.109.057687
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    Signal Transducer and Activator of Transcription 3 Is Required for Abnormal Proliferation and Survival of TSC2-Deficient Cells: Relevance to Pulmonary Lymphangioleiomyomatosis
    Elena A. Goncharova, Dmitry A. Goncharov, Gautam Damera, Omar Tliba, Yassine Amrani, Reynold A. Panettieri and Vera P. Krymskaya
    Molecular Pharmacology October 2009, 76 (4) 766-777; DOI: https://doi.org/10.1124/mol.109.057042
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    Group X Phospholipase A2 Stimulates the Proliferation of Colon Cancer Cells by Producing Various Lipid Mediators
    Fanny Surrel, Ikram Jemel, Eric Boilard, James G. Bollinger, Christine Payré, Carine M. Mounier, Kati A. Talvinen, Veli J. O. Laine, Timo J. Nevalainen, Michael H. Gelb and Gérard Lambeau
    Molecular Pharmacology October 2009, 76 (4) 778-790; DOI: https://doi.org/10.1124/mol.108.053371
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    Agonist-Biased Signaling via Proteinase Activated Receptor-2: Differential Activation of Calcium and Mitogen-Activated Protein Kinase Pathways
    Rithwik Ramachandran, Koichiro Mihara, Maneesh Mathur, Moulay Driss Rochdi, Michel Bouvier, Kathryn DeFea and Morley D. Hollenberg
    Molecular Pharmacology October 2009, 76 (4) 791-801; DOI: https://doi.org/10.1124/mol.109.055509
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    Growth Hormone Secretagogues and Growth Hormone Releasing Peptides Act As Orthosteric Super-Agonists but Not Allosteric Regulators for Activation of the G Protein Gαo1 by the Ghrelin Receptor
    Kirstie A. Bennett, Christopher J. Langmead, Alan Wise and Graeme Milligan
    Molecular Pharmacology October 2009, 76 (4) 802-811; DOI: https://doi.org/10.1124/mol.109.056101
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    Cyclin-Dependent Kinase 5 Inhibitors: Inhibition of Dopamine Transporter Activity
    David A. Price, Alexander Sorkin and Nancy R. Zahniser
    Molecular Pharmacology October 2009, 76 (4) 812-823; DOI: https://doi.org/10.1124/mol.109.056978
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    An Allosteric Mechanism for Inhibiting HIV-1 Integrase with a Small Molecule
    Jacques J. Kessl, Jocelyn O. Eidahl, Nikolozi Shkriabai, Zhuojun Zhao, Christopher J. McKee, Sonja Hess, Terrence R. Burke and Mamuka Kvaratskhelia
    Molecular Pharmacology October 2009, 76 (4) 824-832; DOI: https://doi.org/10.1124/mol.109.058883
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    Dual Role of the Second Extracellular Loop of the Cannabinoid Receptor 1: Ligand Binding and Receptor Localization
    Kwang H. Ahn, Alexander C. Bertalovitz, Dale F. Mierke and Debra A. Kendall
    Molecular Pharmacology October 2009, 76 (4) 833-842; DOI: https://doi.org/10.1124/mol.109.057356
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    Mechanistic Comparison of Human High-Affinity Copper Transporter 1-Mediated Transport between Copper Ion and Cisplatin
    Zheng D. Liang, David Stockton, Niramol Savaraj and Macus Tien Kuo
    Molecular Pharmacology October 2009, 76 (4) 843-853; DOI: https://doi.org/10.1124/mol.109.056416
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    Peroxisome Proliferator-Activated Receptor γ Coactivator-1α Enhances Antiproliferative Activity of 5′-Deoxy-5-Fluorouridine in Cancer Cells through Induction of Uridine Phosphorylase
    Xingxing Kong, Heng Fan, Xiaojun Liu, Rui Wang, Jichao Liang, Nishith Gupta, Yong Chen, Fude Fang and Yongsheng Chang
    Molecular Pharmacology October 2009, 76 (4) 854-860; DOI: https://doi.org/10.1124/mol.109.056424
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    Novel Molecular Determinants in the Pore Region of Sodium Channels Regulate Local Anesthetic Binding
    Toshio Yamagishi, Wei Xiong, Andre Kondratiev, Patricio Vélez, Ailsa Méndez-Fitzwilliam, Jeffrey R. Balser, Eduardo Marbán and Gordon F. Tomaselli
    Molecular Pharmacology October 2009, 76 (4) 861-871; DOI: https://doi.org/10.1124/mol.109.055863
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    cAMP-Mediated Stimulation of Tyrosine Hydroxylase mRNA Translation Is Mediated by Polypyrimidine-Rich Sequences within Its 3′-Untranslated Region and Poly(C)-Binding Protein 2
    Lu Xu, Carol R. Sterling and A. William Tank
    Molecular Pharmacology October 2009, 76 (4) 872-883; DOI: https://doi.org/10.1124/mol.109.057596
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    Resveratrol Protects Mitochondria against Oxidative Stress through AMP-Activated Protein Kinase-Mediated Glycogen Synthase Kinase-3β Inhibition Downstream of Poly(ADP-ribose)polymerase-LKB1 Pathway
    Sang Mi Shin, Il Je Cho and Sang Geon Kim
    Molecular Pharmacology October 2009, 76 (4) 884-895; DOI: https://doi.org/10.1124/mol.109.058479
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    Reactive Oxygen Species Decrease cAMP Response Element Binding Protein Expression in Cardiomyocytes via a Protein Kinase D1-Dependent Mechanism That Does Not Require Ser133 Phosphorylation
    Nazira Özgen, Jianfen Guo, Zoya Gertsberg, Peter Danilo, Michael R. Rosen and Susan F. Steinberg
    Molecular Pharmacology October 2009, 76 (4) 896-902; DOI: https://doi.org/10.1124/mol.109.056473
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    Inhibition of Human Two-Pore Domain K+ Channel TREK1 by Local Anesthetic Lidocaine: Negative Cooperativity and Half-of-Sites Saturation Kinetics
    Tapan K. Nayak, S. Harinath, S. Nama, K. Somasundaram and S. K. Sikdar
    Molecular Pharmacology October 2009, 76 (4) 903-917; DOI: https://doi.org/10.1124/mol.109.056838
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    A Novel Tumor-Targeted Therapy Using a Claudin-4-Targeting Molecule
    Rie Saeki, Masuo Kondoh, Hideki Kakutani, Shin-ichi Tsunoda, Yasuhiro Mochizuki, Takao Hamakubo, Yasuo Tsutsumi, Yasuhiko Horiguchi and Kiyohito Yagi
    Molecular Pharmacology October 2009, 76 (4) 918-926; DOI: https://doi.org/10.1124/mol.109.058412
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    The Translesion Polymerase Rev3L in the Tolerance of Alkylating Anticancer Drugs
    Wynand Paul Roos, Anastasia Tsaalbi-Shtylik, Roman Tsaryk, Fatma Güvercin, Niels de Wind and Bernd Kaina
    Molecular Pharmacology October 2009, 76 (4) 927-934; DOI: https://doi.org/10.1124/mol.109.058131
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In this issue

Molecular Pharmacology: 76 (4)
Molecular Pharmacology
Vol. 76, Issue 4
October 2009
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Index by author
  • Back Matter (PDF)
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  • SB-431542 Is a Potent and Specific Inhibitor of Transforming Growth Factor-β Superfamily Type I Activin Receptor-Like Kinase (ALK) Receptors ALK4, ALK5, and ALK7
  • The G-Protein-Coupled Receptors in the Human Genome Form Five Main Families. Phylogenetic Analysis, Paralogon Groups, and Fingerprints
  • Pharmacological Properties of Y-27632, a Specific Inhibitor of Rho-Associated Kinases
  • Pharmacological characterization of five cloned voltage-gated K+ channels, types Kv1.1, 1.2, 1.3, 1.5, and 3.1, stably expressed in mammalian cell lines.
  • The Orphan Human Pregnane X Receptor Mediates the Transcriptional Activation of CYP3A4 by Rifampicin through a Distal Enhancer Module
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