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tert-Butylphenylacetylene Is a Potent Mechanism-Based Inactivator of Cytochrome P450 2B4: Inhibition of Cytochrome P450 Catalysis by Steric Hindrance

Haoming Zhang, Hsia-lien Lin, Vyvyca J. Walker, Djemel Hamdane and Paul F. Hollenberg
Molecular Pharmacology November 2009, 76 (5) 1011-1018; DOI: https://doi.org/10.1124/mol.109.059808

Article Information

vol. 76 no. 5 1011-1018
DOI 
https://doi.org/10.1124/mol.109.059808
PubMed 
19720728
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received July 24, 2009
  • Accepted August 28, 2009
  • Published online October 16, 2009.

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Copyright & Usage 
© 2009 The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Haoming Zhang,
  2. Hsia-lien Lin,
  3. Vyvyca J. Walker,
  4. Djemel Hamdane and
  5. Paul F. Hollenberg
  1. Department of Pharmacology, the University of Michigan, Ann Arbor, Michigan (H.Z., H.L.L., V.J.W., P.F.H.); and Laboratoire d'Enzymologie et Biochimie Structurales Unité Propre de Recherche 3082 Centre National de la Recherche Scientifique, Gif-sur-Yvette, France (D.H.)
  1. Address correspondence to:
    Paul F. Hollenberg, PhD, Department of Pharmacology, The University of Michigan, 1150 West Medical Center Drive, 2301 MSRB III, Ann Arbor, MI 48109-5632. E-mail: phollen{at}umich.edu
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tert-Butylphenylacetylene Is a Potent Mechanism-Based Inactivator of Cytochrome P450 2B4: Inhibition of Cytochrome P450 Catalysis by Steric Hindrance

Haoming Zhang, Hsia-lien Lin, Vyvyca J. Walker, Djemel Hamdane and Paul F. Hollenberg
Molecular Pharmacology November 1, 2009, 76 (5) 1011-1018; DOI: https://doi.org/10.1124/mol.109.059808
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