Table of Contents

Articles

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  Regulation of Serotonin 1B Receptor by Glycogen Synthase Kinase-3

  Ligong Chen, Gregory D. Salinas and Xiaohua Li

  Molecular Pharmacology December 2009, 76 (6) 1150-1161; DOI: https://doi.org/10.1124/mol.109.056994
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  β-Arrestin-2 Interaction and Internalization of the Human P2Y₁ Receptor Are Dependent on C-Terminal Phosphorylation Sites

  Susanne Reiner, Nicole Ziegler, Catherine Leon, Kristina Lorenz, Kathrin von Hayn, Christian Gachet, Martin J. Lohse and Carsten Hoffmann

  Molecular Pharmacology December 2009, 76 (6) 1162-1171; DOI: https://doi.org/10.1124/mol.109.060467
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  Influence of the Stereoisomeric Position of the Reactive Acetate Groups of the Benzo[b]Acronycine derivative S23906-1 on Its DNA Alkylation, Helix-Opening, Cytotoxic, and Antitumor Activities

  Sabine Depauw, Thomas Gaslonde, Stéphane Léonce, Laurence Kraus-Berthier, William Laine, Gaëlle Lenglet, Angèle Chiaroni, Bruno Pfeiffer, Christian Bailly, Sylvie Michel, François Tillequin, Alain Pierré and Marie-Hélène David-Cordonnier

  Molecular Pharmacology December 2009, 76 (6) 1172-1185; DOI: https://doi.org/10.1124/mol.109.057554
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  Urotensin II Induces Rat Cardiomyocyte Hypertrophy via the Transient Oxidization of Src Homology 2-Containing Tyrosine Phosphatase and Transactivation of Epidermal Growth Factor Receptor

  Ju-Chi Liu, Cheng-Hsien Chen, Jin-Jer Chen and Tzu-Hurng Cheng

  Molecular Pharmacology December 2009, 76 (6) 1186-1195; DOI: https://doi.org/10.1124/mol.109.058297
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  Subtype-Specific Differences in Corticotropin-Releasing Factor Receptor Complexes Detected by Fluorescence Spectroscopy

  Laura Milan-Lobo, Ingrid Gsandtner, Erwin Gaubitzer, Dominik Rünzler, Florian Buchmayer, Gottfried Köhler, Antonello Bonci, Michael Freissmuth and Harald H. Sitte

  Molecular Pharmacology December 2009, 76 (6) 1196-1210; DOI: https://doi.org/10.1124/mol.109.059139
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  Position 5.46 of the Serotonin 5-HT_2A Receptor Contributes to a Species-Dependent Variation for the 5-HT_2C Agonist (R)-9-Ethyl-1,3,4,10b-tetrahydro-7-trifluoromethylpyrazino[2,1-a]isoindol-6(2H)-one: Impact on Selectivity and Toxicological Evaluation

  Keith J. Miller, Ginger Y. Wu, Jeffrey G. Varnes, Paul Levesque, Julia Li, Danshi Li, Jeffrey A. Robl, Karen A. Rossi and Dean A. Wacker

  Molecular Pharmacology December 2009, 76 (6) 1211-1219; DOI: https://doi.org/10.1124/mol.109.059204
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  Monoacylglycerol Lipase Limits the Duration of Endocannabinoid-Mediated Depolarization-Induced Suppression of Excitation in Autaptic Hippocampal Neurons

  Alex Straiker, Sherry Shu-Jung Hu, Jonathan Z. Long, Andy Arnold, Jim Wager-Miller, Benjamin F. Cravatt and Ken Mackie

  Molecular Pharmacology December 2009, 76 (6) 1220-1227; DOI: https://doi.org/10.1124/mol.109.059030
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  Activation of Retinoic Acid Receptors by Dihydroretinoids

  Alexander R. Moise, Susana Alvarez, Marta Domínguez, Rosana Alvarez, Marcin Golczak, Glenn P. Lobo, Johannes von Lintig, Angel R. de Lera and Krzysztof Palczewski

  Molecular Pharmacology December 2009, 76 (6) 1228-1237; DOI: https://doi.org/10.1124/mol.109.060038
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  An Anticancer Effect of Curcumin Mediated by Down-Regulating Phosphatase of Regenerating Liver-3 Expression on Highly Metastatic Melanoma Cells

  Lu Wang, Yan Shen, Ran Song, Yang Sun, Jianliang Xu and Qiang Xu

  Molecular Pharmacology December 2009, 76 (6) 1238-1245; DOI: https://doi.org/10.1124/mol.109.059105
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  Identification of Survival Genes in Human Glioblastoma Cells by Small Interfering RNA Screening

  Nikhil G. Thaker, Fang Zhang, Peter R. McDonald, Tong Ying Shun, Michael D. Lewen, Ian F. Pollack and John S. Lazo

  Molecular Pharmacology December 2009, 76 (6) 1246-1255; DOI: https://doi.org/10.1124/mol.109.058024
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  N Terminus of Type 5 Adenylyl Cyclase Scaffolds G_s Heterotrimer

  Rachna Sadana, Nathan Dascal and Carmen W. Dessauer

  Molecular Pharmacology December 2009, 76 (6) 1256-1264; DOI: https://doi.org/10.1124/mol.109.058370
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  NRF2 Cysteine Residues Are Critical for Oxidant/Electrophile-Sensing, Kelch-Like ECH-Associated Protein-1-Dependent Ubiquitination-Proteasomal Degradation, and Transcription Activation

  Xiaoqing He and Qiang Ma

  Molecular Pharmacology December 2009, 76 (6) 1265-1278; DOI: https://doi.org/10.1124/mol.109.058453
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  Receptor-Mediated Suppression of Potassium Currents Requires Colocalization within Lipid Rafts

  Susan Oldfield, Jane Hancock, Angharad Mason, Sally A. Hobson, David Wynick, Eamonn Kelly, Andrew D. Randall and Neil V. Marrion

  Molecular Pharmacology December 2009, 76 (6) 1279-1289; DOI: https://doi.org/10.1124/mol.109.058008
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  N6-Substituted cAMP Analogs Inhibit bTREK-1 K⁺ Channels and Stimulate Cortisol Secretion by a Protein Kinase A-Independent Mechanism

  Haiyan Liu, Judith A. Enyeart and John J. Enyeart

  Molecular Pharmacology December 2009, 76 (6) 1290-1301; DOI: https://doi.org/10.1124/mol.109.057075
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  Effects of Positive Allosteric Modulators on Single-Cell Oscillatory Ca²⁺ Signaling Initiated by the Type 5 Metabotropic Glutamate Receptor

  Sophie J. Bradley, Jeannette M. Watson and R. A. John Challiss

  Molecular Pharmacology December 2009, 76 (6) 1302-1313; DOI: https://doi.org/10.1124/mol.109.059170
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  KU135, a Novel Novobiocin-Derived C-Terminal Inhibitor of the 90-kDa Heat Shock Protein, Exerts Potent Antiproliferative Effects in Human Leukemic Cells

  Shary N. Shelton, Mary E. Shawgo, Shawna B. Matthews, Yuanming Lu, Alison C. Donnelly, Kristen Szabla, Mehmet Tanol, George A. Vielhauer, Roger A. Rajewski, Robert L. Matts, Brian S. J. Blagg and John D. Robertson

  Molecular Pharmacology December 2009, 76 (6) 1314-1322; DOI: https://doi.org/10.1124/mol.109.058545
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  P2X7 Receptor Activates Multiple Selective Dye-Permeation Pathways in RAW 264.7 and Human Embryonic Kidney 293 Cells

  Serife Cankurtaran-Sayar, Kemal Sayar and Mehmet Ugur

  Molecular Pharmacology December 2009, 76 (6) 1323-1332; DOI: https://doi.org/10.1124/mol.109.059923
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  Peroxisome Proliferator-Activated Receptor γ Antagonists Decrease Na⁺ Transport via the Epithelial Na⁺ Channel

  Tengis S. Pavlov, Vladislav Levchenko, Alexey V. Karpushev, Alain Vandewalle and Alexander Staruschenko

  Molecular Pharmacology December 2009, 76 (6) 1333-1340; DOI: https://doi.org/10.1124/mol.109.056911
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  Quantification of G_i-Mediated Inhibition of Adenylyl Cyclase Activity Reveals That UDP Is a Potent Agonist of the Human P2Y₁₄ Receptor

  Rhonda L. Carter, Ingrid P. Fricks, Matthew O. Barrett, Lauren E. Burianek, Yixing Zhou, Hyojin Ko, Arijit Das, Kenneth A. Jacobson, Eduardo R. Lazarowski and T. Kendall Harden

  Molecular Pharmacology December 2009, 76 (6) 1341-1348; DOI: https://doi.org/10.1124/mol.109.058578
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  Phosphatidylinositol (4,5)-Bisphosphate Regulation of N-Methyl-d-aspartate Receptor Channels in Cortical Neurons

  Madhuchhanda Mandal and Zhen Yan

  Molecular Pharmacology December 2009, 76 (6) 1349-1359; DOI: https://doi.org/10.1124/mol.109.058701
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  The Basic Helix-Loop-Helix Proteins Differentiated Embryo Chondrocyte (DEC) 1 and DEC2 Function as Corepressors of Retinoid X Receptors

  Yoshitake Cho, Mitsuhide Noshiro, Mihwa Choi, Kentaro Morita, Takeshi Kawamoto, Katsumi Fujimoto, Yukio Kato and Makoto Makishima

  Molecular Pharmacology December 2009, 76 (6) 1360-1369; DOI: https://doi.org/10.1124/mol.109.057000