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Research ArticleArticle

Hepatic Clearance of Reactive Glucuronide Metabolites of Diclofenac in the Mouse Is Dependent on Multiple ATP-Binding Cassette Efflux Transporters

Jurjen S. Lagas, Rolf W. Sparidans, Els Wagenaar, Jos H. Beijnen and Alfred H. Schinkel
Molecular Pharmacology April 2010, 77 (4) 687-694; DOI: https://doi.org/10.1124/mol.109.062364

Article Information

vol. 77 no. 4 687-694
DOI 
https://doi.org/10.1124/mol.109.062364
PubMed 
20086033
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received November 12, 2009
  • Accepted January 19, 2010
  • Published online March 18, 2010.

Article Versions

Copyright & Usage 
Copyright © 2010 The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Jurjen S. Lagas,
  2. Rolf W. Sparidans,
  3. Els Wagenaar,
  4. Jos H. Beijnen and
  5. Alfred H. Schinkel
  1. Division of Molecular Biology, the Netherlands Cancer Institute, Amsterdam, the Netherlands (J.S.L., E.W., A.H.S.); Department of Pharmaceutical Sciences, Utrecht University, Utrecht, the Netherlands (R.W.S., J.H.B.); and Department of Pharmacy and Pharmacology, Slotervaart Hospital, Amsterdam, the Netherlands (J.S.L., J.H.B.)
  1. Address correspondence to:
    Dr. Alfred H. Schinkel, Division Molecular Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, the Netherlands. E-mail: a.schinkel{at}nki.nl
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Research ArticleArticle

Hepatic Clearance of Reactive Glucuronide Metabolites of Diclofenac in the Mouse Is Dependent on Multiple ATP-Binding Cassette Efflux Transporters

Jurjen S. Lagas, Rolf W. Sparidans, Els Wagenaar, Jos H. Beijnen and Alfred H. Schinkel
Molecular Pharmacology April 1, 2010, 77 (4) 687-694; DOI: https://doi.org/10.1124/mol.109.062364
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