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Research ArticleArticle

Orthosteric and Allosteric Modes of Interaction of Novel Selective Agonists of the M1 Muscarinic Acetylcholine Receptor

Vimesh A. Avlani, Christopher J. Langmead, Elizabeth Guida, Martyn D. Wood, Ben G. Tehan, Hugh J. Herdon, Jeannette M. Watson, Patrick M. Sexton and Arthur Christopoulos
Molecular Pharmacology July 2010, 78 (1) 94-104; DOI: https://doi.org/10.1124/mol.110.064345

Article Information

vol. 78 no. 1 94-104
DOI 
https://doi.org/10.1124/mol.110.064345
PubMed 
20413650
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received February 23, 2010
  • Accepted April 21, 2010
  • Published online June 18, 2010.

Article Versions

Copyright & Usage 
Copyright © 2010 The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Vimesh A. Avlani1,
  2. Christopher J. Langmead2,
  3. Elizabeth Guida,
  4. Martyn D. Wood3,
  5. Ben G. Tehan2,
  6. Hugh J. Herdon,
  7. Jeannette M. Watson,
  8. Patrick M. Sexton and
  9. Arthur Christopoulos
  1. Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences and Department of Pharmacology, Monash University, Melbourne, Australia (V.A.A., E.G., P.M.S., A.C.) and GlaxoSmithKline, Harlow, Essex, United Kingdom (M.D.W., C.J.L., J.W., B.G.T., H.J.H., J.M.W.)
  1. Address correspondence to:
    Prof. Arthur Christopoulos, Drug Discovery Biology and, Department of Pharmacology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia. E-mail: arthur.christopoulos{at}med.monash.edu.au

  • ↵1 Current affiliation: School of Molecular and Microbial Biosciences, University of Sydney, Australia.

  • ↵2 Current affiliation: Heptares Therapeutics, BioPark, Welwyn Garden City, Herts., United Kingdom.

  • ↵3 Current affiliation: CNS Research, UCB S.A., Brussels, Belgium.

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Research ArticleArticle

Orthosteric and Allosteric Modes of Interaction of Novel Selective Agonists of the M1 Muscarinic Acetylcholine Receptor

Vimesh A. Avlani, Christopher J. Langmead, Elizabeth Guida, Martyn D. Wood, Ben G. Tehan, Hugh J. Herdon, Jeannette M. Watson, Patrick M. Sexton and Arthur Christopoulos
Molecular Pharmacology July 1, 2010, 78 (1) 94-104; DOI: https://doi.org/10.1124/mol.110.064345
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