Table of Contents

Articles

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  Bryostatin 1 Inhibits Phorbol Ester-Induced Apoptosis in Prostate Cancer Cells by Differentially Modulating Protein Kinase C (PKC) δ Translocation and Preventing PKCδ-Mediated Release of Tumor Necrosis Factor-α

  Vivian A. von Burstin, Liqing Xiao and Marcelo G. Kazanietz

  Molecular Pharmacology September 2010, 78 (3) 325-332; DOI: https://doi.org/10.1124/mol.110.064741
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  The Role of the Methionines and Histidines in the Transmembrane Domain of Mammalian Copper Transporter 1 in the Cellular Accumulation of Cisplatin

  Christopher A. Larson, Preston L. Adams, Brian G. Blair, Roohangiz Safaei and Stephen B. Howell

  Molecular Pharmacology September 2010, 78 (3) 333-339; DOI: https://doi.org/10.1124/mol.110.064766
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  Equilibrium between Adenylyl Cyclase and Phosphodiesterase Patterns Adrenergic Agonist Dose-Dependent Spatiotemporal cAMP/Protein Kinase A Activities in Cardiomyocytes

  Vania De Arcangelis, Shubai Liu, Dawen Zhang, Dagoberto Soto and Yang K. Xiang

  Molecular Pharmacology September 2010, 78 (3) 340-349; DOI: https://doi.org/10.1124/mol.110.064444
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  Genome-wide Expression Profiling Revealed Peripheral Effects of Cannabinoid Receptor 1 Inverse Agonists in Improving Insulin Sensitivity and Metabolic Parameters

  Wenqing Zhao, Olivia Fong, Eric S. Muise, John R. Thompson, Drew Weingarth, Su Qian and Tung M. Fong

  Molecular Pharmacology September 2010, 78 (3) 350-359; DOI: https://doi.org/10.1124/mol.110.064980
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  Allosteric Inhibition of the Regulator of G Protein Signaling–Gα Protein–Protein Interaction by CCG-4986

  David L. Roman, Levi L. Blazer, C. Aaron Monroy and Richard R. Neubig

  Molecular Pharmacology September 2010, 78 (3) 360-365; DOI: https://doi.org/10.1124/mol.109.063388
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  Molecular Determinants for Competitive Inhibition of α4β2 Nicotinic Acetylcholine Receptors

  Patricio Iturriaga-Vásquez, Annalisa Carbone, Olimpo García-Beltrán, Phil D. Livingstone, Philip C. Biggin, Bruce K. Cassels, Susan Wonnacott, Gerald Zapata-Torres and Isabel Bermudez

  Molecular Pharmacology September 2010, 78 (3) 366-375; DOI: https://doi.org/10.1124/mol.110.065490
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  Constitutive Androstane Receptor-Mediated Up-Regulation of ATP-Driven Xenobiotic Efflux Transporters at the Blood-Brain Barrier

  Xueqian Wang, Destiny B. Sykes and David S. Miller

  Molecular Pharmacology September 2010, 78 (3) 376-383; DOI: https://doi.org/10.1124/mol.110.063685
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  Inhibition of Histone Deacetylase 3 Produces Mitotic Defects Independent of Alterations in Histone H3 Lysine 9 Acetylation and Methylation

  Robyn Warrener, KeeMing Chia, William D. Warren, Kelly Brooks and Brian Gabrielli

  Molecular Pharmacology September 2010, 78 (3) 384-393; DOI: https://doi.org/10.1124/mol.109.062976
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  Evidence that Interaction between Conserved Residues in Transmembrane Helices 2, 3, and 7 Are Crucial for Human VPAC₁ Receptor Activation

  Anton O. Chugunov, John Simms, David R. Poyner, Yves Dehouck, Marianne Rooman, Dimitri Gilis and Ingrid Langer

  Molecular Pharmacology September 2010, 78 (3) 394-401; DOI: https://doi.org/10.1124/mol.110.063578
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  Novel Cationic Lipids with Enhanced Gene Delivery and Antimicrobial Activity

  David E. Fein, Robert Bucki, Fitzroy Byfield, Katarzyna Leszczynska, Paul A. Janmey and Scott L. Diamond

  Molecular Pharmacology September 2010, 78 (3) 402-410; DOI: https://doi.org/10.1124/mol.110.066670
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  A Chemical Corrector Modifies the Channel Function of F508del-CFTR

  Patrick Kim Chiaw, Leigh Wellhauser, Ling Jun Huan, Mohabir Ramjeesingh and Christine E. Bear

  Molecular Pharmacology September 2010, 78 (3) 411-418; DOI: https://doi.org/10.1124/mol.110.065862
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  Cellular and Pharmacological Selectivity of the Peroxisome Proliferator-Activated Receptor-β/δ Antagonist GSK3787

  Prajakta S. Palkar, Michael G. Borland, Simone Naruhn, Christina H. Ferry, Christina Lee, Ugir H. Sk, Arun K. Sharma, Shantu Amin, Iain A. Murray, Cherie R. Anderson, Gary H. Perdew, Frank J. Gonzalez, Rolf Müller and Jeffrey M. Peters

  Molecular Pharmacology September 2010, 78 (3) 419-430; DOI: https://doi.org/10.1124/mol.110.065508
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  Arg13 of B-Type Natriuretic Peptide Reciprocally Modulates Binding to Guanylyl Cyclase but Not Clearance Receptors

  Deborah M. Dickey, Kathryn A. Barbieri, Christopher M. McGuirk and Lincoln R. Potter

  Molecular Pharmacology September 2010, 78 (3) 431-435; DOI: https://doi.org/10.1124/mol.110.066084
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  The Histone Deacetylase Inhibitor MGCD0103 Has Both Deacetylase and Microtubule Inhibitory Activity

  KeeMing Chia, Heather Beamish, Kaneez Jafferi and Brian Gabrielli

  Molecular Pharmacology September 2010, 78 (3) 436-443; DOI: https://doi.org/10.1124/mol.110.065169
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  Delineating the Mode of Action of Adenosine A₁ Receptor Allosteric Modulators

  Celine Valant, Luigi Aurelio, Vijay B. Urmaliya, Paul White, Peter J. Scammells, Patrick M. Sexton and Arthur Christopoulos

  Molecular Pharmacology September 2010, 78 (3) 444-455; DOI: https://doi.org/10.1124/mol.110.064568
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  Allosteric Ligands of the Glucagon-Like Peptide 1 Receptor (GLP-1R) Differentially Modulate Endogenous and Exogenous Peptide Responses in a Pathway-Selective Manner: Implications for Drug Screening

  Cassandra Koole, Denise Wootten, John Simms, Celine Valant, Rohan Sridhar, Owen L. Woodman, Laurence J. Miller, Roger J. Summers, Arthur Christopoulos and Patrick M. Sexton

  Molecular Pharmacology September 2010, 78 (3) 456-465; DOI: https://doi.org/10.1124/mol.110.065664
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  Resveratrol Protects Dopamine Neurons Against Lipopolysaccharide-Induced Neurotoxicity through Its Anti-Inflammatory Actions

  Feng Zhang, Jing-Shan Shi, Hui Zhou, Belinda Wilson, Jau-Shyong Hong and Hui-Ming Gao

  Molecular Pharmacology September 2010, 78 (3) 466-477; DOI: https://doi.org/10.1124/mol.110.064535
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  Protein Kinase C-η and Phospholipase D2 Pathway Regulates Foam Cell Formation via Regulator of G Protein Signaling 2

  Hyung-Kyoung Lee, Seungeun Yeo, Jin-Sik Kim, Jin-Gu Lee, Yoe-Sik Bae, Chuhee Lee and Suk-Hwan Baek

  Molecular Pharmacology September 2010, 78 (3) 478-485; DOI: https://doi.org/10.1124/mol.110.064394
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  Antipsychotic Drugs Regulate Hedgehog Signaling by Modulation of 7-Dehydrocholesterol Reductase Levels

  Matthias Lauth, Verena Rohnalter, Åsa Bergström, Mahsa Kooshesh, Per Svenningsson and Rune Toftgård

  Molecular Pharmacology September 2010, 78 (3) 486-496; DOI: https://doi.org/10.1124/mol.110.066431
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  Efficient Hypoxic Activation of the Anticancer Agent AQ4N by CYP2S1 and CYP2W1

  Clinton R. Nishida, Melody Lee and Paul R. Ortiz de Montellano

  Molecular Pharmacology September 2010, 78 (3) 497-502; DOI: https://doi.org/10.1124/mol.110.065045
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  Regulation of Mouse Brain-Selective Sulfotransferase Sult4a1 by cAMP Response Element-Binding Protein and Activating Transcription Factor-2

  Neville J. Butcher, Deanne J. Mitchell, Rachel Burow and Rodney F. Minchin

  Molecular Pharmacology September 2010, 78 (3) 503-510; DOI: https://doi.org/10.1124/mol.110.063404
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  The Effect of Allosteric Modulators on the Kinetics of Agonist-G Protein-Coupled Receptor Interactions in Single Living Cells

  Lauren T. May, Tim J. Self, Stephen J. Briddon and Stephen J. Hill

  Molecular Pharmacology September 2010, 78 (3) 511-523; DOI: https://doi.org/10.1124/mol.110.064493
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  Reversible, Allosteric Small-Molecule Inhibitors of Regulator of G Protein Signaling Proteins

  Levi L. Blazer, David L. Roman, Alfred Chung, Martha J. Larsen, Benjamin M. Greedy, Stephen M. Husbands and Richard R. Neubig

  Molecular Pharmacology September 2010, 78 (3) 524-533; DOI: https://doi.org/10.1124/mol.110.065128