Table of Contents

Articles

• You have access

  Strontium Ranelate Decreases Receptor Activator of Nuclear Factor-κB Ligand-Induced Osteoclastic Differentiation In Vitro: Involvement of the Calcium-Sensing Receptor

  Axelle Caudrillier, Anne-Sophie Hurtel-Lemaire, Alice Wattel, Fabienne Cournarie, Corinne Godin, Laurent Petit, Jean-Pierre Petit, Ernest Terwilliger, Said Kamel, Edward Meigs Brown, Romuald Mentaverri and Michel Brazier

  Molecular Pharmacology October 2010, 78 (4) 569-576; DOI: https://doi.org/10.1124/mol.109.063347
• You have access

  Targeting the Proton-Coupled Folate Transporter for Selective Delivery of 6-Substituted Pyrrolo[2,3-d]Pyrimidine Antifolate Inhibitors of De Novo Purine Biosynthesis in the Chemotherapy of Solid Tumors

  Sita Kugel Desmoulin, Yiqiang Wang, Jianmei Wu, Mark Stout, Zhanjun Hou, Andreas Fulterer, Min-Hwang Chang, Michael F. Romero, Christina Cherian, Aleem Gangjee and Larry H. Matherly

  Molecular Pharmacology October 2010, 78 (4) 577-587; DOI: https://doi.org/10.1124/mol.110.065896
• You have access

  Potassium Channel Block by a Tripartite Complex of Two Cationophilic Ligands and a Potassium Ion

  Pavel I. Zimin, Bojan Garic, Silke B. Bodendiek, Cédrick Mahieux, Heike Wulff and Boris S. Zhorov

  Molecular Pharmacology October 2010, 78 (4) 588-599; DOI: https://doi.org/10.1124/mol.110.064014
• You have access

  Phenylalanine-544 Plays a Key Role in Substrate and Inhibitor Binding by Providing a Hydrophobic Packing Point at the Active Site of Insulin-Regulated Aminopeptidase

  Anthony L. Albiston, Vi Pham, Siying Ye, Leelee Ng, Rebecca A. Lew, Philip E. Thompson, Jessica K. Holien, Craig J. Morton, Michael W. Parker and Siew Yeen Chai

  Molecular Pharmacology October 2010, 78 (4) 600-607; DOI: https://doi.org/10.1124/mol.110.065458
• You have access

  Role of Epigenetic Mechanisms in Differential Regulation of the Dioxin-Inducible Human CYP1A1 and CYP1B1 Genes

  Sudheer R. Beedanagari, Robert T. Taylor, Peter Bui, Feng Wang, Derek W. Nickerson and Oliver Hankinson

  Molecular Pharmacology October 2010, 78 (4) 608-616; DOI: https://doi.org/10.1124/mol.110.064899
• You have access

  Functional Characterization of the Semisynthetic Bile Acid Derivative INT-767, a Dual Farnesoid X Receptor and TGR5 Agonist

  Giovanni Rizzo, Daniela Passeri, Francesca De Franco, Gianmario Ciaccioli, Loredana Donadio, Giorgia Rizzo, Stefano Orlandi, Bahman Sadeghpour, Xiaoxin X. Wang, Tao Jiang, Moshe Levi, Mark Pruzanski and Luciano Adorini

  Molecular Pharmacology October 2010, 78 (4) 617-630; DOI: https://doi.org/10.1124/mol.110.064501
• You have access

  Molecular Model of Anticonvulsant Drug Binding to the Voltage-Gated Sodium Channel Inner Pore

  Gregory M. Lipkind and Harry A. Fozzard

  Molecular Pharmacology October 2010, 78 (4) 631-638; DOI: https://doi.org/10.1124/mol.110.064683
• You have access

  Ligand-Supported Purification of the Urotensin-II Receptor

  Ann T. Du, Döne Onan, Diem T. Dinh, Michael J. Lew, James Ziogas, Marie-Isabel Aguilar, Leonard K. Pattenden and Walter G. Thomas

  Molecular Pharmacology October 2010, 78 (4) 639-647; DOI: https://doi.org/10.1124/mol.110.065151
• You have access

  The M1 Muscarinic Receptor Allosteric Agonists AC-42 and 1-[1′-(2-Methylbenzyl)-1,4′-bipiperidin-4-yl]-1,3-dihydro-2H-benzimidazol-2-one Bind to a Unique Site Distinct from the Acetylcholine Orthosteric Site

  Marlene A. Jacobson, Constantine Kreatsoulas, Danette M. Pascarella, Julie A. O'Brien and Cyrille Sur

  Molecular Pharmacology October 2010, 78 (4) 648-657; DOI: https://doi.org/10.1124/mol.110.065771
• You have access

  Virtual Screening-Based Discovery and Mechanistic Characterization of the Acylthiourea MRT-10 Family as Smoothened Antagonists

  Fabrizio Manetti, Helene Faure, Hermine Roudaut, Tatiana Gorojankina, Elisabeth Traiffort, Angele Schoenfelder, Andre Mann, Antonio Solinas, Maurizio Taddei and Martial Ruat

  Molecular Pharmacology October 2010, 78 (4) 658-665; DOI: https://doi.org/10.1124/mol.110.065102
• You have access

  A Functional Cross-Talk between Liver X Receptor-α and Constitutive Androstane Receptor Links Lipogenesis and Xenobiotic Responses

  Yonggong Zhai, Tara Wada, Bin Zhang, Shaheen Khadem, Songrong Ren, Ramalinga Kuruba, Song Li and Wen Xie

  Molecular Pharmacology October 2010, 78 (4) 666-674; DOI: https://doi.org/10.1124/mol.110.064618
• You have access

  Membrane Transport and Intracellular Sequestration of Novel Thiosemicarbazone Chelators for the Treatment of Cancer

  Angelica M. Merlot, Namfon Pantarat, David B. Lovejoy, Danuta S. Kalinowski and Des R. Richardson

  Molecular Pharmacology October 2010, 78 (4) 675-684; DOI: https://doi.org/10.1124/mol.110.066126
• You have access

  Elimination of a Hydroxyl Group in FTY720 Dramatically Improves the Phosphorylation Rate

  Eve Jary, Thomas Bee, Scott R. Walker, Sung-Kee Chung, Kyung-Chang Seo, Jonathan C. Morris and Anthony S. Don

  Molecular Pharmacology October 2010, 78 (4) 685-692; DOI: https://doi.org/10.1124/mol.110.064873
• You have access

  Mechanism-Based Inactivation of Cytochrome P450 3A4 by Lapatinib

  Woon Chien Teng, Jing Wen Oh, Lee Sun New, Michelle D. Wahlin, Sidney D. Nelson, Han Kiat Ho and Eric Chun Yong Chan

  Molecular Pharmacology October 2010, 78 (4) 693-703; DOI: https://doi.org/10.1124/mol.110.065839
• You have access

  Synergistically Enhanced CYP2B6 Inducibility between a Polymorphic Mutation in CYP2B6 Promoter and Pregnane X Receptor Activation

  Haishan Li, Stephen S. Ferguson and Hongbing Wang

  Molecular Pharmacology October 2010, 78 (4) 704-713; DOI: https://doi.org/10.1124/mol.110.065185
• You have access

  A Novel Polymorphism in a Forkhead Box A1 (FOXA1) Binding Site of the Human UDP Glucuronosyltransferase 2B17 Gene Modulates Promoter Activity and Is Associated with Altered Levels of Circulating Androstane-3α,17β-diol Glucuronide

  Dong Gui Hu, Dione Gardner-Stephen, Gianluca Severi, Philip A. Gregory, Joanna Treloar, Graham G. Giles, Dallas R. English, John L. Hopper, Wayne D. Tilley and Peter I. Mackenzie

  Molecular Pharmacology October 2010, 78 (4) 714-722; DOI: https://doi.org/10.1124/mol.110.065953
• You have access

  Cyclopentenone Prostaglandins with Dienone Structure Promote Cross-Linking of the Chemoresistance-Inducing Enzyme Glutathione Transferase P1-1

  Francisco J. Sánchez-Gómez, Beatriz Díez-Dacal, María A. Pajares, Oscar Llorca and Dolores Pérez-Sala

  Molecular Pharmacology October 2010, 78 (4) 723-733; DOI: https://doi.org/10.1124/mol.110.065391
• You have access

  Blockade by Nanomolar Resveratrol of Quantal Catecholamine Release in Chromaffin Cells

  José Carlos Fernández-Morales, Matilde Yáñez, Francisco Orallo, Lorena Cortés, José Carlos González, Jesús Miguel Hernández-Guijo, Antonio G. García and Antonio M. G. de Diego

  Molecular Pharmacology October 2010, 78 (4) 734-744; DOI: https://doi.org/10.1124/mol.110.066423
• You have access

  Mutagenesis of Nucleophilic Residues near the Orthosteric Binding Pocket of M₁ and M₂ Muscarinic receptors: Effect on the Binding of Nitrogen Mustard Analogs of Acetylcholine and McN-A-343

  Hinako Suga, Gregory W. Sawyer and Frederick J. Ehlert

  Molecular Pharmacology October 2010, 78 (4) 745-755; DOI: https://doi.org/10.1124/mol.110.065367
• You have access

  μ-Opioid Receptors: Correlation of Agonist Efficacy for Signalling with Ability to Activate Internalization

  Jamie McPherson, Guadalupe Rivero, Myma Baptist, Javier Llorente, Suleiman Al-Sabah, Cornelius Krasel, William L. Dewey, Chris P. Bailey, Elizabeth M. Rosethorne, Steven J. Charlton, Graeme Henderson and Eamonn Kelly

  Molecular Pharmacology October 2010, 78 (4) 756-766; DOI: https://doi.org/10.1124/mol.110.066613
• You have access

  An N-Terminal Polybasic Motif of Gα_q Is Required for Signaling and Influences Membrane Nanodomain Distribution

  Marykate Crouthamel, Daniel Abankwa, Li Zhang, Cherisse DiLizio, David R. Manning, John F. Hancock and Philip B. Wedegaertner

  Molecular Pharmacology October 2010, 78 (4) 767-777; DOI: https://doi.org/10.1124/mol.110.066340
• You have access

  Negative Regulatory Effects of Mnk Kinases in the Generation of Chemotherapy-Induced Antileukemic Responses

  Jessica K. Altman, Heather Glaser, Antonella Sassano, Sonali Joshi, Takeshi Ueda, Rie Watanabe-Fukunaga, Rikiro Fukunaga, Martin S. Tallman and Leonidas C. Platanias

  Molecular Pharmacology October 2010, 78 (4) 778-784; DOI: https://doi.org/10.1124/mol.110.064642
• You have access

  Exploring the Binding Site Crevice of a Family B G Protein-Coupled Receptor, the Type 1 Corticotropin Releasing Factor Receptor

  Kostas Gkountelias, Maria Papadokostaki, Jonathan A. Javitch and George Liapakis

  Molecular Pharmacology October 2010, 78 (4) 785-793; DOI: https://doi.org/10.1124/mol.110.065474