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Molecular Pharmacology

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Table of Contents

October 01, 2010; Volume 78,Issue 4

MINIREVIEWS

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    Control of Assembly and Function of Glutamate Receptors by the Amino-Terminal Domain
    Kasper B. Hansen, Hiro Furukawa and Stephen F. Traynelis
    Molecular Pharmacology October 2010, 78 (4) 535-549; DOI: https://doi.org/10.1124/mol.110.067157
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    Thinking Outside of the “RGS Box”: New Approaches to Therapeutic Targeting of Regulators of G Protein Signaling
    Benita Sjögren and Richard R. Neubig
    Molecular Pharmacology October 2010, 78 (4) 550-557; DOI: https://doi.org/10.1124/mol.110.065219

Perspective

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    Mind Your Salts: When the Inactive Constituent Isn't
    Richard R. Neubig
    Molecular Pharmacology October 2010, 78 (4) 558-559; DOI: https://doi.org/10.1124/mol.110.067645

Accelerated Communication

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    Targeting of the Orphan Receptor GPR35 by Pamoic Acid: A Potent Activator of Extracellular Signal-Regulated Kinase and β-Arrestin2 with Antinociceptive Activity
    Pingwei Zhao, Haleli Sharir, Ankur Kapur, Alan Cowan, Ellen B. Geller, Martin W. Adler, Herbert H. Seltzman, Patricia H. Reggio, Susanne Heynen-Genel, Michelle Sauer, Thomas D.Y. Chung, Yushi Bai, Wei Chen, Marc G. Caron, Larry S. Barak and Mary E. Abood
    Molecular Pharmacology October 2010, 78 (4) 560-568; DOI: https://doi.org/10.1124/mol.110.066746

Articles

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    Strontium Ranelate Decreases Receptor Activator of Nuclear Factor-κB Ligand-Induced Osteoclastic Differentiation In Vitro: Involvement of the Calcium-Sensing Receptor
    Axelle Caudrillier, Anne-Sophie Hurtel-Lemaire, Alice Wattel, Fabienne Cournarie, Corinne Godin, Laurent Petit, Jean-Pierre Petit, Ernest Terwilliger, Said Kamel, Edward Meigs Brown, Romuald Mentaverri and Michel Brazier
    Molecular Pharmacology October 2010, 78 (4) 569-576; DOI: https://doi.org/10.1124/mol.109.063347
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    Targeting the Proton-Coupled Folate Transporter for Selective Delivery of 6-Substituted Pyrrolo[2,3-d]Pyrimidine Antifolate Inhibitors of De Novo Purine Biosynthesis in the Chemotherapy of Solid Tumors
    Sita Kugel Desmoulin, Yiqiang Wang, Jianmei Wu, Mark Stout, Zhanjun Hou, Andreas Fulterer, Min-Hwang Chang, Michael F. Romero, Christina Cherian, Aleem Gangjee and Larry H. Matherly
    Molecular Pharmacology October 2010, 78 (4) 577-587; DOI: https://doi.org/10.1124/mol.110.065896
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    Potassium Channel Block by a Tripartite Complex of Two Cationophilic Ligands and a Potassium Ion
    Pavel I. Zimin, Bojan Garic, Silke B. Bodendiek, Cédrick Mahieux, Heike Wulff and Boris S. Zhorov
    Molecular Pharmacology October 2010, 78 (4) 588-599; DOI: https://doi.org/10.1124/mol.110.064014
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    Phenylalanine-544 Plays a Key Role in Substrate and Inhibitor Binding by Providing a Hydrophobic Packing Point at the Active Site of Insulin-Regulated Aminopeptidase
    Anthony L. Albiston, Vi Pham, Siying Ye, Leelee Ng, Rebecca A. Lew, Philip E. Thompson, Jessica K. Holien, Craig J. Morton, Michael W. Parker and Siew Yeen Chai
    Molecular Pharmacology October 2010, 78 (4) 600-607; DOI: https://doi.org/10.1124/mol.110.065458
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    Role of Epigenetic Mechanisms in Differential Regulation of the Dioxin-Inducible Human CYP1A1 and CYP1B1 Genes
    Sudheer R. Beedanagari, Robert T. Taylor, Peter Bui, Feng Wang, Derek W. Nickerson and Oliver Hankinson
    Molecular Pharmacology October 2010, 78 (4) 608-616; DOI: https://doi.org/10.1124/mol.110.064899
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    Functional Characterization of the Semisynthetic Bile Acid Derivative INT-767, a Dual Farnesoid X Receptor and TGR5 Agonist
    Giovanni Rizzo, Daniela Passeri, Francesca De Franco, Gianmario Ciaccioli, Loredana Donadio, Giorgia Rizzo, Stefano Orlandi, Bahman Sadeghpour, Xiaoxin X. Wang, Tao Jiang, Moshe Levi, Mark Pruzanski and Luciano Adorini
    Molecular Pharmacology October 2010, 78 (4) 617-630; DOI: https://doi.org/10.1124/mol.110.064501
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    Molecular Model of Anticonvulsant Drug Binding to the Voltage-Gated Sodium Channel Inner Pore
    Gregory M. Lipkind and Harry A. Fozzard
    Molecular Pharmacology October 2010, 78 (4) 631-638; DOI: https://doi.org/10.1124/mol.110.064683
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    Ligand-Supported Purification of the Urotensin-II Receptor
    Ann T. Du, Döne Onan, Diem T. Dinh, Michael J. Lew, James Ziogas, Marie-Isabel Aguilar, Leonard K. Pattenden and Walter G. Thomas
    Molecular Pharmacology October 2010, 78 (4) 639-647; DOI: https://doi.org/10.1124/mol.110.065151
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    The M1 Muscarinic Receptor Allosteric Agonists AC-42 and 1-[1′-(2-Methylbenzyl)-1,4′-bipiperidin-4-yl]-1,3-dihydro-2H-benzimidazol-2-one Bind to a Unique Site Distinct from the Acetylcholine Orthosteric Site
    Marlene A. Jacobson, Constantine Kreatsoulas, Danette M. Pascarella, Julie A. O'Brien and Cyrille Sur
    Molecular Pharmacology October 2010, 78 (4) 648-657; DOI: https://doi.org/10.1124/mol.110.065771
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    Virtual Screening-Based Discovery and Mechanistic Characterization of the Acylthiourea MRT-10 Family as Smoothened Antagonists
    Fabrizio Manetti, Helene Faure, Hermine Roudaut, Tatiana Gorojankina, Elisabeth Traiffort, Angele Schoenfelder, Andre Mann, Antonio Solinas, Maurizio Taddei and Martial Ruat
    Molecular Pharmacology October 2010, 78 (4) 658-665; DOI: https://doi.org/10.1124/mol.110.065102
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    A Functional Cross-Talk between Liver X Receptor-α and Constitutive Androstane Receptor Links Lipogenesis and Xenobiotic Responses
    Yonggong Zhai, Tara Wada, Bin Zhang, Shaheen Khadem, Songrong Ren, Ramalinga Kuruba, Song Li and Wen Xie
    Molecular Pharmacology October 2010, 78 (4) 666-674; DOI: https://doi.org/10.1124/mol.110.064618
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    Membrane Transport and Intracellular Sequestration of Novel Thiosemicarbazone Chelators for the Treatment of Cancer
    Angelica M. Merlot, Namfon Pantarat, David B. Lovejoy, Danuta S. Kalinowski and Des R. Richardson
    Molecular Pharmacology October 2010, 78 (4) 675-684; DOI: https://doi.org/10.1124/mol.110.066126
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    Elimination of a Hydroxyl Group in FTY720 Dramatically Improves the Phosphorylation Rate
    Eve Jary, Thomas Bee, Scott R. Walker, Sung-Kee Chung, Kyung-Chang Seo, Jonathan C. Morris and Anthony S. Don
    Molecular Pharmacology October 2010, 78 (4) 685-692; DOI: https://doi.org/10.1124/mol.110.064873
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    Mechanism-Based Inactivation of Cytochrome P450 3A4 by Lapatinib
    Woon Chien Teng, Jing Wen Oh, Lee Sun New, Michelle D. Wahlin, Sidney D. Nelson, Han Kiat Ho and Eric Chun Yong Chan
    Molecular Pharmacology October 2010, 78 (4) 693-703; DOI: https://doi.org/10.1124/mol.110.065839
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    Synergistically Enhanced CYP2B6 Inducibility between a Polymorphic Mutation in CYP2B6 Promoter and Pregnane X Receptor Activation
    Haishan Li, Stephen S. Ferguson and Hongbing Wang
    Molecular Pharmacology October 2010, 78 (4) 704-713; DOI: https://doi.org/10.1124/mol.110.065185
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    A Novel Polymorphism in a Forkhead Box A1 (FOXA1) Binding Site of the Human UDP Glucuronosyltransferase 2B17 Gene Modulates Promoter Activity and Is Associated with Altered Levels of Circulating Androstane-3α,17β-diol Glucuronide
    Dong Gui Hu, Dione Gardner-Stephen, Gianluca Severi, Philip A. Gregory, Joanna Treloar, Graham G. Giles, Dallas R. English, John L. Hopper, Wayne D. Tilley and Peter I. Mackenzie
    Molecular Pharmacology October 2010, 78 (4) 714-722; DOI: https://doi.org/10.1124/mol.110.065953
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    Cyclopentenone Prostaglandins with Dienone Structure Promote Cross-Linking of the Chemoresistance-Inducing Enzyme Glutathione Transferase P1-1
    Francisco J. Sánchez-Gómez, Beatriz Díez-Dacal, María A. Pajares, Oscar Llorca and Dolores Pérez-Sala
    Molecular Pharmacology October 2010, 78 (4) 723-733; DOI: https://doi.org/10.1124/mol.110.065391
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    Blockade by Nanomolar Resveratrol of Quantal Catecholamine Release in Chromaffin Cells
    José Carlos Fernández-Morales, Matilde Yáñez, Francisco Orallo, Lorena Cortés, José Carlos González, Jesús Miguel Hernández-Guijo, Antonio G. García and Antonio M. G. de Diego
    Molecular Pharmacology October 2010, 78 (4) 734-744; DOI: https://doi.org/10.1124/mol.110.066423
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    Mutagenesis of Nucleophilic Residues near the Orthosteric Binding Pocket of M1 and M2 Muscarinic receptors: Effect on the Binding of Nitrogen Mustard Analogs of Acetylcholine and McN-A-343
    Hinako Suga, Gregory W. Sawyer and Frederick J. Ehlert
    Molecular Pharmacology October 2010, 78 (4) 745-755; DOI: https://doi.org/10.1124/mol.110.065367
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    μ-Opioid Receptors: Correlation of Agonist Efficacy for Signalling with Ability to Activate Internalization
    Jamie McPherson, Guadalupe Rivero, Myma Baptist, Javier Llorente, Suleiman Al-Sabah, Cornelius Krasel, William L. Dewey, Chris P. Bailey, Elizabeth M. Rosethorne, Steven J. Charlton, Graeme Henderson and Eamonn Kelly
    Molecular Pharmacology October 2010, 78 (4) 756-766; DOI: https://doi.org/10.1124/mol.110.066613
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    An N-Terminal Polybasic Motif of Gαq Is Required for Signaling and Influences Membrane Nanodomain Distribution
    Marykate Crouthamel, Daniel Abankwa, Li Zhang, Cherisse DiLizio, David R. Manning, John F. Hancock and Philip B. Wedegaertner
    Molecular Pharmacology October 2010, 78 (4) 767-777; DOI: https://doi.org/10.1124/mol.110.066340
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    Negative Regulatory Effects of Mnk Kinases in the Generation of Chemotherapy-Induced Antileukemic Responses
    Jessica K. Altman, Heather Glaser, Antonella Sassano, Sonali Joshi, Takeshi Ueda, Rie Watanabe-Fukunaga, Rikiro Fukunaga, Martin S. Tallman and Leonidas C. Platanias
    Molecular Pharmacology October 2010, 78 (4) 778-784; DOI: https://doi.org/10.1124/mol.110.064642
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    Exploring the Binding Site Crevice of a Family B G Protein-Coupled Receptor, the Type 1 Corticotropin Releasing Factor Receptor
    Kostas Gkountelias, Maria Papadokostaki, Jonathan A. Javitch and George Liapakis
    Molecular Pharmacology October 2010, 78 (4) 785-793; DOI: https://doi.org/10.1124/mol.110.065474
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In this issue

Molecular Pharmacology: 78 (4)
Molecular Pharmacology
Vol. 78, Issue 4
1 Oct 2010
  • Table of Contents
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  • Back Matter (PDF)
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  • MINIREVIEWS
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  • SB-431542 Is a Potent and Specific Inhibitor of Transforming Growth Factor-β Superfamily Type I Activin Receptor-Like Kinase (ALK) Receptors ALK4, ALK5, and ALK7
  • The G-Protein-Coupled Receptors in the Human Genome Form Five Main Families. Phylogenetic Analysis, Paralogon Groups, and Fingerprints
  • Pharmacological Properties of Y-27632, a Specific Inhibitor of Rho-Associated Kinases
  • Pharmacological characterization of five cloned voltage-gated K+ channels, types Kv1.1, 1.2, 1.3, 1.5, and 3.1, stably expressed in mammalian cell lines.
  • The Orphan Human Pregnane X Receptor Mediates the Transcriptional Activation of CYP3A4 by Rifampicin through a Distal Enhancer Module
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