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Molecular Pharmacology

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Research ArticleArticle

Targeting the Proton-Coupled Folate Transporter for Selective Delivery of 6-Substituted Pyrrolo[2,3-d]Pyrimidine Antifolate Inhibitors of De Novo Purine Biosynthesis in the Chemotherapy of Solid Tumors

Sita Kugel Desmoulin, Yiqiang Wang, Jianmei Wu, Mark Stout, Zhanjun Hou, Andreas Fulterer, Min-Hwang Chang, Michael F. Romero, Christina Cherian, Aleem Gangjee and Larry H. Matherly
Molecular Pharmacology October 2010, 78 (4) 577-587; DOI: https://doi.org/10.1124/mol.110.065896
Sita Kugel Desmoulin
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Yiqiang Wang
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Jianmei Wu
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Mark Stout
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Zhanjun Hou
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Andreas Fulterer
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Min-Hwang Chang
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Michael F. Romero
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Christina Cherian
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Aleem Gangjee
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Article Information

vol. 78 no. 4 577-587
DOI 
https://doi.org/10.1124/mol.110.065896
PubMed 
20601456

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received April 27, 2010
  • Accepted July 2, 2010
  • Published online September 17, 2010.

Article Versions

  • Earlier version (July 2, 2010 - 07:50).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2010 The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Sita Kugel Desmoulin,
  2. Yiqiang Wang,
  3. Jianmei Wu,
  4. Mark Stout,
  5. Zhanjun Hou,
  6. Andreas Fulterer,
  7. Min-Hwang Chang,
  8. Michael F. Romero,
  9. Christina Cherian,
  10. Aleem Gangjee and
  11. Larry H. Matherly
  1. Graduate Program in Cancer Biology (S.K.D., L.H.M.) and Department of Pharmacology (L.H.M.), Wayne State University School of Medicine, Detroit, Michigan; Developmental Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Detroit, Michigan (J.W., Z.H., C.C., L.H.M.); Department of Pediatrics, Children's Hospital of Michigan, Detroit, Michigan (M.S.); Division of Medicinal Chemistry, Graduate School of Pharmaceutical Science, Duquesne University, Pittsburgh, Pennsylvania (Y.W., A.G.); and Physiology & Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, Minnesota (A.F., M.-H.C., M.F.R.)
  1. Address correspondence to:
    Dr. Larry H. Matherly, Developmental Therapeutics Program, Barbara Ann Karmanos Cancer Institute, 110 E. Warren Ave, Detroit, MI 48201. E-mail: matherly{at}kci.wayne.edu
  1. A.G. and L.H.M. contributed equally to this work.

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Molecular Pharmacology: 78 (4)
Molecular Pharmacology
Vol. 78, Issue 4
1 Oct 2010
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Research ArticleArticle

Targeting the Proton-Coupled Folate Transporter for Selective Delivery of 6-Substituted Pyrrolo[2,3-d]Pyrimidine Antifolate Inhibitors of De Novo Purine Biosynthesis in the Chemotherapy of Solid Tumors

Sita Kugel Desmoulin, Yiqiang Wang, Jianmei Wu, Mark Stout, Zhanjun Hou, Andreas Fulterer, Min-Hwang Chang, Michael F. Romero, Christina Cherian, Aleem Gangjee and Larry H. Matherly
Molecular Pharmacology October 1, 2010, 78 (4) 577-587; DOI: https://doi.org/10.1124/mol.110.065896

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Research ArticleArticle

Targeting the Proton-Coupled Folate Transporter for Selective Delivery of 6-Substituted Pyrrolo[2,3-d]Pyrimidine Antifolate Inhibitors of De Novo Purine Biosynthesis in the Chemotherapy of Solid Tumors

Sita Kugel Desmoulin, Yiqiang Wang, Jianmei Wu, Mark Stout, Zhanjun Hou, Andreas Fulterer, Min-Hwang Chang, Michael F. Romero, Christina Cherian, Aleem Gangjee and Larry H. Matherly
Molecular Pharmacology October 1, 2010, 78 (4) 577-587; DOI: https://doi.org/10.1124/mol.110.065896
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