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The M1 Muscarinic Receptor Allosteric Agonists AC-42 and 1-[1′-(2-Methylbenzyl)-1,4′-bipiperidin-4-yl]-1,3-dihydro-2H-benzimidazol-2-one Bind to a Unique Site Distinct from the Acetylcholine Orthosteric Site

Marlene A. Jacobson, Constantine Kreatsoulas, Danette M. Pascarella, Julie A. O'Brien and Cyrille Sur
Molecular Pharmacology October 2010, 78 (4) 648-657; DOI: https://doi.org/10.1124/mol.110.065771

Article Information

vol. 78 no. 4 648-657
DOI 
https://doi.org/10.1124/mol.110.065771
PubMed 
20660086
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received April 22, 2010
  • Accepted July 21, 2010
  • Published online September 17, 2010.

Article Versions

Copyright & Usage 
Copyright © 2010 The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Marlene A. Jacobson,
  2. Constantine Kreatsoulas,
  3. Danette M. Pascarella,
  4. Julie A. O'Brien and
  5. Cyrille Sur
  1. Departments of Schizophrenia Research (M.A.J., D.M.P., J.A.O.), Molecular Systems (C.K.), and Imaging (C.S.), Merck Research Labs, West Point, Pennsylvania
  1. Address correspondence to:
    Dr. Marlene A. Jacobson, Merck Research Labs, Schizophrenia Research, WP26-265, West Point, PA 19486. E-mail: marlene_jacobson{at}merck.com
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Research ArticleArticle

The M1 Muscarinic Receptor Allosteric Agonists AC-42 and 1-[1′-(2-Methylbenzyl)-1,4′-bipiperidin-4-yl]-1,3-dihydro-2H-benzimidazol-2-one Bind to a Unique Site Distinct from the Acetylcholine Orthosteric Site

Marlene A. Jacobson, Constantine Kreatsoulas, Danette M. Pascarella, Julie A. O'Brien and Cyrille Sur
Molecular Pharmacology October 1, 2010, 78 (4) 648-657; DOI: https://doi.org/10.1124/mol.110.065771
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