The High-Affinity Binding Site for Tricyclic Antidepressants Resides in the Outer Vestibule of the Serotonin Transporter

Institute of Pharmacology, Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria (S.Sa., I.S., H.H.S., M.F., S.Su.); and Department of Medicinal Chemistry, University of Vienna, Vienna, Austria (R.W., G.F.E.)

Address correspondence to:
Dr. Michael Freissmuth, Medical University of Vienna, Institute of Pharmacology, Center for Physiology and Pharmacology, Waehringer Strasse 13a, A-1090 Vienna, Austria. E-mail: michael.freissmuth{at}meduniwien.ac.at

View Full Text

Statistics from Altmetric.com

Article usage

Article usage: October 2010 to June 2022

	Abstract	Full	Pdf
Oct 2010	103	0	217
Nov 2010	388	47	153
Dec 2010	297	42	52
Jan 2011	121	36	59
Feb 2011	115	29	37
Mar 2011	128	24	31
Apr 2011	51	24	26
May 2011	66	23	42
Jun 2011	52	10	16
Jul 2011	39	13	17
Aug 2011	49	25	24
Sep 2011	59	27	16
Oct 2011	49	15	15
Nov 2011	50	11	19
Dec 2011	51	45	34
Jan 2012	48	39	31
Feb 2012	41	25	34
Mar 2012	48	18	39
Apr 2012	53	50	44
May 2012	48	43	37
Jun 2012	26	26	36
Jul 2012	40	24	27
Aug 2012	36	33	25
Sep 2012	49	46	49
Oct 2012	47	41	69
Nov 2012	42	36	49
Dec 2012	33	35	33
Jan 2013	39	32	21
Feb 2013	23	27	31
Mar 2013	58	33	36
Apr 2013	41	30	37
May 2013	32	25	22
Jun 2013	25	21	22
Jul 2013	30	31	19
Aug 2013	14	13	18
Sep 2013	25	14	28
Oct 2013	32	8	27
Nov 2013	19	13	31
Dec 2013	16	5	17
Jan 2014	17	16	14
Feb 2014	17	13	22
Mar 2014	21	22	29
Apr 2014	20	19	25
May 2014	20	24	26
Jun 2014	16	23	9
Jul 2014	23	22	18
Aug 2014	3	13	13
Sep 2014	10	11	30
Oct 2014	20	39	15
Nov 2014	27	16	16
Dec 2014	25	25	18
Jan 2015	21	17	17
Feb 2015	20	7	21
Mar 2015	24	21	25
Apr 2015	15	8	16
May 2015	21	21	22
Jun 2015	21	17	18
Jul 2015	23	21	33
Aug 2015	38	14	18
Sep 2015	28	19	10
Oct 2015	12	17	23
Nov 2015	16	17	13
Dec 2015	14	15	28
Jan 2016	19	15	18
Feb 2016	18	21	19
Mar 2016	12	16	41
Apr 2016	19	6	20
May 2016	15	11	21
Jun 2016	16	21	19
Jul 2016	15	19	22
Aug 2016	19	11	5
Sep 2016	11	15	17
Oct 2016	11	129	17
Nov 2016	6	26	12
Dec 2016	3	20	6
Jan 2017	2	16	6
Feb 2017	6	16	8
Mar 2017	2	45	11
Apr 2017	4	20	45
May 2017	1	19	5
Jun 2017	4	12	11
Jul 2017	1	16	8
Aug 2017	4	22	10
Sep 2017	1	16	13
Oct 2017	3	23	20
Nov 2017	3	27	8
Dec 2017	3	39	15
Jan 2018	2	28	13
Feb 2018	3	15	14
Mar 2018	6	27	20
Apr 2018	2	18	13
May 2018	4	39	24
Jun 2018	4	28	32
Jul 2018	1	21	29
Aug 2018	0	19	17
Sep 2018	1	21	16
Oct 2018	6	33	21
Nov 2018	0	31	23
Dec 2018	18	12	10
Jan 2019	26	2	9
Feb 2019	156	10	9
Mar 2019	41	1	4
Apr 2019	39	1	6
May 2019	28	0	4
Jun 2019	18	0	16
Jul 2019	18	3	17
Aug 2019	29	1	11
Sep 2019	22	0	3
Oct 2019	24	5	17
Nov 2019	31	2	8
Dec 2019	19	3	7
Jan 2020	18	3	2
Feb 2020	21	5	2
Mar 2020	11	1	2
Apr 2020	7	0	0
May 2020	8	0	0
Jun 2020	12	0	3
Jul 2020	11	1	2
Aug 2020	12	2	11
Sep 2020	10	1	3
Oct 2020	26	5	3
Nov 2020	10	1	2
Dec 2020	22	2	6
Jan 2021	24	6	8
Feb 2021	33	4	7
Mar 2021	30	7	5
Apr 2021	29	7	6
May 2021	61	3	3
Jun 2021	17	3	5
Jul 2021	23	2	1
Aug 2021	13	3	5
Sep 2021	11	3	3
Oct 2021	11	1	4
Nov 2021	35	4	13
Dec 2021	18	1	4
Jan 2022	52	1	6
Feb 2022	53	1	3
Mar 2022	18	3	6
Apr 2022	36	4	6
May 2022	40	4	11
Jun 2022	23	3	2