Table of Contents

Articles

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  Molecular Determinants of Human ether-à-go-go-Related Gene 1 (hERG1) K⁺ Channel Activation by NS1643

  Morten Grunnet, Jennifer Abbruzzese, Frank B. Sachse and Michael C. Sanguinetti

  Molecular Pharmacology January 2011, 79 (1) 1-9; DOI: https://doi.org/10.1124/mol.110.067728
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  Diclofenac Distinguishes among Homomeric and Heteromeric Potassium Channels Composed of KCNQ4 and KCNQ5 Subunits

  Lioubov I. Brueggemann, Alexander R. Mackie, Jody L. Martin, Leanne L. Cribbs and Kenneth L. Byron

  Molecular Pharmacology January 2011, 79 (1) 10-23; DOI: https://doi.org/10.1124/mol.110.067496
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  Rational Design of a Selective Covalent Modifier of G Protein βγ Subunits

  Axel L. Dessal, Roger Prades, Ernest Giralt and Alan V. Smrcka

  Molecular Pharmacology January 2011, 79 (1) 24-33; DOI: https://doi.org/10.1124/mol.110.068155
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  TAK-242 (Resatorvid), a Small-Molecule Inhibitor of Toll-Like Receptor (TLR) 4 Signaling, Binds Selectively to TLR4 and Interferes with Interactions between TLR4 and Its Adaptor Molecules

  Naoko Matsunaga, Noboru Tsuchimori, Tatsumi Matsumoto and Masayuki Ii

  Molecular Pharmacology January 2011, 79 (1) 34-41; DOI: https://doi.org/10.1124/mol.110.068064
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  Development of a Selective Small-Molecule Inhibitor of Kir1.1, the Renal Outer Medullary Potassium Channel

  Gautam Bhave, Brian A. Chauder, Wen Liu, Eric S. Dawson, Rishin Kadakia, Thuy T. Nguyen, L. Michelle Lewis, Jens Meiler, C. David Weaver, Lisa M. Satlin, Craig W. Lindsley and Jerod S. Denton

  Molecular Pharmacology January 2011, 79 (1) 42-50; DOI: https://doi.org/10.1124/mol.110.066928
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  Aminoglycosides Inhibit KCNQ4 Channels in Cochlear Outer Hair Cells via Depletion of Phosphatidylinositol(4,5)bisphosphate

  Michael G. Leitner, Christian R. Halaszovich and Dominik Oliver

  Molecular Pharmacology January 2011, 79 (1) 51-60; DOI: https://doi.org/10.1124/mol.110.068130
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  Modulation of Chemokines and Allergic Airway Inflammation by Selective Local Sphingosine-1-phosphate Receptor 1 Agonism in Lungs

  David Marsolais, Saiko Yagi, Tomoyuki Kago, Nora Leaf and Hugh Rosen

  Molecular Pharmacology January 2011, 79 (1) 61-68; DOI: https://doi.org/10.1124/mol.110.066811
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  Pharmacological Characterization of MK-7246, a Potent and Selective CRTH2 (Chemoattractant Receptor-Homologous Molecule Expressed on T-Helper Type 2 Cells) Antagonist

  Francois G. Gervais, Nicole Sawyer, Rino Stocco, Martine Hamel, Connie Krawczyk, Susan Sillaots, Danielle Denis, Elizabeth Wong, Zhaoyin Wang, Michel Gallant, William M. Abraham, Deborah Slipetz, Michael A. Crackower and Gary P. O'Neill

  Molecular Pharmacology January 2011, 79 (1) 69-76; DOI: https://doi.org/10.1124/mol.110.068585
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  Gastrin-Releasing Peptide/Neuromedin B Receptor Antagonists PD176252, PD168368, and Related Analogs Are Potent Agonists of Human Formyl-Peptide Receptors

  Igor A. Schepetkin, Liliya N. Kirpotina, Andrei I. Khlebnikov, Mark A. Jutila and Mark T. Quinn

  Molecular Pharmacology January 2011, 79 (1) 77-90; DOI: https://doi.org/10.1124/mol.110.068288
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  Signaling Pathways Leading to Phosphorylation of Akt and GSK-3β by Activation of Cloned Human and Rat Cerebral D₂ and D₃ Receptors

  Clotilde Mannoury la Cour, Marie-Josèphe Salles, Valérie Pasteau and Mark J. Millan

  Molecular Pharmacology January 2011, 79 (1) 91-105; DOI: https://doi.org/10.1124/mol.110.065409
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  Curcumin Dually Inhibits Both Mammalian Target of Rapamycin and Nuclear Factor-κB Pathways through a Crossed Phosphatidylinositol 3-Kinase/Akt/IκB Kinase Complex Signaling Axis in Adenoid Cystic Carcinoma

  Zhi-Jun Sun, Gang Chen, Wei Zhang, Xiang Hu, Yang Liu, Qian Zhou, Ling-Xing Zhu and Yi-Fang Zhao

  Molecular Pharmacology January 2011, 79 (1) 106-118; DOI: https://doi.org/10.1124/mol.110.066910
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  Acetylcholine Receptor (AChR) α5 Subunit Variant Associated with Risk for Nicotine Dependence and Lung Cancer Reduces (α4β2)₂α5 AChR Function

  Alexander Kuryatov, Wade Berrettini and Jon Lindstrom

  Molecular Pharmacology January 2011, 79 (1) 119-125; DOI: https://doi.org/10.1124/mol.110.066357
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  Expression of Functional Human α6β2β3* Acetylcholine Receptors in Xenopus laevis Oocytes Achieved through Subunit Chimeras and Concatamers

  Alexandre Kuryatov and Jon Lindstrom

  Molecular Pharmacology January 2011, 79 (1) 126-140; DOI: https://doi.org/10.1124/mol.110.066159
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  CGP-37157 Inhibits the Sarcoplasmic Reticulum Ca²⁺ ATPase and Activates Ryanodine Receptor Channels in Striated Muscle

  Jake T. Neumann, Paula L. Diaz-Sylvester, Sidney Fleischer and Julio A. Copello

  Molecular Pharmacology January 2011, 79 (1) 141-147; DOI: https://doi.org/10.1124/mol.110.067165
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  Activated Sterol Regulatory Element-Binding Protein-2 Suppresses Hepatocyte Nuclear Factor-4-Mediated Cyp3a11 Expression in Mouse Liver

  Shin-ichi Inoue, Kouichi Yoshinari, Mika Sugawara and Yasushi Yamazoe

  Molecular Pharmacology January 2011, 79 (1) 148-156; DOI: https://doi.org/10.1124/mol.110.068577
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  Copper Transporter 2 Regulates Endocytosis and Controls Tumor Growth and Sensitivity to Cisplatin In Vivo

  Brian G. Blair, Christopher A. Larson, Preston L. Adams, Paolo B. Abada, Catherine E. Pesce, Roohangiz Safaei and Stephen B. Howell

  Molecular Pharmacology January 2011, 79 (1) 157-166; DOI: https://doi.org/10.1124/mol.110.068411
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  α4β2 Nicotinic Receptors Partially Mediate Anti-Inflammatory Effects through Janus Kinase 2-Signal Transducer and Activator of Transcription 3 but Not Calcium or cAMP Signaling

  Vishnu Hosur and Ralph H. Loring

  Molecular Pharmacology January 2011, 79 (1) 167-174; DOI: https://doi.org/10.1124/mol.110.066381
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  Rab GTPases Bind at a Common Site within the Angiotensin II Type I Receptor Carboxyl-Terminal Tail: Evidence that Rab4 Regulates Receptor Phosphorylation, Desensitization, and Resensitization

  Jessica L. Esseltine, Lianne B. Dale and Stephen S. G. Ferguson

  Molecular Pharmacology January 2011, 79 (1) 175-184; DOI: https://doi.org/10.1124/mol.110.068379
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  Iron Chelators of the Di-2-pyridylketone Thiosemicarbazone and 2-Benzoylpyridine Thiosemicarbazone Series Inhibit HIV-1 Transcription: Identification of Novel Cellular Targets—Iron, Cyclin-Dependent Kinase (CDK) 2, and CDK9

  Zufan Debebe, Tatyana Ammosova, Denitra Breuer, David B. Lovejoy, Danuta S. Kalinowski, Pradeep K. Karla, Krishna Kumar, Marina Jerebtsova, Patricio Ray, Fatah Kashanchi, Victor R. Gordeuk, Des R. Richardson and Sergei Nekhai

  Molecular Pharmacology January 2011, 79 (1) 185-196; DOI: https://doi.org/10.1124/mol.110.069062
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  Histone Deacetylase Inhibitors Stimulate Histone H3 Lysine 4 Methylation in Part Via Transcriptional Repression of Histone H3 Lysine 4 Demethylases

  Po-Hsien Huang, Chun-Han Chen, Chih-Chien Chou, Aaron M. Sargeant, Samuel K. Kulp, Che-Ming Teng, John C. Byrd and Ching-Shih Chen

  Molecular Pharmacology January 2011, 79 (1) 197-206; DOI: https://doi.org/10.1124/mol.110.067702