Molecular Pharmacology: 79 (4)

April 01, 2011; Volume 79,Issue 4

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Paradoxical Stimulatory Effects of the “Standard” Histamine H₄-Receptor Antagonist JNJ7777120: the H₄ Receptor Joins the Club of 7 Transmembrane Domain Receptors Exhibiting Functional Selectivity
Roland Seifert, Erich H. Schneider, Stefan Dove, Irena Brunskole, Detlef Neumann, Andrea Strasser and Armin Buschauer

Molecular Pharmacology April 2011, 79 (4) 631-638; DOI: https://doi.org/10.1124/mol.111.071266

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The High-Affinity cAMP-Specific Phosphodiesterase 8B Controls Steroidogenesis in the Mouse Adrenal Gland
Li-Chun Lisa Tsai, Masami Shimizu-Albergine and Joseph A. Beavo

Molecular Pharmacology April 2011, 79 (4) 639-648; DOI: https://doi.org/10.1124/mol.110.069104
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Molecular Determinants of Potent P2X2 Antagonism Identified by Functional Analysis, Mutagenesis, and Homology Docking
Christian Wolf, Christiane Rosefort, Ghada Fallah, Matthias U. Kassack, Alexandra Hamacher, Mandy Bodnar, Haihong Wang, Peter Illes, Achim Kless, Gregor Bahrenberg, Günther Schmalzing and Ralf Hausmann

Molecular Pharmacology April 2011, 79 (4) 649-661; DOI: https://doi.org/10.1124/mol.110.068700
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A State-Dependent Salt-Bridge Interaction Exists across the β/α Intersubunit Interface of the GABA_A Receptor
Kurt T. Laha and David A. Wagner

Molecular Pharmacology April 2011, 79 (4) 662-671; DOI: https://doi.org/10.1124/mol.110.068619
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The Tricyclic Antidepressant Amitriptyline Inhibits d-Cyclin Transactivation and Induces Myeloma Cell Apoptosis by Inhibiting Histone Deacetylases: In Vitro and In Silico Evidence
Xinliang Mao, Tingjun Hou, Biyin Cao, Wenjie Wang, Zhihua Li, Suning Chen, Min Fei, Rose Hurren, Marcela Gronda, Depei Wu, Suzanne Trudel and Aaron D. Schimmer

Molecular Pharmacology April 2011, 79 (4) 672-680; DOI: https://doi.org/10.1124/mol.110.068122
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Why Does the Inner-Helix Mutation A413C Double the Stoichiometry of Kv1.3 Channel Block by Emopamil but Not by Verapamil?
Alexey Rossokhin, Tobias Dreker, Stephan Grissmer and Boris S. Zhorov

Molecular Pharmacology April 2011, 79 (4) 681-691; DOI: https://doi.org/10.1124/mol.110.068031
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Coupling to Polymeric Scaffolds Stabilizes Biofunctional Peptides for Intracellular Applications
Ivo R. Ruttekolk, Alokta Chakrabarti, Martin Richter, Falk Duchardt, Heike Glauner, Wouter P. R. Verdurmen, Jörg Rademann and Roland Brock

Molecular Pharmacology April 2011, 79 (4) 692-700; DOI: https://doi.org/10.1124/mol.110.068296
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Helix 8 of the M₁ Muscarinic Acetylcholine Receptor: Scanning Mutagenesis Delineates a G Protein Recognition Site
Robert G. Kaye, José W. Saldanha, Zhi-Liang Lu and Edward C. Hulme

Molecular Pharmacology April 2011, 79 (4) 701-709; DOI: https://doi.org/10.1124/mol.110.070177
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A Novel Defensive Mechanism against Acetaminophen Toxicity in the Mouse Lateral Nasal Gland: Role of CYP2A5-Mediated Regulation of Testosterone Homeostasis and Salivary Androgen-Binding Protein Expression
Xin Zhou, Yuan Wei, Fang Xie, Christina M. Laukaitis, Robert C. Karn, Kerri Kluetzman, Jun Gu, Qing-Yu Zhang, Dean W. Roberts and Xinxin Ding

Molecular Pharmacology April 2011, 79 (4) 710-723; DOI: https://doi.org/10.1124/mol.110.070045
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Acute Disruption of Bone Marrow Hematopoiesis by Benzo(a)pyrene Is Selectively Reversed by Aryl Hydrocarbon Receptor-Mediated Processes
Alhaji U. N′jai, Michele C. Larsen, Justin R. Bushkofsky, Charles J. Czuprynski and Colin R. Jefcoate

Molecular Pharmacology April 2011, 79 (4) 724-734; DOI: https://doi.org/10.1124/mol.110.070631
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Novel Regulation of Nuclear Factor-YB by miR-485-3p Affects the Expression of DNA Topoisomerase IIα and Drug Responsiveness
Cheng-Fen Chen, Xiaolong He, Ahmet Dirim Arslan, Yin-Yuan Mo, William C. Reinhold, Yves Pommier and William T. Beck

Molecular Pharmacology April 2011, 79 (4) 735-741; DOI: https://doi.org/10.1124/mol.110.069633
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A Cation-π Interaction at a Phenylalanine Residue in the Glycine Receptor Binding Site Is Conserved for Different Agonists
Stephan A. Pless, Ariele P. Hanek, Kerry L. Price, Joseph W. Lynch, Henry A. Lester, Dennis A. Dougherty and Sarah C. R. Lummis

Molecular Pharmacology April 2011, 79 (4) 742-748; DOI: https://doi.org/10.1124/mol.110.069583
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Agonist-Biased Signaling at the Histamine H₄ Receptor: JNJ7777120 Recruits β-Arrestin without Activating G Proteins
Elizabeth M. Rosethorne and Steven J. Charlton

Molecular Pharmacology April 2011, 79 (4) 749-757; DOI: https://doi.org/10.1124/mol.110.068395
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Effects of the Allosteric Antagonist 1-(4-Chlorophenyl)-3-[3-(6-pyrrolidin-1-ylpyridin-2-yl)phenyl]urea (PSNCBAM-1) on CB₁ Receptor Modulation in the Cerebellum
Xiaowei Wang, James G. Horswill, Benjamin J. Whalley and Gary J. Stephens

Molecular Pharmacology April 2011, 79 (4) 758-767; DOI: https://doi.org/10.1124/mol.110.068197
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Protein Kinase C-Mediated Phosphorylation of the μ-Opioid Receptor and Its Effects on Receptor Signaling
Bo Feng, Zhihua Li and Jia Bei Wang

Molecular Pharmacology April 2011, 79 (4) 768-775; DOI: https://doi.org/10.1124/mol.110.069096
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The Penultimate Arginine of the Carboxyl Terminus Determines Slow Desensitization in a P2X Receptor from the Cattle Tick Boophilus microplus
Selvan Bavan, Louise Farmer, Shire K. Singh, Volko A. Straub, Felix D. Guerrero and Steven J. Ennion

Molecular Pharmacology April 2011, 79 (4) 776-785; DOI: https://doi.org/10.1124/mol.110.070037
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Proinflammatory Stimuli Control N-Acylphosphatidylethanolamine-Specific Phospholipase D Expression in Macrophages
Chenggang Zhu, Carlos Solorzano, Saurabh Sahar, Natalia Realini, Ernest Fung, Paolo Sassone-Corsi and Daniele Piomelli

Molecular Pharmacology April 2011, 79 (4) 786-792; DOI: https://doi.org/10.1124/mol.110.070201

Erratum

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Correction to “Antipsychotic Drugs Regulate Hedgehog Signaling by Modulation of 7-Dehydrocholesterol Reductase Levels”
Molecular Pharmacology April 2011, 79 (4) 793; DOI: https://doi.org/10.1124/mol.79.4.793

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