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Research ArticleArticle

Molecular Determinants of Potent P2X2 Antagonism Identified by Functional Analysis, Mutagenesis, and Homology Docking

Christian Wolf, Christiane Rosefort, Ghada Fallah, Matthias U. Kassack, Alexandra Hamacher, Mandy Bodnar, Haihong Wang, Peter Illes, Achim Kless, Gregor Bahrenberg, Günther Schmalzing and Ralf Hausmann
Molecular Pharmacology April 2011, 79 (4) 649-661; DOI: https://doi.org/10.1124/mol.110.068700
Christian Wolf
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Christiane Rosefort
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Ghada Fallah
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Matthias U. Kassack
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Alexandra Hamacher
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Mandy Bodnar
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Haihong Wang
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Peter Illes
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Achim Kless
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Gregor Bahrenberg
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Günther Schmalzing
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Ralf Hausmann
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Article Information

vol. 79 no. 4 649-661
DOI 
https://doi.org/10.1124/mol.110.068700
PubMed 
21191044

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received September 6, 2010
  • Accepted December 29, 2010
  • Published online March 18, 2011.

Article Versions

  • Earlier version (December 29, 2010 - 08:25).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2011 The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Christian Wolf,
  2. Christiane Rosefort,
  3. Ghada Fallah,
  4. Matthias U. Kassack,
  5. Alexandra Hamacher,
  6. Mandy Bodnar,
  7. Haihong Wang,
  8. Peter Illes,
  9. Achim Kless,
  10. Gregor Bahrenberg,
  11. Günther Schmalzing and
  12. Ralf Hausmann
  1. Molecular Pharmacology, RWTH Aachen University, Aachen, Germany (C.W., C.R., G.F., G.S., R.H.); Institute of Pharmaceutical & Medicinal Chemistry, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany (M.U.K., A.H.); Rudolf-Boehm Institute for Pharmacology and Toxicology, University of Leipzig, Leipzig, Germany (M.B., H.W., P.I.); and Grünenthal GmbH, Global Drug Discovery, Departments of Molecular Pharmacology and Discovery Informatics, Aachen, Germany (A.K., G.B.)
  1. Address correspondence to:
    Ralf Hausmann, Department of Molecular Pharmacology, University Hospital of RWTH Aachen University, Wendlingweg 2, D-52074 Aachen, Germany. E-mail: rhausmann{at}ukaachen.de
  1. 1 C.W. and C.R., contributed equally to this work.

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Molecular Pharmacology: 79 (4)
Molecular Pharmacology
Vol. 79, Issue 4
1 Apr 2011
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Research ArticleArticle

Molecular Determinants of Potent P2X2 Antagonism Identified by Functional Analysis, Mutagenesis, and Homology Docking

Christian Wolf, Christiane Rosefort, Ghada Fallah, Matthias U. Kassack, Alexandra Hamacher, Mandy Bodnar, Haihong Wang, Peter Illes, Achim Kless, Gregor Bahrenberg, Günther Schmalzing and Ralf Hausmann
Molecular Pharmacology April 1, 2011, 79 (4) 649-661; DOI: https://doi.org/10.1124/mol.110.068700

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Research ArticleArticle

Molecular Determinants of Potent P2X2 Antagonism Identified by Functional Analysis, Mutagenesis, and Homology Docking

Christian Wolf, Christiane Rosefort, Ghada Fallah, Matthias U. Kassack, Alexandra Hamacher, Mandy Bodnar, Haihong Wang, Peter Illes, Achim Kless, Gregor Bahrenberg, Günther Schmalzing and Ralf Hausmann
Molecular Pharmacology April 1, 2011, 79 (4) 649-661; DOI: https://doi.org/10.1124/mol.110.068700
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