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Molecular Pharmacology

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Research ArticleArticle

The Tricyclic Antidepressant Amitriptyline Inhibits d-Cyclin Transactivation and Induces Myeloma Cell Apoptosis by Inhibiting Histone Deacetylases: In Vitro and In Silico Evidence

Xinliang Mao, Tingjun Hou, Biyin Cao, Wenjie Wang, Zhihua Li, Suning Chen, Min Fei, Rose Hurren, Marcela Gronda, Depei Wu, Suzanne Trudel and Aaron D. Schimmer
Molecular Pharmacology April 2011, 79 (4) 672-680; DOI: https://doi.org/10.1124/mol.110.068122
Xinliang Mao
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Tingjun Hou
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Biyin Cao
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Wenjie Wang
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Zhihua Li
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Suning Chen
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Min Fei
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Rose Hurren
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Marcela Gronda
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Depei Wu
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Suzanne Trudel
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Article Information

vol. 79 no. 4 672-680
DOI 
https://doi.org/10.1124/mol.110.068122
PubMed 
21220410

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received August 12, 2010
  • Accepted January 6, 2011
  • Published online March 18, 2011.

Article Versions

  • Earlier version (January 10, 2011 - 04:58).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2011 The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Xinliang Mao,
  2. Tingjun Hou,
  3. Biyin Cao,
  4. Wenjie Wang,
  5. Zhihua Li,
  6. Suning Chen,
  7. Min Fei,
  8. Rose Hurren,
  9. Marcela Gronda,
  10. Depei Wu,
  11. Suzanne Trudel and
  12. Aaron D. Schimmer
  1. Cyrus Tang Hematology Center, Jiangsu Institute of Hematology, the First Affiliated Hospital (X.M., B.C., W.W., S.C., M.F., D.W.), and Institute of Functional Nano & Soft Materials (FUNSOM) and Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices (T.H.), Soochow University, Suzhou, China; and Princess Margaret Hospital, Ontario Cancer Institute, Toronto, Ontario, Canada (X.M., Z.L., R.H., M.G., S.T., A.D.S.)
  1. Address correspondence to:
    Dr. Xinliang Mao, Laboratory of Targeted Anti-leukemia Drug Discovery, Cyrus Tang Hematology Center, Soochow University, 199 Ren Ai Road, Room 703-507, Suzhou Industrial Park, Suzhou, Jiangsu 215123, China. E-mail: xinliangmao{at}suda.edu.cn
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Molecular Pharmacology: 79 (4)
Molecular Pharmacology
Vol. 79, Issue 4
1 Apr 2011
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Research ArticleArticle

The Tricyclic Antidepressant Amitriptyline Inhibits d-Cyclin Transactivation and Induces Myeloma Cell Apoptosis by Inhibiting Histone Deacetylases: In Vitro and In Silico Evidence

Xinliang Mao, Tingjun Hou, Biyin Cao, Wenjie Wang, Zhihua Li, Suning Chen, Min Fei, Rose Hurren, Marcela Gronda, Depei Wu, Suzanne Trudel and Aaron D. Schimmer
Molecular Pharmacology April 1, 2011, 79 (4) 672-680; DOI: https://doi.org/10.1124/mol.110.068122

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Research ArticleArticle

The Tricyclic Antidepressant Amitriptyline Inhibits d-Cyclin Transactivation and Induces Myeloma Cell Apoptosis by Inhibiting Histone Deacetylases: In Vitro and In Silico Evidence

Xinliang Mao, Tingjun Hou, Biyin Cao, Wenjie Wang, Zhihua Li, Suning Chen, Min Fei, Rose Hurren, Marcela Gronda, Depei Wu, Suzanne Trudel and Aaron D. Schimmer
Molecular Pharmacology April 1, 2011, 79 (4) 672-680; DOI: https://doi.org/10.1124/mol.110.068122
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