Table of Contents

Articles

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  Negative Gating Modulation by (R)-N-(Benzimidazol-2-yl)-1,2,3,4-tetrahydro-1-naphthylamine (NS8593) Depends on Residues in the Inner Pore Vestibule: Pharmacological Evidence of Deep-Pore Gating of K_Ca2 Channels

  David Paul Jenkins, Dorte Strøbæk, Charlotte Hougaard, Marianne L. Jensen, Rene Hummel, Ulrik S. Sørensen, Palle Christophersen and Heike Wulff

  Molecular Pharmacology June 2011, 79 (6) 899-909; DOI: https://doi.org/10.1124/mol.110.069807
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  Pharmacological Characterization of 1-(5-Chloro-6-(trifluoromethoxy)-1H-benzoimidazol-2-yl)-1H-pyrazole-4-carboxylic Acid (JNJ-42041935), a Potent and Selective Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor

  Terrance D. Barrett, Heather L. Palomino, Theresa I. Brondstetter, Kimon C. Kanelakis, Xiaodong Wu, Peter V. Haug, Wen Yan, Andrew Young, Hong Hua, Juliet C. Hart, Da-Thao Tran, Hariharan Venkatesan, Mark D. Rosen, Hillary M. Peltier, Kia Sepassi, Michele C. Rizzolio, Scott D. Bembenek, Tara Mirzadegan, Michael H. Rabinowitz and Nigel P. Shankley

  Molecular Pharmacology June 2011, 79 (6) 910-920; DOI: https://doi.org/10.1124/mol.110.070508
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  The Potent and Novel Thiosemicarbazone Chelators Di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone and 2-Benzoylpyridine-4,4-dimethyl-3-thiosemicarbazone Affect Crucial Thiol Systems Required for Ribonucleotide Reductase Activity

  Yu Yu, Yohan Suryo Rahmanto, Clare L. Hawkins and Des R. Richardson

  Molecular Pharmacology June 2011, 79 (6) 921-931; DOI: https://doi.org/10.1124/mol.111.071324
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  Poly(ADP-ribose) Polymerase-1 Is a Nuclear Epigenetic Regulator of Mitochondrial DNA Repair and Transcription

  Andrea Lapucci, Maria Pittelli, Elena Rapizzi, Roberta Felici, Flavio Moroni and Alberto Chiarugi

  Molecular Pharmacology June 2011, 79 (6) 932-940; DOI: https://doi.org/10.1124/mol.110.070110
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  Phosphatase and Tensin Homolog Deleted on Chromosome 10 (PTEN) Inhibition by 4-Hydroxynonenal Leads to Increased Akt Activation in Hepatocytes

  Colin T. Shearn, Rebecca L. Smathers, Benjamin J. Stewart, Kristofer S. Fritz, James J. Galligan, Numsen Hail and Dennis R. Petersen

  Molecular Pharmacology June 2011, 79 (6) 941-952; DOI: https://doi.org/10.1124/mol.110.069534
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  RNA-Induced Silencing Complex-Bound Small Interfering RNA Is a Determinant of RNA Interference-Mediated Gene Silencing in Mice

  Jie Wei, Jeffrey Jones, Jing Kang, Ananda Card, Michael Krimm, Paula Hancock, Yi Pei, Brandon Ason, Elmer Payson, Natalya Dubinina, Mark Cancilla, Mark Stroh, Julja Burchard, Alan B. Sachs, Jerome H. Hochman, W. Michael Flanagan and Nelly A. Kuklin

  Molecular Pharmacology June 2011, 79 (6) 953-963; DOI: https://doi.org/10.1124/mol.110.070409
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  Cannabidiol and Other Cannabinoids Reduce Microglial Activation In Vitro and In Vivo: Relevance to Alzheimer's Disease

  Ana María Martín-Moreno, David Reigada, Belén G. Ramírez, R. Mechoulam, Nadia Innamorato, Antonio Cuadrado and María L. de Ceballos

  Molecular Pharmacology June 2011, 79 (6) 964-973; DOI: https://doi.org/10.1124/mol.111.071290
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  Glycogen Synthase Kinase-3β Is a Functional Modulator of Serotonin-1B Receptors

  L. Chen, W. Zhou, P. C. Chen, I. Gaisina, S. Yang and X. Li

  Molecular Pharmacology June 2011, 79 (6) 974-986; DOI: https://doi.org/10.1124/mol.111.071092
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  Regulation of Calcium Channels and Exocytosis in Mouse Adrenal Chromaffin Cells by Prostaglandin EP3 Receptors

  Mark L. Jewell, Richard M. Breyer and Kevin P. M. Currie

  Molecular Pharmacology June 2011, 79 (6) 987-996; DOI: https://doi.org/10.1124/mol.110.068569
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  The Bcl-2 Homology Domain 3 (BH3) Mimetic ABT-737 Reveals the Dynamic Regulation of Bad, a Proapoptotic Protein of the Bcl-2 Family, by Bcl-xL

  Zakaria Ezzoukhry, Christophe Louandre, Catherine François, Zuzana Saidak, Corinne Godin, Jean-Claude Mazière and Antoine Galmiche

  Molecular Pharmacology June 2011, 79 (6) 997-1004; DOI: https://doi.org/10.1124/mol.110.070565
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  PMX-53 as a Dual CD88 Antagonist and an Agonist for Mas-Related Gene 2 (MrgX2) in Human Mast Cells

  Hariharan Subramanian, Sakeen W. Kashem, Sarah J. Collington, Hongchang Qu, John D. Lambris and Hydar Ali

  Molecular Pharmacology June 2011, 79 (6) 1005-1013; DOI: https://doi.org/10.1124/mol.111.071472
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  Galangin Suppresses the Proliferation of β-Catenin Response Transcription-Positive Cancer Cells by Promoting Adenomatous Polyposis Coli/Axin/Glycogen Synthase Kinase-3β-Independent β-Catenin Degradation

  Jungsug Gwak, Jingyo Oh, Munju Cho, Soo Kyung Bae, Im-Sook Song, Kwang-Hyeon Liu, Yongsu Jeong, Dong-Eun Kim, Young-Hwa Chung and Sangtaek Oh

  Molecular Pharmacology June 2011, 79 (6) 1014-1022; DOI: https://doi.org/10.1124/mol.110.069591
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  Rapid and Contrasting Effects of Rosiglitazone on Transient Receptor Potential TRPM3 and TRPC5 Channels

  Yasser Majeed, Yahya Bahnasi, Victoria A. L. Seymour, Lesley A. Wilson, Carol J. Milligan, Anil K. Agarwal, Piruthivi Sukumar, Jacqueline Naylor and David J. Beech

  Molecular Pharmacology June 2011, 79 (6) 1023-1030; DOI: https://doi.org/10.1124/mol.110.069922
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  Selective Toxicity of the Anthelmintic Emodepside Revealed by Heterologous Expression of Human KCNMA1 in Caenorhabditis elegans

  Anna Crisford, Caitriona Murray, Vincent O'Connor, Richard J. Edwards, Nina Kruger, Claudia Welz, Georg von Samson-Himmelstjerna, Achim Harder, Robert J. Walker and Lindy Holden-Dye

  Molecular Pharmacology June 2011, 79 (6) 1031-1043; DOI: https://doi.org/10.1124/mol.111.071043
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  G Protein-Coupled Receptor Heteromerization: A Role in Allosteric Modulation of Ligand Binding

  Ivone Gomes, Adriaan P. IJzerman, Kai Ye, Emeline L. Maillet and Lakshmi A. Devi

  Molecular Pharmacology June 2011, 79 (6) 1044-1052; DOI: https://doi.org/10.1124/mol.110.070847
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  Inhibition of Human UGT2B7 Gene Expression in Transgenic Mice by the Constitutive Androstane Receptor

  M. F. Yueh, P. L. Mellon and R. H. Tukey

  Molecular Pharmacology June 2011, 79 (6) 1053-1060; DOI: https://doi.org/10.1124/mol.110.070649
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  κ-Opioid Receptor Inhibition of Calcium Oscillations in Spinal Cord Neurons

  Lakshmi Kelamangalath, Shashank M. Dravid, Joju George, Jane V. Aldrich and Thomas F. Murray

  Molecular Pharmacology June 2011, 79 (6) 1061-1071; DOI: https://doi.org/10.1124/mol.111.071456
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  Bcl-xL Is a Dominant Antiapoptotic Protein that Inhibits Homoharringtonine-Induced Apoptosis in Leukemia Cells

  Shiliang Yin, Rui Wang, Fan Zhou, Hong Zhang and Yongkui Jing

  Molecular Pharmacology June 2011, 79 (6) 1072-1083; DOI: https://doi.org/10.1124/mol.110.068528