Abstract
Quantum-mechanical calculations have been performed, by the method of perturbative configuration interaction using localized orbitals, on the conformational properties of models for local anesthetics belonging to the class of esters of the general formula
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for n = 1, 2, 3, and for the anilide drug lidocaine. The results indicate that in spite of the different numbers of intermediate carbons, the distances between the carbonyl and amino groups of the esters are similar in some of their stable conformations. This suggests that they may react with the same receptor.
- Copyright ©, 1972, by Academic Press, Inc.
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