Abstract
The effects of the hepatotoxin and carcinogen, thioacetamide, on several hepatic mixed-function oxidases and the microsomal cytochrome content were examined following a single challenge with the toxin. Most of the metabolic pathways tested were deranged early in the course of the intoxication, and remained thus during the entire week of observation. The hepatic content of cytochromes P-450 and b5 decreased; the activities of aryl hydrocarbon hydroxylase, N-demethylase, N-oxidase, and lipid peroxidase also declined. NADPH2-neotetrazolium reductase activity diminished later, and to a lesser degree, than the above activities. Comparison of these changes with those observed following either carbon tetrachloride administration or partial surgical hepatectomy revealed several differences in the patterns of the responses. Results were obtained which suggest that the formation of formaldehyde and N,N-dimethylaniline N-oxide from N,N-dimethylaniline may proceed by separate and distinct pathways.
- Copyright ©, 1972, by Academic Press, Inc.
MolPharm articles become freely available 12 months after publication, and remain freely available for 5 years.Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page.
|