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Molecular Pharmacology

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Table of Contents

October 01, 2011; Volume 80,Issue 4

Minireviews

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    Understanding Molecular Recognition by G protein βγ Subunits on the Path to Pharmacological Targeting
    Yuan Lin and Alan V. Smrcka
    Molecular Pharmacology October 2011, 80 (4) 551-557; DOI: https://doi.org/10.1124/mol.111.073072
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    MicroRNAs: New Players in Cardiac Injury and Protection
    Rakesh C. Kukreja, Chang Yin and Fadi N. Salloum
    Molecular Pharmacology October 2011, 80 (4) 558-564; DOI: https://doi.org/10.1124/mol.111.073528

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    Structural and Functional Analyses of the Second-Generation Integrase Strand Transfer Inhibitor Dolutegravir (S/GSK1349572)
    Stephen Hare, Steven J. Smith, Mathieu Métifiot, Albert Jaxa-Chamiec, Yves Pommier, Stephen H. Hughes and Peter Cherepanov
    Molecular Pharmacology October 2011, 80 (4) 565-572; DOI: https://doi.org/10.1124/mol.111.073189

Articles

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    Interactions of Key Charged Residues Contributing to Selective Block of Neuronal Sodium Channels by μ-Conotoxin KIIIA
    J. R. McArthur, G. Singh, D. McMaster, R. Winkfein, D. P. Tieleman and R. J. French
    Molecular Pharmacology October 2011, 80 (4) 573-584; DOI: https://doi.org/10.1124/mol.111.073460
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    Elucidation of the Contribution of Active Site and Exosite Interactions to Affinity and Specificity of Peptidylic Serine Protease Inhibitors Using Non-Natural Arginine Analogs
    Masood Hosseini, Longguang Jiang, Hans Peter Sørensen, Jan K. Jensen, Anni Christensen, Sarah Fogh, Cai Yuan, Lisbeth M. Andersen, Mingdong Huang, Peter A. Andreasen and Knud J. Jensen
    Molecular Pharmacology October 2011, 80 (4) 585-597; DOI: https://doi.org/10.1124/mol.111.072280
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    Novel Thiosemicarbazone Iron Chelators Induce Up-Regulation and Phosphorylation of the Metastasis Suppressor N-myc Down-Stream Regulated Gene 1: A New Strategy for the Treatment of Pancreatic Cancer
    Zaklina Kovacevic, Sherin Chikhani, David B. Lovejoy and Des R. Richardson
    Molecular Pharmacology October 2011, 80 (4) 598-609; DOI: https://doi.org/10.1124/mol.111.073627
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    The Selective Estrogen Receptor Modulator Bazedoxifene Inhibits Hormone-Independent Breast Cancer Cell Growth and Down-Regulates Estrogen Receptor α and Cyclin D1
    Joan S. Lewis-Wambi, Helen Kim, Ramona Curpan, Ronald Grigg, Mohammed A. Sarker and V. Craig Jordan
    Molecular Pharmacology October 2011, 80 (4) 610-620; DOI: https://doi.org/10.1124/mol.111.072249
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    The Antiepileptic Drugs Phenobarbital and Carbamazepine Reduce Transport of Methotrexate in Rat Choroid Plexus by Down-Regulation of the Reduced Folate Carrier
    Sandra Halwachs, Cathleen Lakoma, Ingo Schäfer, Peter Seibel and Walther Honscha
    Molecular Pharmacology October 2011, 80 (4) 621-629; DOI: https://doi.org/10.1124/mol.111.072421
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    Molecular Determinants for Activation of Human Ether-à-go-go-related Gene 1 Potassium Channels by 3-Nitro-N-(4-phenoxyphenyl) Benzamide
    Vivek Garg, Anna Stary-Weinzinger, Frank Sachse and Michael C. Sanguinetti
    Molecular Pharmacology October 2011, 80 (4) 630-637; DOI: https://doi.org/10.1124/mol.111.073809
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    Curcumin-Induced Mitotic Spindle Defect and Cell Cycle Arrest in Human Bladder Cancer Cells Occurs Partly through Inhibition of Aurora A
    Hsiao-Sheng Liu, Ching-Shiun Ke, Hung-Chi Cheng, Chi-Ying F. Huang and Chun-Li Su
    Molecular Pharmacology October 2011, 80 (4) 638-646; DOI: https://doi.org/10.1124/mol.111.072512
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    Three Arginines in the GABAA Receptor Binding Pocket Have Distinct Roles in the Formation and Stability of Agonist- versus Antagonist-Bound Complexes
    Marcel P. Goldschen-Ohm, David A. Wagner and Mathew V. Jones
    Molecular Pharmacology October 2011, 80 (4) 647-656; DOI: https://doi.org/10.1124/mol.111.072033
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    Isoform-Selective Inhibition of Phosphoinositide 3-Kinase: Identification of a New Region of Nonconserved Amino Acids Critical for p110α Inhibition
    Zhaohua Zheng, Syazwani I. Amran, Philip E. Thompson and Ian G. Jennings
    Molecular Pharmacology October 2011, 80 (4) 657-664; DOI: https://doi.org/10.1124/mol.111.072546
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    Cooperative Role of Caveolin-1 and C-Terminal Src Kinase Binding Protein in C-Terminal Src Kinase-Mediated Negative Regulation of c-Src
    Aaron T. Place, Zhenlong Chen, Farnaz R. Bakhshi, Guoquan Liu, John P. O'Bryan and Richard D. Minshall
    Molecular Pharmacology October 2011, 80 (4) 665-672; DOI: https://doi.org/10.1124/mol.111.073957
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    Aryl Hydrocarbon Receptor Activation in Hematopoietic Stem/Progenitor Cells Alters Cell Function and Pathway-Specific Gene Modulation Reflecting Changes in Cellular Trafficking and Migration
    Fanny L. Casado, Kameshwar P. Singh and Thomas A. Gasiewicz
    Molecular Pharmacology October 2011, 80 (4) 673-682; DOI: https://doi.org/10.1124/mol.111.071381
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    Cyanoquinolines with Independent Corrector and Potentiator Activities Restore ΔPhe508-Cystic Fibrosis Transmembrane Conductance Regulator Chloride Channel Function in Cystic Fibrosis
    Puay-Wah Phuan, Baoxue Yang, John M. Knapp, Alex B. Wood, Gergely L. Lukacs, Mark J. Kurth and A. S. Verkman
    Molecular Pharmacology October 2011, 80 (4) 683-693; DOI: https://doi.org/10.1124/mol.111.073056
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    Novel Betulin Derivatives as Antileishmanial Agents with Mode of Action Targeting Type IB DNA Topoisomerase
    Sayan Chowdhury, Tulika Mukherjee, Souvik Sengupta, Somenath Roy Chowdhury, Sibabrata Mukhopadhyay and Hemanta K. Majumder
    Molecular Pharmacology October 2011, 80 (4) 694-703; DOI: https://doi.org/10.1124/mol.111.072785
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    Rat Embryo Exposure to All-Trans Retinoic Acid Results in Postnatal Oxidative Damage of Respiratory Complex I in the Cerebellum
    Anna Signorile, Nicola Sardaro, Domenico De Rasmo, Salvatore Scacco, Francesco Papa, Pietro Borracci, Maria Rosaria Carratù and Sergio Papa
    Molecular Pharmacology October 2011, 80 (4) 704-713; DOI: https://doi.org/10.1124/mol.111.073353
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    Valproic Acid Induces Monoamine Oxidase A via Akt/Forkhead Box O1 Activation
    Jason Boyang Wu and Jean C. Shih
    Molecular Pharmacology October 2011, 80 (4) 714-723; DOI: https://doi.org/10.1124/mol.111.072744
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    Inhibition of Navβ4 Peptide-Mediated Resurgent Sodium Currents in Nav1.7 Channels by Carbamazepine, Riluzole, and Anandamide
    Jonathan W. Theile and Theodore R. Cummins
    Molecular Pharmacology October 2011, 80 (4) 724-734; DOI: https://doi.org/10.1124/mol.111.072751
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    Identification of Cysteines Involved in the Effects of Methanethiosulfonate Reagents on Human Equilibrative Nucleoside Transporter 1
    Jamie S. Park, Scott J. Hughes, Frances K. M. Cunningham and James R. Hammond
    Molecular Pharmacology October 2011, 80 (4) 735-746; DOI: https://doi.org/10.1124/mol.111.072587
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    Long-Term α1A-Adrenergic Receptor Stimulation Improves Synaptic Plasticity, Cognitive Function, Mood, and Longevity
    Van A. Doze, Robert S. Papay, Brianna L. Goldenstein, Manveen K. Gupta, Katie M. Collette, Brian W. Nelson, Mariaha J. Lyons, Bethany A. Davis, Elizabeth J. Luger, Sarah G. Wood, James R. Haselton, Paul C. Simpson and Dianne M. Perez
    Molecular Pharmacology October 2011, 80 (4) 747-758; DOI: https://doi.org/10.1124/mol.111.073734
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In this issue

Molecular Pharmacology: 80 (4)
Molecular Pharmacology
Vol. 80, Issue 4
1 Oct 2011
  • Table of Contents
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  • The G-Protein-Coupled Receptors in the Human Genome Form Five Main Families. Phylogenetic Analysis, Paralogon Groups, and Fingerprints
  • Pharmacological Properties of Y-27632, a Specific Inhibitor of Rho-Associated Kinases
  • Pharmacological characterization of five cloned voltage-gated K+ channels, types Kv1.1, 1.2, 1.3, 1.5, and 3.1, stably expressed in mammalian cell lines.
  • The Orphan Human Pregnane X Receptor Mediates the Transcriptional Activation of CYP3A4 by Rifampicin through a Distal Enhancer Module
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