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Molecular Pharmacology

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Table of Contents

November 01, 2011; Volume 80,Issue 5

Announcement

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    Announcement
    James E. Barrett
    Molecular Pharmacology November 2011, 80 (5) 759; DOI: https://doi.org/10.1124/mol.80.5.759

Minireview

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    β-Arrestin-Dependent Actin Reorganization: Bringing the Right Players Together at the Leading Edge
    Jungah Min and Kathryn DeFea
    Molecular Pharmacology November 2011, 80 (5) 760-768; DOI: https://doi.org/10.1124/mol.111.072470

Articles

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    Bharangin, a Diterpenoid Quinonemethide, Abolishes Constitutive and Inducible Nuclear Factor-κB (NF-κB) Activation by Modifying p65 on Cysteine 38 Residue and Reducing Inhibitor of Nuclear Factor-κB α Kinase Activation, Leading to Suppression of NF-κB-Regulated Gene Expression and Sensitization of Tumor Cells to Chemotherapeutic Agents
    Subash C. Gupta, Ramaswamy Kannappan, Jihye Kim, Ghazi M. Rahman, Sajin K. Francis, Reshma Raveendran, Mangalam S. Nair, Joydip Das and Bharat B. Aggarwal
    Molecular Pharmacology November 2011, 80 (5) 769-781; DOI: https://doi.org/10.1124/mol.111.073122
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    Mechanism for Noncompetitive Inhibition by Novel GluN2C/D N-Methyl-d-aspartate Receptor Subunit-Selective Modulators
    Timothy M. Acker, Hongjie Yuan, Kasper B. Hansen, Katie M. Vance, Kevin K. Ogden, Henrik S. Jensen, Pieter B. Burger, Praseeda Mullasseril, James P. Snyder, Dennis C. Liotta and Stephen F. Traynelis
    Molecular Pharmacology November 2011, 80 (5) 782-795; DOI: https://doi.org/10.1124/mol.111.073239
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    A Dynamic Pharmacophore Drives the Interaction between Psalmotoxin-1 and the Putative Drug Target Acid-Sensing Ion Channel 1a
    Natalie J. Saez, Mehdi Mobli, Michael Bieri, Irène R. Chassagnon, Alpeshkumar K. Malde, Roland Gamsjaeger, Alan E. Mark, Paul R. Gooley, Lachlan D. Rash and Glenn F. King
    Molecular Pharmacology November 2011, 80 (5) 796-808; DOI: https://doi.org/10.1124/mol.111.072207
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    Expression and Distribution of Nucleoside Transporter Proteins in the Human Syncytiotrophoblast
    Ekaitz Errasti-Murugarren, Paula Díaz, Valeria Godoy, Gloria Riquelme and Marçal Pastor-Anglada
    Molecular Pharmacology November 2011, 80 (5) 809-817; DOI: https://doi.org/10.1124/mol.111.071837
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    Functional Characterization of the α5(Asn398) Variant Associated with Risk for Nicotine Dependence in the α3β4α5 Nicotinic Receptor
    Ping Li, Megan McCollum, John Bracamontes, Joe Henry Steinbach and Gustav Akk
    Molecular Pharmacology November 2011, 80 (5) 818-827; DOI: https://doi.org/10.1124/mol.111.073841
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    High-Affinity Peroxisome Proliferator-Activated Receptor β/δ-Specific Ligands with Pure Antagonistic or Inverse Agonistic Properties
    Simone Naruhn, Philipp M. Toth, Till Adhikary, Kerstin Kaddatz, Veronika Pape, Stefanie Dörr, Gerhard Klebe, Sabine Müller-Brüsselbach, Wibke E. Diederich and Rolf Müller
    Molecular Pharmacology November 2011, 80 (5) 828-838; DOI: https://doi.org/10.1124/mol.111.074039
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    Mechanism-Based Inactivation of Human Cytochrome P450 2B6 by Clopidogrel: Involvement of Both Covalent Modification of Cysteinyl Residue 475 and Loss of Heme
    Haoming Zhang, Hemali Amunugama, Sarah Ney, Nyemade Cooper and Paul F. Hollenberg
    Molecular Pharmacology November 2011, 80 (5) 839-847; DOI: https://doi.org/10.1124/mol.111.073783
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    Study of GPR81, the Lactate Receptor, from Distant Species Identifies Residues and Motifs Critical for GPR81 Functions
    Chester Kuei, Jingxue Yu, Jessica Zhu, Jiejun Wu, Li Zhang, Amy Shih, Taraneh Mirzadegan, Timothy Lovenberg and Changlu Liu
    Molecular Pharmacology November 2011, 80 (5) 848-858; DOI: https://doi.org/10.1124/mol.111.074500
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    Rimonabant, a Cannabinoid Receptor Type 1 Inverse Agonist, Inhibits Hepatocyte Lipogenesis by Activating Liver Kinase B1 and AMP-Activated Protein Kinase Axis Downstream of Gαi/o Inhibition
    Hong Min Wu, Yoon Mee Yang and Sang Geon Kim
    Molecular Pharmacology November 2011, 80 (5) 859-869; DOI: https://doi.org/10.1124/mol.111.072769
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    Sulforaphane Suppresses Polycomb Group Protein Level via a Proteasome-Dependent Mechanism in Skin Cancer Cells
    Sivaprakasam Balasubramanian, Yap Ching Chew and Richard L. Eckert
    Molecular Pharmacology November 2011, 80 (5) 870-878; DOI: https://doi.org/10.1124/mol.111.072363
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    Application of Homology Modeling to Generate CYP1A1 Mutants with Enhanced Activation of the Cancer Chemotherapeutic Prodrug Dacarbazine
    Benjamin C. Lewis, Peter I. Mackenzie and John O. Miners
    Molecular Pharmacology November 2011, 80 (5) 879-888; DOI: https://doi.org/10.1124/mol.111.072124
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    Dihydroxypentamethoxyflavone Down-Regulates Constitutive and Inducible Signal Transducers and Activators of Transcription-3 through the Induction of Tyrosine Phosphatase SHP-1
    Kanokkarn Phromnoi, Sahdeo Prasad, Subash C. Gupta, Ramaswamy Kannappan, Simone Reuter, Pornngarm Limtrakul and Bharat B. Aggarwal
    Molecular Pharmacology November 2011, 80 (5) 889-899; DOI: https://doi.org/10.1124/mol.111.073676
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    TTA-P2 Is a Potent and Selective Blocker of T-Type Calcium Channels in Rat Sensory Neurons and a Novel Antinociceptive Agent
    WonJoo Choe, Richard B. Messinger, Emily Leach, Veit-Simon Eckle, Aleksandar Obradovic, Reza Salajegheh, Vesna Jevtovic-Todorovic and Slobodan M. Todorovic
    Molecular Pharmacology November 2011, 80 (5) 900-910; DOI: https://doi.org/10.1124/mol.111.073205
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    The Pharmacological Profile of Brain Liver Intestine Na+ Channel: Inhibition by Diarylamidines and Activation by Fenamates
    Dominik Wiemuth and Stefan Gründer
    Molecular Pharmacology November 2011, 80 (5) 911-919; DOI: https://doi.org/10.1124/mol.111.073726
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    Duration of Action of a Broad Range of Selective κ-Opioid Receptor Antagonists Is Positively Correlated with c-Jun N-Terminal Kinase-1 Activation
    Erica J. Melief, Mayumi Miyatake, F. Ivy Carroll, Cécile Béguin, William A. Carlezon, Bruce M. Cohen, Sarah Grimwood, Charles H. Mitch, Linda Rorick-Kehn and Charles Chavkin
    Molecular Pharmacology November 2011, 80 (5) 920-929; DOI: https://doi.org/10.1124/mol.111.074195
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    Strong Activation of ether-à-go-go-Related Gene 1 K+ Channel Isoforms by NS1643 in Human Embryonic Kidney 293 and Chinese Hamster Ovary Cells
    Anna M. Schuster, Günter Glassmeier and Christiane K. Bauer
    Molecular Pharmacology November 2011, 80 (5) 930-942; DOI: https://doi.org/10.1124/mol.111.071621
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    Dietary 9-cis-β,β-Carotene Fails to Rescue Vision in Mouse Models of Leber Congenital Amaurosis
    Tadao Maeda, Lindsay Perusek, Jaume Amengual, Darwin Babino, Krzysztof Palczewski and Johannes von Lintig
    Molecular Pharmacology November 2011, 80 (5) 943-952; DOI: https://doi.org/10.1124/mol.111.074732

Erratum

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    Correction to “Characterization of an NBS1 C-Terminal Peptide That Can Inhibit Ataxia Telangiectasia Mutated (ATM)-Mediated DNA Damage Responses and Enhance Radiosensitivity”
    Molecular Pharmacology November 2011, 80 (5) 953; DOI: https://doi.org/10.1124/mol.80.5.953
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Molecular Pharmacology: 80 (5)
Molecular Pharmacology
Vol. 80, Issue 5
1 Nov 2011
  • Table of Contents
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  • Pharmacological Properties of Y-27632, a Specific Inhibitor of Rho-Associated Kinases
  • Pharmacological characterization of five cloned voltage-gated K+ channels, types Kv1.1, 1.2, 1.3, 1.5, and 3.1, stably expressed in mammalian cell lines.
  • The Orphan Human Pregnane X Receptor Mediates the Transcriptional Activation of CYP3A4 by Rifampicin through a Distal Enhancer Module
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