Table of Contents

Articles

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  Bharangin, a Diterpenoid Quinonemethide, Abolishes Constitutive and Inducible Nuclear Factor-κB (NF-κB) Activation by Modifying p65 on Cysteine 38 Residue and Reducing Inhibitor of Nuclear Factor-κB α Kinase Activation, Leading to Suppression of NF-κB-Regulated Gene Expression and Sensitization of Tumor Cells to Chemotherapeutic Agents

  Subash C. Gupta, Ramaswamy Kannappan, Jihye Kim, Ghazi M. Rahman, Sajin K. Francis, Reshma Raveendran, Mangalam S. Nair, Joydip Das and Bharat B. Aggarwal

  Molecular Pharmacology November 2011, 80 (5) 769-781; DOI: https://doi.org/10.1124/mol.111.073122
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  Mechanism for Noncompetitive Inhibition by Novel GluN2C/D N-Methyl-d-aspartate Receptor Subunit-Selective Modulators

  Timothy M. Acker, Hongjie Yuan, Kasper B. Hansen, Katie M. Vance, Kevin K. Ogden, Henrik S. Jensen, Pieter B. Burger, Praseeda Mullasseril, James P. Snyder, Dennis C. Liotta and Stephen F. Traynelis

  Molecular Pharmacology November 2011, 80 (5) 782-795; DOI: https://doi.org/10.1124/mol.111.073239
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  A Dynamic Pharmacophore Drives the Interaction between Psalmotoxin-1 and the Putative Drug Target Acid-Sensing Ion Channel 1a

  Natalie J. Saez, Mehdi Mobli, Michael Bieri, Irène R. Chassagnon, Alpeshkumar K. Malde, Roland Gamsjaeger, Alan E. Mark, Paul R. Gooley, Lachlan D. Rash and Glenn F. King

  Molecular Pharmacology November 2011, 80 (5) 796-808; DOI: https://doi.org/10.1124/mol.111.072207
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  Expression and Distribution of Nucleoside Transporter Proteins in the Human Syncytiotrophoblast

  Ekaitz Errasti-Murugarren, Paula Díaz, Valeria Godoy, Gloria Riquelme and Marçal Pastor-Anglada

  Molecular Pharmacology November 2011, 80 (5) 809-817; DOI: https://doi.org/10.1124/mol.111.071837
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  Functional Characterization of the α5(Asn398) Variant Associated with Risk for Nicotine Dependence in the α3β4α5 Nicotinic Receptor

  Ping Li, Megan McCollum, John Bracamontes, Joe Henry Steinbach and Gustav Akk

  Molecular Pharmacology November 2011, 80 (5) 818-827; DOI: https://doi.org/10.1124/mol.111.073841
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  High-Affinity Peroxisome Proliferator-Activated Receptor β/δ-Specific Ligands with Pure Antagonistic or Inverse Agonistic Properties

  Simone Naruhn, Philipp M. Toth, Till Adhikary, Kerstin Kaddatz, Veronika Pape, Stefanie Dörr, Gerhard Klebe, Sabine Müller-Brüsselbach, Wibke E. Diederich and Rolf Müller

  Molecular Pharmacology November 2011, 80 (5) 828-838; DOI: https://doi.org/10.1124/mol.111.074039
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  Mechanism-Based Inactivation of Human Cytochrome P450 2B6 by Clopidogrel: Involvement of Both Covalent Modification of Cysteinyl Residue 475 and Loss of Heme

  Haoming Zhang, Hemali Amunugama, Sarah Ney, Nyemade Cooper and Paul F. Hollenberg

  Molecular Pharmacology November 2011, 80 (5) 839-847; DOI: https://doi.org/10.1124/mol.111.073783
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  Study of GPR81, the Lactate Receptor, from Distant Species Identifies Residues and Motifs Critical for GPR81 Functions

  Chester Kuei, Jingxue Yu, Jessica Zhu, Jiejun Wu, Li Zhang, Amy Shih, Taraneh Mirzadegan, Timothy Lovenberg and Changlu Liu

  Molecular Pharmacology November 2011, 80 (5) 848-858; DOI: https://doi.org/10.1124/mol.111.074500
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  Rimonabant, a Cannabinoid Receptor Type 1 Inverse Agonist, Inhibits Hepatocyte Lipogenesis by Activating Liver Kinase B1 and AMP-Activated Protein Kinase Axis Downstream of Gα_i/o Inhibition

  Hong Min Wu, Yoon Mee Yang and Sang Geon Kim

  Molecular Pharmacology November 2011, 80 (5) 859-869; DOI: https://doi.org/10.1124/mol.111.072769
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  Sulforaphane Suppresses Polycomb Group Protein Level via a Proteasome-Dependent Mechanism in Skin Cancer Cells

  Sivaprakasam Balasubramanian, Yap Ching Chew and Richard L. Eckert

  Molecular Pharmacology November 2011, 80 (5) 870-878; DOI: https://doi.org/10.1124/mol.111.072363
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  Application of Homology Modeling to Generate CYP1A1 Mutants with Enhanced Activation of the Cancer Chemotherapeutic Prodrug Dacarbazine

  Benjamin C. Lewis, Peter I. Mackenzie and John O. Miners

  Molecular Pharmacology November 2011, 80 (5) 879-888; DOI: https://doi.org/10.1124/mol.111.072124
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  Dihydroxypentamethoxyflavone Down-Regulates Constitutive and Inducible Signal Transducers and Activators of Transcription-3 through the Induction of Tyrosine Phosphatase SHP-1

  Kanokkarn Phromnoi, Sahdeo Prasad, Subash C. Gupta, Ramaswamy Kannappan, Simone Reuter, Pornngarm Limtrakul and Bharat B. Aggarwal

  Molecular Pharmacology November 2011, 80 (5) 889-899; DOI: https://doi.org/10.1124/mol.111.073676
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  TTA-P2 Is a Potent and Selective Blocker of T-Type Calcium Channels in Rat Sensory Neurons and a Novel Antinociceptive Agent

  WonJoo Choe, Richard B. Messinger, Emily Leach, Veit-Simon Eckle, Aleksandar Obradovic, Reza Salajegheh, Vesna Jevtovic-Todorovic and Slobodan M. Todorovic

  Molecular Pharmacology November 2011, 80 (5) 900-910; DOI: https://doi.org/10.1124/mol.111.073205
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  The Pharmacological Profile of Brain Liver Intestine Na⁺ Channel: Inhibition by Diarylamidines and Activation by Fenamates

  Dominik Wiemuth and Stefan Gründer

  Molecular Pharmacology November 2011, 80 (5) 911-919; DOI: https://doi.org/10.1124/mol.111.073726
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  Duration of Action of a Broad Range of Selective κ-Opioid Receptor Antagonists Is Positively Correlated with c-Jun N-Terminal Kinase-1 Activation

  Erica J. Melief, Mayumi Miyatake, F. Ivy Carroll, Cécile Béguin, William A. Carlezon, Bruce M. Cohen, Sarah Grimwood, Charles H. Mitch, Linda Rorick-Kehn and Charles Chavkin

  Molecular Pharmacology November 2011, 80 (5) 920-929; DOI: https://doi.org/10.1124/mol.111.074195
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  Strong Activation of ether-à-go-go-Related Gene 1 K⁺ Channel Isoforms by NS1643 in Human Embryonic Kidney 293 and Chinese Hamster Ovary Cells

  Anna M. Schuster, Günter Glassmeier and Christiane K. Bauer

  Molecular Pharmacology November 2011, 80 (5) 930-942; DOI: https://doi.org/10.1124/mol.111.071621
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  Dietary 9-cis-β,β-Carotene Fails to Rescue Vision in Mouse Models of Leber Congenital Amaurosis

  Tadao Maeda, Lindsay Perusek, Jaume Amengual, Darwin Babino, Krzysztof Palczewski and Johannes von Lintig

  Molecular Pharmacology November 2011, 80 (5) 943-952; DOI: https://doi.org/10.1124/mol.111.074732