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Research ArticleArticle

Application of Homology Modeling to Generate CYP1A1 Mutants with Enhanced Activation of the Cancer Chemotherapeutic Prodrug Dacarbazine

Benjamin C. Lewis, Peter I. Mackenzie and John O. Miners
Molecular Pharmacology November 2011, 80 (5) 879-888; DOI: https://doi.org/10.1124/mol.111.072124

Article Information

vol. 80 no. 5 879-888
DOI 
https://doi.org/10.1124/mol.111.072124
PubMed 
21816953
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received March 6, 2011
  • Accepted August 3, 2011
  • Published online October 19, 2011.

Article Versions

Copyright & Usage 
Copyright © 2011 The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Benjamin C. Lewis,
  2. Peter I. Mackenzie and
  3. John O. Miners
  1. Department of Clinical Pharmacology, School of Medicine, Flinders University, Adelaide, Australia
  1. Address correspondence to:
    Prof. John Miners, Department of Clinical Pharmacology, Flinders University School of Medicine, Flinders Medical Centre, Bedford Park, SA 5042, Australia. E-mail: john.miners{at}flinders.edu.au
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Research ArticleArticle

Activation of Dacarbazine by CYP1A1 Mutants

Benjamin C. Lewis, Peter I. Mackenzie and John O. Miners
Molecular Pharmacology November 1, 2011, 80 (5) 879-888; DOI: https://doi.org/10.1124/mol.111.072124
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