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Developing Chemical Genetic Approaches to Explore G Protein-Coupled Receptor Function: Validation of the Use of a Receptor Activated Solely by Synthetic Ligand (RASSL)

Elisa Alvarez-Curto, Rudi Prihandoko, Christofer S. Tautermann, Jurriaan M. Zwier, John D. Pediani, Martin J. Lohse, Carsten Hoffmann, Andrew B. Tobin and Graeme Milligan
Molecular Pharmacology December 2011, 80 (6) 1033-1046; DOI: https://doi.org/10.1124/mol.111.074674

Article Information

vol. 80 no. 6 1033-1046
DOI 
https://doi.org/10.1124/mol.111.074674
PubMed 
21880827
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received July 8, 2011
  • Accepted August 30, 2011
  • Published online November 18, 2011.

Article Versions

Copyright & Usage 
Copyright © 2011 The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Elisa Alvarez-Curto,
  2. Rudi Prihandoko,
  3. Christofer S. Tautermann,
  4. Jurriaan M. Zwier,
  5. John D. Pediani,
  6. Martin J. Lohse,
  7. Carsten Hoffmann,
  8. Andrew B. Tobin and
  9. Graeme Milligan
  1. Molecular Pharmacology Group, Institute of Neuroscience and Psychology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom (E.A.-C., J.D.P., G.M.); Department of Cell Physiology and Pharmacology, University of Leicester, Leicester England, United Kingdom (R.P., A.B.T.); Lead Identification and Optimization Support, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach, Germany (C.S.T.); Cisbio Bioassays, Codolet, France (J.M.Z.); and Department of Pharmacology and Toxicology, University of Wuerzburg, Wuerzburg, Germany (M.J.L., C.H.)
  1. Address correspondence to:
    Graeme Milligan, Wolfson Link Building 253, University of Glasgow, Glasgow G12 8QQ, Scotland, UK, E-mail: graeme.milligan{at}glasgow.ac.uk
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Muscarinic RASSL Function

Elisa Alvarez-Curto, Rudi Prihandoko, Christofer S. Tautermann, Jurriaan M. Zwier, John D. Pediani, Martin J. Lohse, Carsten Hoffmann, Andrew B. Tobin and Graeme Milligan
Molecular Pharmacology December 1, 2011, 80 (6) 1033-1046; DOI: https://doi.org/10.1124/mol.111.074674
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