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Research ArticleArticle

Identification of a Novel Allosteric Binding Site in the CXCR2 Chemokine Receptor

Petra de Kruijf, Herman D. Lim, Luc Roumen, Véronique A. Renjaän, Jiuqiao Zhao, Maria L. Webb, Douglas S. Auld, Jac. C.H.M. Wijkmans, Guido J. R. Zaman, Martine J. Smit, Chris de Graaf and Rob Leurs
Molecular Pharmacology December 2011, 80 (6) 1108-1118; DOI: https://doi.org/10.1124/mol.111.073825

Article Information

vol. 80 no. 6 1108-1118
DOI 
https://doi.org/10.1124/mol.111.073825
PubMed 
21948388
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received May 27, 2011
  • Accepted September 23, 2011
  • Published online November 18, 2011.

Article Versions

Copyright & Usage 
Copyright © 2011 The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Petra de Kruijf,
  2. Herman D. Lim,
  3. Luc Roumen,
  4. Véronique A. Renjaän,
  5. Jiuqiao Zhao1,
  6. Maria L. Webb2,
  7. Douglas S. Auld3,
  8. Jac. C.H.M. Wijkmans,
  9. Guido J. R. Zaman,
  10. Martine J. Smit,
  11. Chris de Graaf and
  12. Rob Leurs
  1. Leiden/Amsterdam Center for Drug Research, Division of Medicinal Chemistry, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands (P.d.K., H.D.L., L.R., V.A.R., C.d.G., M.J.S., R.L.); Merck Research Laboratories, MSD, Oss, The Netherlands (J.C.H.M.W., G.J.R.Z.); and Pharmacopeia Drug Discovery, Inc., Princeton, New Jersey (J.Z., M.L.W., D.S.A.)
  1. Address correspondence to:
    Rob Leurs, Leiden/Amsterdam Center of Drug Research, Faculty of Science, Vrije Universiteit Amsterdam, De Boelelaan 1083, 1081 HV Amsterdam, The Netherlands. E-mail: r.leurs{at}few.vu.nl

  1. P.d.K., H.D.L., and L.R. contributed equally to this work.

  • ↵1 Current affiliation: JBristol-Myers Squibb Company, Wallingford, Connecticut.

  • ↵2 Current affiliation: Venenum, Genesis Biotechnology Group, Trenton, New Jersey.

  • ↵3 Current affiliation: Novartis Institutes for BioMedical Research Center for Proteomic Chemistry, Cambridge, Massachusetts.

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Binding Pocket Imidazolylpyrimidine Compound at CXCR2

Petra de Kruijf, Herman D. Lim, Luc Roumen, Véronique A. Renjaän, Jiuqiao Zhao, Maria L. Webb, Douglas S. Auld, Jac. C.H.M. Wijkmans, Guido J. R. Zaman, Martine J. Smit, Chris de Graaf and Rob Leurs
Molecular Pharmacology December 1, 2011, 80 (6) 1108-1118; DOI: https://doi.org/10.1124/mol.111.073825
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