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Research ArticleArticle

Pharmacokinetic and Pharmacodynamic Properties of the Glucokinase Activator MK-0941 in Rodent Models of Type 2 Diabetes and Healthy Dogs

Jun-ichi Eiki, Yasufumi Nagata, Mayumi Futamura, Kaori Sasaki-Yamamoto, Tomoharu Iino, Teruyuki Nishimura, Masato Chiba, Sumika Ohyama, Riki Yoshida-Yoshimioto, Kenji Fujii, Hideka Hosaka, Hiroko Goto-Shimazaki, Akito Kadotani, Tomoyuki Ohe, Songnian Lin, Ronald B. Langdon and Joel P. Berger
Molecular Pharmacology December 2011, 80 (6) 1156-1165; DOI: https://doi.org/10.1124/mol.111.074401

Article Information

vol. 80 no. 6 1156-1165
DOI 
https://doi.org/10.1124/mol.111.074401
PubMed 
21937665
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received June 29, 2011
  • Accepted September 21, 2011
  • Published online November 18, 2011.

Article Versions

Copyright & Usage 
Copyright © 2011 The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Jun-ichi Eiki,
  2. Yasufumi Nagata,
  3. Mayumi Futamura,
  4. Kaori Sasaki-Yamamoto,
  5. Tomoharu Iino,
  6. Teruyuki Nishimura,
  7. Masato Chiba,
  8. Sumika Ohyama,
  9. Riki Yoshida-Yoshimioto,
  10. Kenji Fujii,
  11. Hideka Hosaka,
  12. Hiroko Goto-Shimazaki,
  13. Akito Kadotani,
  14. Tomoyuki Ohe,
  15. Songnian Lin,
  16. Ronald B. Langdon and
  17. Joel P. Berger
  1. Tsukuba Research Institute, Banyu Pharmaceutical Co., Ltd., Tsukuba, Ibaraki, Japan (J.E., Y.N., M.F., K.S.-Y., T.I., T.N., M.C., S.O., R.Y.-Y., K.F., H.H., H.G.-S., A.K., T.O.); and Merck Research Laboratories, Rahway, New Jersey (S.L., R.B.L., J.P.B.)
  1. Address correspondence to:
    Jun-ichi Eiki, Kitanomaru Square 1-13-12, Kudan-Kita, Chiyoda-Ku, Tokyo, 102-8667 Japan. E-mail: junichi_eiki{at}merck.com
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Preclinical PK/PD of the Glucokinase Activator MK-0941

Jun-ichi Eiki, Yasufumi Nagata, Mayumi Futamura, Kaori Sasaki-Yamamoto, Tomoharu Iino, Teruyuki Nishimura, Masato Chiba, Sumika Ohyama, Riki Yoshida-Yoshimioto, Kenji Fujii, Hideka Hosaka, Hiroko Goto-Shimazaki, Akito Kadotani, Tomoyuki Ohe, Songnian Lin, Ronald B. Langdon and Joel P. Berger
Molecular Pharmacology December 1, 2011, 80 (6) 1156-1165; DOI: https://doi.org/10.1124/mol.111.074401
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