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Research ArticlePerspective

How Can 1 + 1 = 3? β2-Adrenergic and Glucocorticoid Receptor Agonist Synergism in Obstructive Airway Diseases

Martina Schmidt and Martin C. Michel
Molecular Pharmacology December 2011, 80 (6) 955-958; DOI: https://doi.org/10.1124/mol.111.075481
Martina Schmidt
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Martin C. Michel
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Abstract

For a long time it was believed that β2-adrenergic receptor agonists used in the treatment of obstructive airway diseases worked primarily on airway smooth muscle cells, causing relaxation, whereas glucocorticoids primarily improved airway function via their anti-inflammatory action, indicating that their clinical synergism occurred at the organism rather than the cellular level. However, it is now becoming clear that both drug classes can affect airway function at multiple levels, including an integrated effect on several cell types. This article summarizes data on the molecular interaction between the two receptor systems, particularly with relevance to phenomena of β2-adrenergic receptor desensitization and glucocorticoid insensitivity in the airways. These molecular interactions may contribute to the observed clinical synergism between both drug classes in the treatment of obstructive airway diseases.

Footnotes

  • Article, publication date, and citation information can be found at http://molpharm.aspetjournals.org.

    doi:10.1124/mol.111.075481.

  • Please see the related article on page 1128.

  • ABBREVIATIONS:

    B2AR
    β2-adrenergic receptor
    LABA
    long-acting B2AR agonist
    MAPK
    mitogen-activated protein kinase
    MKP-1
    mitogen-activated protein kinase phosphatase-1
    C/EBPα
    CCAAT/enhancer binding protein α
    NF-κB
    nuclear factor-κB.

  • Received September 2, 2011.
  • Accepted September 13, 2011.
  • Copyright © 2011 The American Society for Pharmacology and Experimental Therapeutics
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Molecular Pharmacology: 80 (6)
Molecular Pharmacology
Vol. 80, Issue 6
1 Dec 2011
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Research ArticlePerspective

β2-Adrenergic and Glucocorticoid Receptor Agonist Synergism

Martina Schmidt and Martin C. Michel
Molecular Pharmacology December 1, 2011, 80 (6) 955-958; DOI: https://doi.org/10.1124/mol.111.075481

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Research ArticlePerspective

β2-Adrenergic and Glucocorticoid Receptor Agonist Synergism

Martina Schmidt and Martin C. Michel
Molecular Pharmacology December 1, 2011, 80 (6) 955-958; DOI: https://doi.org/10.1124/mol.111.075481
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