Table of Contents

Articles

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  Functional Impact of Allosteric Agonist Activity of Selective Positive Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5 in Regulating Central Nervous System Function

  Meredith J. Noetzel, Jerri M. Rook, Paige N. Vinson, Hyekyung P. Cho, Emily Days, Y. Zhou, Alice L. Rodriguez, Hilde Lavreysen, Shaun R. Stauffer, Colleen M. Niswender, Zixiu Xiang, J. Scott Daniels, Carrie K. Jones, Craig W. Lindsley, C. David Weaver and P. Jeffrey Conn

  Molecular Pharmacology February 2012, 81 (2) 120-133; DOI: https://doi.org/10.1124/mol.111.075184
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  Substrate- and pH-Specific Antifolate Transport Mediated by Organic Anion-Transporting Polypeptide 2B1 (OATP2B1-SLCO2B1)

  Michele Visentin, Min-Hwang Chang, Michael F. Romero, Rongbao Zhao and I. David Goldman

  Molecular Pharmacology February 2012, 81 (2) 134-142; DOI: https://doi.org/10.1124/mol.111.074823
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  Uterine Smooth Muscle S-Nitrosylproteome in Pregnancy

  Craig Ulrich, David R. Quillici, Kathleen Schegg, Rebekah Woolsey, Akira Nordmeier and Iain L. O. Buxton

  Molecular Pharmacology February 2012, 81 (2) 143-153; DOI: https://doi.org/10.1124/mol.111.075804
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  δ-Opioid Receptors Stimulate the Metabolic Sensor AMP-Activated Protein Kinase through Coincident Signaling with G_q/11-Coupled Receptors

  Maria C. Olianas, Simona Dedoni, Alessandra Olianas and Pierluigi Onali

  Molecular Pharmacology February 2012, 81 (2) 154-165; DOI: https://doi.org/10.1124/mol.111.075267
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  S1P₁ Receptor Modulation with Cyclical Recovery from Lymphopenia Ameliorates Mouse Model of Multiple Sclerosis

  Pedro J. Gonzalez-Cabrera, Stuart M. Cahalan, Nhan Nguyen, Gor Sarkisyan, Nora B. Leaf, Michael D. Cameron, Tomoyuki Kago and Hugh Rosen

  Molecular Pharmacology February 2012, 81 (2) 166-174; DOI: https://doi.org/10.1124/mol.111.076109
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  α7β2 Nicotinic Acetylcholine Receptors Assemble, Function, and Are Activated Primarily via Their α7-α7 Interfaces

  Teresa A. Murray, Daniel Bertrand, Roger L. Papke, Andrew A. George, Rigo Pantoja, Rahul Srinivasan, Qiang Liu, Jie Wu, Paul Whiteaker, Henry A. Lester and Ronald J. Lukas

  Molecular Pharmacology February 2012, 81 (2) 175-188; DOI: https://doi.org/10.1124/mol.111.074088
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  The Apparent Voltage Dependence of GABA_A Receptor Activation and Modulation Is Inversely Related to Channel Open Probability

  Kate K. O'Toole and Andrew Jenkins

  Molecular Pharmacology February 2012, 81 (2) 189-197; DOI: https://doi.org/10.1124/mol.111.074476
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  Molecular Determinants of Pentamidine-Induced hERG Trafficking Inhibition

  Adrienne T. Dennis, Lu Wang, Hanlin Wan, Drew Nassal, Isabelle Deschenes and Eckhard Ficker

  Molecular Pharmacology February 2012, 81 (2) 198-209; DOI: https://doi.org/10.1124/mol.111.075135
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  Evidence for a Common Pharmacological Interaction Site on K_Ca2 Channels Providing Both Selective Activation and Selective Inhibition of the Human K_Ca2.1 Subtype

  Charlotte Hougaard, Sofia Hammami, Birgitte L. Eriksen, Ulrik S. Sørensen, Marianne L. Jensen, Dorte Strøbæk and Palle Christophersen

  Molecular Pharmacology February 2012, 81 (2) 210-219; DOI: https://doi.org/10.1124/mol.111.074252
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  Characterization of Multidrug Resistance 1a/P-Glycoprotein Knockout Rats Generated by Zinc Finger Nucleases

  Xiaoyan Chu, Zuo Zhang, Jocelyn Yabut, Sarah Horwitz, John Levorse, Xiang-qing Li, Lei Zhu, Harmony Lederman, Rachel Ortiga, John Strauss, Xiaofang Li, Karen A. Owens, Jasminka Dragovic, Thomas Vogt, Raymond Evers and Myung K. Shin

  Molecular Pharmacology February 2012, 81 (2) 220-227; DOI: https://doi.org/10.1124/mol.111.074179
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  Cancer-Preventive Rexinoid Modulates Neutral Lipid Contents of Mammary Epithelial Cells through a Peroxisome Proliferator-Activated Receptor γ-Dependent Mechanism

  Iván P. Uray, Jennifer M. Rodenberg, Reid P. Bissonnette, Powel H. Brown and Michael A. Mancini

  Molecular Pharmacology February 2012, 81 (2) 228-238; DOI: https://doi.org/10.1124/mol.111.072967
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  Specificity Determinants of Allosteric Modulation in the Neuronal Nicotinic Acetylcholine Receptor: a Fine Line between Inhibition and Potentiation

  Laura C. Cesa, Colin A. Higgins, Steven R. Sando, Dennis W. Kuo and Mark M. Levandoski

  Molecular Pharmacology February 2012, 81 (2) 239-249; DOI: https://doi.org/10.1124/mol.111.076059
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  Functional Selectivity in CB₂ Cannabinoid Receptor Signaling and Regulation: Implications for the Therapeutic Potential of CB₂ Ligands

  Brady K. Atwood, James Wager-Miller, Christopher Haskins, Alex Straiker and Ken Mackie

  Molecular Pharmacology February 2012, 81 (2) 250-263; DOI: https://doi.org/10.1124/mol.111.074013
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  Allosteric Interactions between δ and κ Opioid Receptors in Peripheral Sensory Neurons

  Kelly A. Berg, Matthew P. Rowan, Achla Gupta, Teresa A. Sanchez, Michelle Silva, Ivone Gomes, Blaine A. McGuire, Philip S. Portoghese, Kenneth M. Hargreaves, Lakshmi A. Devi and William P. Clarke

  Molecular Pharmacology February 2012, 81 (2) 264-272; DOI: https://doi.org/10.1124/mol.111.072702
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  Characterization of the Role of ABCG2 as a Bile Acid Transporter in Liver and Placenta

  Alba G. Blazquez, Oscar Briz, Marta R. Romero, Ruben Rosales, Maria J. Monte, Javier Vaquero, Rocio I. R. Macias, Doris Cassio and Jose J. G. Marin

  Molecular Pharmacology February 2012, 81 (2) 273-283; DOI: https://doi.org/10.1124/mol.111.075143