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Molecular Pharmacology

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Research ArticleArticle

Functional Impact of Allosteric Agonist Activity of Selective Positive Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5 in Regulating Central Nervous System Function

Meredith J. Noetzel, Jerri M. Rook, Paige N. Vinson, Hyekyung P. Cho, Emily Days, Y. Zhou, Alice L. Rodriguez, Hilde Lavreysen, Shaun R. Stauffer, Colleen M. Niswender, Zixiu Xiang, J. Scott Daniels, Carrie K. Jones, Craig W. Lindsley, C. David Weaver and P. Jeffrey Conn
Molecular Pharmacology February 2012, 81 (2) 120-133; DOI: https://doi.org/10.1124/mol.111.075184
Meredith J. Noetzel
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Jerri M. Rook
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Paige N. Vinson
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Hyekyung P. Cho
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Emily Days
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Y. Zhou
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Alice L. Rodriguez
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Hilde Lavreysen
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Shaun R. Stauffer
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Colleen M. Niswender
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Zixiu Xiang
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J. Scott Daniels
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Carrie K. Jones
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Craig W. Lindsley
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C. David Weaver
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Article Information

vol. 81 no. 2 120-133
DOI 
https://doi.org/10.1124/mol.111.075184
PubMed 
22021324

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received August 8, 2011
  • Accepted October 20, 2011
  • Published online January 17, 2012.

Article Versions

  • Earlier version (October 21, 2011 - 08:10).
  • Earlier version (November 10, 2011 - 09:50).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2012 The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Meredith J. Noetzel,
  2. Jerri M. Rook,
  3. Paige N. Vinson,
  4. Hyekyung P. Cho,
  5. Emily Days,
  6. Y. Zhou,
  7. Alice L. Rodriguez,
  8. Hilde Lavreysen,
  9. Shaun R. Stauffer,
  10. Colleen M. Niswender,
  11. Zixiu Xiang,
  12. J. Scott Daniels,
  13. Carrie K. Jones,
  14. Craig W. Lindsley,
  15. C. David Weaver and
  16. P. Jeffrey Conn
  1. Department of Pharmacology and Vanderbilt Center for Neuroscience Drug Discovery (M.J.N., J.M.R., P.N.V., H.P.C., E.D., Y.Z., A.L.R., S.R.S., C.M.N., Z.X., J.S.D., C.K.J., C.W.L., C.D.W., P.J.C.), Department of Chemistry (H.P.C., S.R.S., C.W.L.), and Vanderbilt Institute of Chemical Biology (E.D., C.D.W.), Vanderbilt University Medical Center, Nashville, Tennessee; and Neuroscience, Janssen Research and Development, a division of Janssen Pharmaceutica NV, Beerse, Belgium (H.L.)
  1. Address correspondence to:
    Dr. P. Jeffrey Conn, Vanderbilt Center for Neuroscience Drug Discovery, Department of Pharmacology, Vanderbilt University Medical Center, 1215 Light Hall, Nashville, TN 37232-0697. E-mail: jeff.conn{at}vanderbilt.edu
  1. This work was previously presented in part in the following publication: Noetzel MJ, Cho HP, Days E, Zhou Y, Rodriguez AL, Steckler T, Lavreysen H, Stauffer SR, Niswender CM, Lindsley CW, Weaver CD, and Conn PJ (2010) Receptor expression level influences the effect of allosteric modulators at metabotropic glutamate receptor 5, in Proceedings of the Neuroscience 2010; 2010 Nov 10–17; San Diego, CA. Society for Neuroscience, Washington, DC.

  1. M.N. and J.R. contributed equally to this work.

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Molecular Pharmacology: 81 (2)
Molecular Pharmacology
Vol. 81, Issue 2
1 Feb 2012
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Research ArticleArticle

Functional Effects of mGlu5 PAMs and Ago-PAMs

Meredith J. Noetzel, Jerri M. Rook, Paige N. Vinson, Hyekyung P. Cho, Emily Days, Y. Zhou, Alice L. Rodriguez, Hilde Lavreysen, Shaun R. Stauffer, Colleen M. Niswender, Zixiu Xiang, J. Scott Daniels, Carrie K. Jones, Craig W. Lindsley, C. David Weaver and P. Jeffrey Conn
Molecular Pharmacology February 1, 2012, 81 (2) 120-133; DOI: https://doi.org/10.1124/mol.111.075184

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Research ArticleArticle

Functional Effects of mGlu5 PAMs and Ago-PAMs

Meredith J. Noetzel, Jerri M. Rook, Paige N. Vinson, Hyekyung P. Cho, Emily Days, Y. Zhou, Alice L. Rodriguez, Hilde Lavreysen, Shaun R. Stauffer, Colleen M. Niswender, Zixiu Xiang, J. Scott Daniels, Carrie K. Jones, Craig W. Lindsley, C. David Weaver and P. Jeffrey Conn
Molecular Pharmacology February 1, 2012, 81 (2) 120-133; DOI: https://doi.org/10.1124/mol.111.075184
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