Cover Caption

About the cover: A cytoplasmic view (top left) of the superimposed KcsA-based (red) and NavAb-based (green) models of Nav1. For clarity, S5 helices not shown. Tetracaine is shown as rods with red oxygens, blue nitrogens, and orange carbons. A side view (top right) has two repeats removed for clarity and the selectivity-filter residues (DEKA, Asp-Glu-Lys-Ala) shown as sticks. Orthogonal side views (bottom) of the NavAb-based model of Nav1.4 with the local anesthetic-sensing residue Tyr⁴ⁱ²² shown as sticks. Some residues that control the hydrophobic access pathway to the closed channels are space-filled. See article by Tikhonov and Zhorov on page 97 of this issue.