Table of Contents

Articles

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  Localization of a Site of Action for Benzofuroindole-Induced Potentiation of BK_Ca Channels

  Byoung-Cheol Lee, Hyun-Ho Lim, Songmi Kim, Hyung-Seop Youn, Yuno Lee, Yong-Chul Kim, Soo Hyun Eom, Keun Woo Lee and Chul-Seung Park

  Molecular Pharmacology August 2012, 82 (2) 143-155; DOI: https://doi.org/10.1124/mol.112.078097
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  OX₁ Orexin/Hypocretin Receptor Signaling through Arachidonic Acid and Endocannabinoid Release

  Pauli M. Turunen, Maria H. Jäntti and Jyrki P. Kukkonen

  Molecular Pharmacology August 2012, 82 (2) 156-167; DOI: https://doi.org/10.1124/mol.112.078063
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  Wnt/β-Catenin Signaling Mediates the Antitumor Activity of Magnolol in Colorectal Cancer Cells

  You-Jin Kang, Hyen Joo Park, Hwa-Jin Chung, Hye-Young Min, Eun Jung Park, Min Ai Lee, Yoonho Shin and Sang Kook Lee

  Molecular Pharmacology August 2012, 82 (2) 168-177; DOI: https://doi.org/10.1124/mol.112.078535
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  Endomorphin-2: A Biased Agonist at the μ-Opioid Receptor

  Guadalupe Rivero, Javier Llorente, Jamie McPherson, Alex Cooke, Stuart J. Mundell, Craig A. McArdle, Elizabeth M. Rosethorne, Steven J. Charlton, Cornelius Krasel, Christopher P. Bailey, Graeme Henderson and Eamonn Kelly

  Molecular Pharmacology August 2012, 82 (2) 178-188; DOI: https://doi.org/10.1124/mol.112.078659
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  DC120, a Novel and Potent Inhibitor of AKT Kinase, Induces Tumor Cell Apoptosis and Suppresses Tumor Growth

  Rong Deng, Fen Yang, Shao-hua Chang, Jun Tang, Juan Qin, Gong-Kan Feng, Ke Ding and Xiao-Feng Zhu

  Molecular Pharmacology August 2012, 82 (2) 189-198; DOI: https://doi.org/10.1124/mol.111.077271
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  The Synaptic Vesicle Glycoprotein 2A Ligand Levetiracetam Inhibits Presynaptic Ca²⁺ Channels through an Intracellular Pathway

  Christian Vogl, Sumiko Mochida, Christian Wolff, Benjamin J. Whalley and Gary J. Stephens

  Molecular Pharmacology August 2012, 82 (2) 199-208; DOI: https://doi.org/10.1124/mol.111.076687
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  Augmentation of Reduced Folate Carrier-Mediated Folate/Antifolate Transport through an Antiport Mechanism with 5-Aminoimidazole-4-Carboxamide Riboside Monophosphate

  Michele Visentin, Rongbao Zhao and I. David Goldman

  Molecular Pharmacology August 2012, 82 (2) 209-216; DOI: https://doi.org/10.1124/mol.112.078642
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  The Guanine Nucleotide Exchange Factor Vav2 Is a Negative Regulator of Parathyroid Hormone Receptor/G_q Signaling

  Alexander Emami-Nemini, Antje Gohla, Henning Urlaub, Martin J. Lohse and Christoph Klenk

  Molecular Pharmacology August 2012, 82 (2) 217-225; DOI: https://doi.org/10.1124/mol.112.078824
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  γ-Hydroxybutyrate (GHB)-Induced Respiratory Depression: Combined Receptor-Transporter Inhibition Therapy for Treatment in GHB Overdose

  Bridget L. Morse, Nisha Vijay and Marilyn E. Morris

  Molecular Pharmacology August 2012, 82 (2) 226-235; DOI: https://doi.org/10.1124/mol.112.078154
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  Comparison of the Activation Kinetics of the M₃ Acetylcholine Receptor and a Constitutively Active Mutant Receptor in Living Cells

  Carsten Hoffmann, Susanne Nuber, Ulrike Zabel, Nicole Ziegler, Christiane Winkler, Peter Hein, Catherine H. Berlot, Moritz Bünemann and Martin J. Lohse

  Molecular Pharmacology August 2012, 82 (2) 236-245; DOI: https://doi.org/10.1124/mol.112.077578
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  Cholesterol-Lowering Drugs Inhibit Lectin-Like Oxidized Low-Density Lipoprotein-1 Receptor Function by Membrane Raft Disruption

  Sara Matarazzo, Maria Chiara Quitadamo, Ruggiero Mango, Sarah Ciccone, Giuseppe Novelli and Silvia Biocca

  Molecular Pharmacology August 2012, 82 (2) 246-254; DOI: https://doi.org/10.1124/mol.112.078915
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  Agonist-Specific Conformational Changes in the α1-γ2 Subunit Interface of the GABA_A Receptor

  Megan M. Eaton, You Bin Lim, John Bracamontes, Joe Henry Steinbach and Gustav Akk

  Molecular Pharmacology August 2012, 82 (2) 255-263; DOI: https://doi.org/10.1124/mol.112.077875
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  Role of Activating Transcription Factor-4 in 24-Hour Rhythm of Serotonin Transporter Expression in the Mouse Midbrain

  Kentarou Ushijima, Satoru Koyanagi, Yuuki Sato, Takamitsu Ogata, Naoya Matsunaga, Akio Fujimura and Shigehiro Ohdo

  Molecular Pharmacology August 2012, 82 (2) 264-270; DOI: https://doi.org/10.1124/mol.112.079079
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  α2δ Ligands Act as Positive Modulators of Adult Hippocampal Neurogenesis and Prevent Depression-Like Behavior Induced by Chronic Restraint Stress

  Maria Maddalena Valente, Valeria Bortolotto, Bruna Cuccurazzu, Federica Ubezio, Vasco Meneghini, Maria Teresa Francese, Pier Luigi Canonico and Mariagrazia Grilli

  Molecular Pharmacology August 2012, 82 (2) 271-280; DOI: https://doi.org/10.1124/mol.112.077636
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  Allosteric Modulation of Endogenous Metabolites as an Avenue for Drug Discovery

  Denise Wootten, Emilia E. Savage, Celine Valant, Lauren T. May, Kyle W. Sloop, James Ficorilli, Aaron D. Showalter, Francis S. Willard, Arthur Christopoulos and Patrick M. Sexton

  Molecular Pharmacology August 2012, 82 (2) 281-290; DOI: https://doi.org/10.1124/mol.112.079319
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  Ligand Bias at Metabotropic Glutamate 1a Receptors: Molecular Determinants That Distinguish β-Arrestin-Mediated from G Protein-Mediated Signaling

  Andrew C. Emery, John O. DiRaddo, Eric Miller, Hannah A. Hathaway, Sergey Pshenichkin, Guy Rodrigue Takoudjou, Ewa Grajkowska, Robert P. Yasuda, Barry B. Wolfe and Jarda T. Wroblewski

  Molecular Pharmacology August 2012, 82 (2) 291-301; DOI: https://doi.org/10.1124/mol.112.078444
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  Formation of the Thiol Conjugates and Active Metabolite of Clopidogrel by Human Liver Microsomes

  Haoming Zhang, Wei C. Lau and Paul F. Hollenberg

  Molecular Pharmacology August 2012, 82 (2) 302-309; DOI: https://doi.org/10.1124/mol.112.079061
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  Telomere and Microtubule Targeting in Treatment-Sensitive and Treatment-Resistant Human Prostate Cancer Cells

  Bin Zhang, Silke Suer, Ferenc Livak, Samusi Adediran, Arvind Vemula, Mohammad Afnan Khan, Yi Ning and Arif Hussain

  Molecular Pharmacology August 2012, 82 (2) 310-321; DOI: https://doi.org/10.1124/mol.111.076752
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  Poly(ADP-ribose) Polymerase 1 Modulates the Lethality of CHK1 Inhibitors in Mammary Tumors

  Yong Tang, Hossein A. Hamed, Andrew Poklepovic, Yun Dai, Steven Grant and Paul Dent

  Molecular Pharmacology August 2012, 82 (2) 322-332; DOI: https://doi.org/10.1124/mol.112.078907
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  Differential Modulation of Drug-Induced Structural and Functional Plasticity of Dendritic Spines

  Eric C. Miller, Lei Zhang, Benjamin W. Dummer, Desmond R. Cariveau, Horace Loh, Ping-Yee Law and Dezhi Liao

  Molecular Pharmacology August 2012, 82 (2) 333-343; DOI: https://doi.org/10.1124/mol.112.078162
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  Mapping the Binding of GluN2B-Selective N-Methyl-d-aspartate Receptor Negative Allosteric Modulators

  Pieter B. Burger, Hongjie Yuan, Erkan Karakas, Matthew Geballe, Hiro Furukawa, Dennis C. Liotta, James P. Snyder and Stephen F. Traynelis

  Molecular Pharmacology August 2012, 82 (2) 344-359; DOI: https://doi.org/10.1124/mol.112.078568