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Research ArticleArticle

Allosteric Modulation of Endogenous Metabolites as an Avenue for Drug Discovery

Denise Wootten, Emilia E. Savage, Celine Valant, Lauren T. May, Kyle W. Sloop, James Ficorilli, Aaron D. Showalter, Francis S. Willard, Arthur Christopoulos and Patrick M. Sexton
Molecular Pharmacology August 2012, 82 (2) 281-290; DOI: https://doi.org/10.1124/mol.112.079319
Denise Wootten
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Emilia E. Savage
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Celine Valant
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Lauren T. May
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Kyle W. Sloop
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James Ficorilli
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Aaron D. Showalter
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Francis S. Willard
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Arthur Christopoulos
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Patrick M. Sexton
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Article Information

vol. 82 no. 2 281-290
DOI 
https://doi.org/10.1124/mol.112.079319
PubMed 
22576254

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received April 13, 2012
  • Accepted May 10, 2012
  • Published online July 16, 2012.

Article Versions

  • Earlier version (May 10, 2012 - 07:57).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2012 The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Denise Wootten,
  2. Emilia E. Savage,
  3. Celine Valant,
  4. Lauren T. May,
  5. Kyle W. Sloop,
  6. James Ficorilli,
  7. Aaron D. Showalter,
  8. Francis S. Willard,
  9. Arthur Christopoulos and
  10. Patrick M. Sexton
  1. Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences and Department of Pharmacology, Monash University, Parkville, Victoria, Australia (D.W., E.E.S., C.V., L.T.M., A.C., P.M.S.); and Endocrine Discovery (K.W.S., J.F., A.D.S.) and Translational Science and Technologies (F.S.W.), Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana
  1. Address correspondence to:
    Prof. Patrick M. Sexton, Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia. E-mail: patrick.sexton{at}monash.edu
  1. D.W. and E.E.S. contributed equally to this work.

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Molecular Pharmacology: 82 (2)
Molecular Pharmacology
Vol. 82, Issue 2
1 Aug 2012
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Research ArticleArticle

Allosteric Modulation of Metabolites at GPCRs

Denise Wootten, Emilia E. Savage, Celine Valant, Lauren T. May, Kyle W. Sloop, James Ficorilli, Aaron D. Showalter, Francis S. Willard, Arthur Christopoulos and Patrick M. Sexton
Molecular Pharmacology August 1, 2012, 82 (2) 281-290; DOI: https://doi.org/10.1124/mol.112.079319

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Research ArticleArticle

Allosteric Modulation of Metabolites at GPCRs

Denise Wootten, Emilia E. Savage, Celine Valant, Lauren T. May, Kyle W. Sloop, James Ficorilli, Aaron D. Showalter, Francis S. Willard, Arthur Christopoulos and Patrick M. Sexton
Molecular Pharmacology August 1, 2012, 82 (2) 281-290; DOI: https://doi.org/10.1124/mol.112.079319
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