Table of Contents

Articles

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  Increasing Human Th17 Differentiation through Activation of Orphan Nuclear Receptor Retinoid Acid-Related Orphan Receptor γ (RORγ) by a Class of Aryl Amide Compounds

  Wei Zhang, Jing Zhang, Leiping Fang, Ling Zhou, Shuai Wang, Zhijun Xiang, Yuan Li, Bruce Wisely, Guifeng Zhang, Gang An, Yonghui Wang, Stewart Leung and Zhong Zhong

  Molecular Pharmacology October 2012, 82 (4) 583-590; DOI: https://doi.org/10.1124/mol.112.078667
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  Functional Loss of the Reduced Folate Carrier Enhances the Antitumor Activities of Novel Antifolates with Selective Uptake by the Proton-Coupled Folate Transporter

  Sita Kugel Desmoulin, Lei Wang, Lisa Polin, Kathryn White, Juiwanna Kushner, Mark Stout, Zhanjun Hou, Christina Cherian, Aleem Gangjee and Larry H. Matherly

  Molecular Pharmacology October 2012, 82 (4) 591-600; DOI: https://doi.org/10.1124/mol.112.079004
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  Activator Protein-1 Regulation of Murine Aldehyde Dehydrogenase 1a1

  N. L. Makia, I. Amunom, K. C. Falkner, D. J. Conklin, S. Surapureddi, J. A. Goldstein and R. A. Prough

  Molecular Pharmacology October 2012, 82 (4) 601-613; DOI: https://doi.org/10.1124/mol.112.078147
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  Anacardic Acid Inhibits the Catalytic Activity of Matrix Metalloproteinase-2 and Matrix Metalloproteinase-9

  Athira Omanakuttan, Jyotsna Nambiar, Rodney M. Harris, Chinchu Bose, Nanjan Pandurangan, Rebu K. Varghese, Geetha B. Kumar, John A. Tainer, Asoke Banerji, J. Jefferson P. Perry and Bipin G. Nair

  Molecular Pharmacology October 2012, 82 (4) 614-622; DOI: https://doi.org/10.1124/mol.112.079020
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  RNA Aptamer-Based Functional Ligands of the Neurotrophin Receptor, TrkB

  Yang Zhong Huang, Frank J. Hernandez, Bin Gu, Katie R. Stockdale, Kishore Nanapaneni, Todd E. Scheetz, Mark A. Behlke, Andrew S. Peek, Thomas Bair, Paloma H. Giangrande and James O. McNamara

  Molecular Pharmacology October 2012, 82 (4) 623-635; DOI: https://doi.org/10.1124/mol.112.078220
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  P-Glycoprotein, Multidrug-Resistance Associated Protein 2, Cyp3a, and Carboxylesterase Affect the Oral Availability and Metabolism of Vinorelbine

  Jurjen S. Lagas, Carola W. N. Damen, Robert A. B. van Waterschoot, Dilek Iusuf, Jos H. Beijnen and Alfred H. Schinkel

  Molecular Pharmacology October 2012, 82 (4) 636-644; DOI: https://doi.org/10.1124/mol.111.077099
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  Discovery of Regulators of Receptor Internalization with High-Throughput Flow Cytometry

  Yang Wu, Phillip H. Tapia, Gregory W. Fisher, Peter C. Simons, J. Jacob Strouse, Terry Foutz, Alan S. Waggoner, Jonathan Jarvik and Larry A. Sklar

  Molecular Pharmacology October 2012, 82 (4) 645-657; DOI: https://doi.org/10.1124/mol.112.079897
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  Block of Human Ca_V3 Channels by the Diuretic Amiloride

  Osbaldo Lopez-Charcas, Manuel Rivera and Juan C. Gomora

  Molecular Pharmacology October 2012, 82 (4) 658-667; DOI: https://doi.org/10.1124/mol.112.078923
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  D₂-Dopaminergic Receptor-Linked Pathways: Critical Regulators of CYP3A, CYP2C, and CYP2D

  Evangelos P. Daskalopoulos, Matti A. Lang, Marios Marselos, Foteini Malliou and Maria Konstandi

  Molecular Pharmacology October 2012, 82 (4) 668-678; DOI: https://doi.org/10.1124/mol.112.078709
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  CYP4V2 in Bietti's Crystalline Dystrophy: Ocular Localization, Metabolism of ω-3-Polyunsaturated Fatty Acids, and Functional Deficit of the p.H331P Variant

  Mariko Nakano, Edward J. Kelly, Constanze Wiek, Helmut Hanenberg and Allan E. Rettie

  Molecular Pharmacology October 2012, 82 (4) 679-686; DOI: https://doi.org/10.1124/mol.112.080085
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  Synthesis of Selective Agonists for the α7 Nicotinic Acetylcholine Receptor with In Situ Click-Chemistry on Acetylcholine-Binding Protein Templates

  John G. Yamauchi, Kimberly Gomez, Neil Grimster, Mikael Dufouil, Ákos Nemecz, Joseph R. Fotsing, Kwok-Yiu Ho, Todd T. Talley, K. Barry Sharpless, Valery V. Fokin and Palmer Taylor

  Molecular Pharmacology October 2012, 82 (4) 687-699; DOI: https://doi.org/10.1124/mol.112.080291
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  Therapeutic Potential of Nitric Oxide-Modified Drugs in Colon Cancer Cells

  Marija Mojic, Sanja Mijatovic, Danijela Maksimovic-Ivanic, Djordje Miljkovic, Stanislava Stosic-Grujicic, Marija Stankovic, Katia Mangano, Salvatore Travali, Marco Donia, Paolo Fagone, Mai-Britt Zocca, Yousef Al-Abed, James A. McCubrey and Ferdinando Nicoletti

  Molecular Pharmacology October 2012, 82 (4) 700-710; DOI: https://doi.org/10.1124/mol.112.077842
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  Efficient Binding of 4/7 α-Conotoxins to Nicotinic α4β2 Receptors Is Prevented by Arg185 and Pro195 in the α4 Subunit

  Mirko Beissner, Sébastien Dutertre, Rudolf Schemm, Timm Danker, Annett Sporning, Helmut Grubmüller and Annette Nicke

  Molecular Pharmacology October 2012, 82 (4) 711-718; DOI: https://doi.org/10.1124/mol.112.078683
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  Regulation of Sphingomyelin Phosphodiesterase Acid-Like 3A Gene (SMPDL3A) by Liver X Receptors

  Paul B. Noto, Yuri Bukhtiyarov, Meng Shi, Brian M. McKeever, Gerard M. McGeehan and Deepak S. Lala

  Molecular Pharmacology October 2012, 82 (4) 719-727; DOI: https://doi.org/10.1124/mol.112.078865
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  Sustained Activation of N-Methyl-d-Aspartate Receptors in Podoctyes Leads to Oxidative Stress, Mobilization of Transient Receptor Potential Canonical 6 Channels, Nuclear Factor of Activated T Cells Activation, and Apoptotic Cell Death

  Eun Young Kim, Marc Anderson and Stuart E. Dryer

  Molecular Pharmacology October 2012, 82 (4) 728-737; DOI: https://doi.org/10.1124/mol.112.079376
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  A Role for Kalirin in the Response of Rat Medium Spiny Neurons to Cocaine

  Xin-Ming Ma, Jian-ping Huang, Xiaonan Xin, Yan Yan, Richard E. Mains and Betty A. Eipper

  Molecular Pharmacology October 2012, 82 (4) 738-745; DOI: https://doi.org/10.1124/mol.112.080044
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  Intrinsically Low Open Probability of α7 Nicotinic Acetylcholine Receptors Can Be Overcome by Positive Allosteric Modulation and Serum Factors Leading to the Generation of Excitotoxic Currents at Physiological Temperatures

  Dustin K. Williams, Can Peng, Matthew R. Kimbrell and Roger L. Papke

  Molecular Pharmacology October 2012, 82 (4) 746-759; DOI: https://doi.org/10.1124/mol.112.080317
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  Activation of Trimeric P2X2 Receptors by Fewer than Three ATP Molecules

  Olga Stelmashenko, Ulyana Lalo, Yue Yang, Laricia Bragg, R. Alan North and Vincent Compan

  Molecular Pharmacology October 2012, 82 (4) 760-766; DOI: https://doi.org/10.1124/mol.112.080903
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  Identification of DNA Repair Pathways That Affect the Survival of Ovarian Cancer Cells Treated with a Poly(ADP-Ribose) Polymerase Inhibitor in a Novel Drug Combination

  Amelia M. Huehls, Jill M. Wagner, Catherine J. Huntoon and Larry M. Karnitz

  Molecular Pharmacology October 2012, 82 (4) 767-776; DOI: https://doi.org/10.1124/mol.112.080614