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Molecular Pharmacology

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Research ArticleArticle

Increasing Human Th17 Differentiation through Activation of Orphan Nuclear Receptor Retinoid Acid-Related Orphan Receptor γ (RORγ) by a Class of Aryl Amide Compounds

Wei Zhang, Jing Zhang, Leiping Fang, Ling Zhou, Shuai Wang, Zhijun Xiang, Yuan Li, Bruce Wisely, Guifeng Zhang, Gang An, Yonghui Wang, Stewart Leung and Zhong Zhong
Molecular Pharmacology October 2012, 82 (4) 583-590; DOI: https://doi.org/10.1124/mol.112.078667
Wei Zhang
Discovery Technology (W.Z., J.Z., L.F., S.W., Y.L., G.Z., G.A., Z.Z.), Medicinal Chemistry (Y.W.), and Neuroinflammation Discovery Performance Unit (W.Z., J.Z., L.F., L.Z., Z.X., Y.W., S.L.), GlaxoSmithKline R&D Center, Shanghai, China; and Biological Reagents and Assay Development, Platform Technology Science, GlaxoSmithKline, Research Triangle Park, North Carolina (B.W.)
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Jing Zhang
Discovery Technology (W.Z., J.Z., L.F., S.W., Y.L., G.Z., G.A., Z.Z.), Medicinal Chemistry (Y.W.), and Neuroinflammation Discovery Performance Unit (W.Z., J.Z., L.F., L.Z., Z.X., Y.W., S.L.), GlaxoSmithKline R&D Center, Shanghai, China; and Biological Reagents and Assay Development, Platform Technology Science, GlaxoSmithKline, Research Triangle Park, North Carolina (B.W.)
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Leiping Fang
Discovery Technology (W.Z., J.Z., L.F., S.W., Y.L., G.Z., G.A., Z.Z.), Medicinal Chemistry (Y.W.), and Neuroinflammation Discovery Performance Unit (W.Z., J.Z., L.F., L.Z., Z.X., Y.W., S.L.), GlaxoSmithKline R&D Center, Shanghai, China; and Biological Reagents and Assay Development, Platform Technology Science, GlaxoSmithKline, Research Triangle Park, North Carolina (B.W.)
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Ling Zhou
Discovery Technology (W.Z., J.Z., L.F., S.W., Y.L., G.Z., G.A., Z.Z.), Medicinal Chemistry (Y.W.), and Neuroinflammation Discovery Performance Unit (W.Z., J.Z., L.F., L.Z., Z.X., Y.W., S.L.), GlaxoSmithKline R&D Center, Shanghai, China; and Biological Reagents and Assay Development, Platform Technology Science, GlaxoSmithKline, Research Triangle Park, North Carolina (B.W.)
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Shuai Wang
Discovery Technology (W.Z., J.Z., L.F., S.W., Y.L., G.Z., G.A., Z.Z.), Medicinal Chemistry (Y.W.), and Neuroinflammation Discovery Performance Unit (W.Z., J.Z., L.F., L.Z., Z.X., Y.W., S.L.), GlaxoSmithKline R&D Center, Shanghai, China; and Biological Reagents and Assay Development, Platform Technology Science, GlaxoSmithKline, Research Triangle Park, North Carolina (B.W.)
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Zhijun Xiang
Discovery Technology (W.Z., J.Z., L.F., S.W., Y.L., G.Z., G.A., Z.Z.), Medicinal Chemistry (Y.W.), and Neuroinflammation Discovery Performance Unit (W.Z., J.Z., L.F., L.Z., Z.X., Y.W., S.L.), GlaxoSmithKline R&D Center, Shanghai, China; and Biological Reagents and Assay Development, Platform Technology Science, GlaxoSmithKline, Research Triangle Park, North Carolina (B.W.)
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Yuan Li
Discovery Technology (W.Z., J.Z., L.F., S.W., Y.L., G.Z., G.A., Z.Z.), Medicinal Chemistry (Y.W.), and Neuroinflammation Discovery Performance Unit (W.Z., J.Z., L.F., L.Z., Z.X., Y.W., S.L.), GlaxoSmithKline R&D Center, Shanghai, China; and Biological Reagents and Assay Development, Platform Technology Science, GlaxoSmithKline, Research Triangle Park, North Carolina (B.W.)
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Bruce Wisely
Discovery Technology (W.Z., J.Z., L.F., S.W., Y.L., G.Z., G.A., Z.Z.), Medicinal Chemistry (Y.W.), and Neuroinflammation Discovery Performance Unit (W.Z., J.Z., L.F., L.Z., Z.X., Y.W., S.L.), GlaxoSmithKline R&D Center, Shanghai, China; and Biological Reagents and Assay Development, Platform Technology Science, GlaxoSmithKline, Research Triangle Park, North Carolina (B.W.)
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Guifeng Zhang
Discovery Technology (W.Z., J.Z., L.F., S.W., Y.L., G.Z., G.A., Z.Z.), Medicinal Chemistry (Y.W.), and Neuroinflammation Discovery Performance Unit (W.Z., J.Z., L.F., L.Z., Z.X., Y.W., S.L.), GlaxoSmithKline R&D Center, Shanghai, China; and Biological Reagents and Assay Development, Platform Technology Science, GlaxoSmithKline, Research Triangle Park, North Carolina (B.W.)
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Gang An
Discovery Technology (W.Z., J.Z., L.F., S.W., Y.L., G.Z., G.A., Z.Z.), Medicinal Chemistry (Y.W.), and Neuroinflammation Discovery Performance Unit (W.Z., J.Z., L.F., L.Z., Z.X., Y.W., S.L.), GlaxoSmithKline R&D Center, Shanghai, China; and Biological Reagents and Assay Development, Platform Technology Science, GlaxoSmithKline, Research Triangle Park, North Carolina (B.W.)
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Yonghui Wang
Discovery Technology (W.Z., J.Z., L.F., S.W., Y.L., G.Z., G.A., Z.Z.), Medicinal Chemistry (Y.W.), and Neuroinflammation Discovery Performance Unit (W.Z., J.Z., L.F., L.Z., Z.X., Y.W., S.L.), GlaxoSmithKline R&D Center, Shanghai, China; and Biological Reagents and Assay Development, Platform Technology Science, GlaxoSmithKline, Research Triangle Park, North Carolina (B.W.)
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Stewart Leung
Discovery Technology (W.Z., J.Z., L.F., S.W., Y.L., G.Z., G.A., Z.Z.), Medicinal Chemistry (Y.W.), and Neuroinflammation Discovery Performance Unit (W.Z., J.Z., L.F., L.Z., Z.X., Y.W., S.L.), GlaxoSmithKline R&D Center, Shanghai, China; and Biological Reagents and Assay Development, Platform Technology Science, GlaxoSmithKline, Research Triangle Park, North Carolina (B.W.)
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Zhong Zhong
Discovery Technology (W.Z., J.Z., L.F., S.W., Y.L., G.Z., G.A., Z.Z.), Medicinal Chemistry (Y.W.), and Neuroinflammation Discovery Performance Unit (W.Z., J.Z., L.F., L.Z., Z.X., Y.W., S.L.), GlaxoSmithKline R&D Center, Shanghai, China; and Biological Reagents and Assay Development, Platform Technology Science, GlaxoSmithKline, Research Triangle Park, North Carolina (B.W.)
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Article Information

vol. 82 no. 4 583-590
DOI 
https://doi.org/10.1124/mol.112.078667
PubMed 
22700697

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received March 7, 2012
  • Accepted June 14, 2012
  • Published online September 26, 2012.

Article Versions

  • Earlier version (June 14, 2012 - 08:30).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2012 The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Wei Zhang,
  2. Jing Zhang,
  3. Leiping Fang,
  4. Ling Zhou,
  5. Shuai Wang,
  6. Zhijun Xiang,
  7. Yuan Li,
  8. Bruce Wisely,
  9. Guifeng Zhang,
  10. Gang An,
  11. Yonghui Wang,
  12. Stewart Leung, and
  13. Zhong Zhong
  1. Discovery Technology (W.Z., J.Z., L.F., S.W., Y.L., G.Z., G.A., Z.Z.), Medicinal Chemistry (Y.W.), and Neuroinflammation Discovery Performance Unit (W.Z., J.Z., L.F., L.Z., Z.X., Y.W., S.L.), GlaxoSmithKline R&D Center, Shanghai, China; and Biological Reagents and Assay Development, Platform Technology Science, GlaxoSmithKline, Research Triangle Park, North Carolina (B.W.)
  1. Address correspondence to:
    Wei Zhang, 898-3 Halei Road Zhangjiang Hi-tech Park, Pudong Shanghai, China 201203. E-mail: wei.3.zhang{at}gsk.com
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Molecular Pharmacology: 82 (4)
Molecular Pharmacology
Vol. 82, Issue 4
1 Oct 2012
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Research ArticleArticle

RORγ Activation by Potent Small-Molecule Compounds

Wei Zhang, Jing Zhang, Leiping Fang, Ling Zhou, Shuai Wang, Zhijun Xiang, Yuan Li, Bruce Wisely, Guifeng Zhang, Gang An, Yonghui Wang, Stewart Leung and Zhong Zhong
Molecular Pharmacology October 1, 2012, 82 (4) 583-590; DOI: https://doi.org/10.1124/mol.112.078667

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Research ArticleArticle

RORγ Activation by Potent Small-Molecule Compounds

Wei Zhang, Jing Zhang, Leiping Fang, Ling Zhou, Shuai Wang, Zhijun Xiang, Yuan Li, Bruce Wisely, Guifeng Zhang, Gang An, Yonghui Wang, Stewart Leung and Zhong Zhong
Molecular Pharmacology October 1, 2012, 82 (4) 583-590; DOI: https://doi.org/10.1124/mol.112.078667
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