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Molecular Pharmacology

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Research ArticleArticle

Functional Loss of the Reduced Folate Carrier Enhances the Antitumor Activities of Novel Antifolates with Selective Uptake by the Proton-Coupled Folate Transporter

Sita Kugel Desmoulin, Lei Wang, Lisa Polin, Kathryn White, Juiwanna Kushner, Mark Stout, Zhanjun Hou, Christina Cherian, Aleem Gangjee and Larry H. Matherly
Molecular Pharmacology October 2012, 82 (4) 591-600; DOI: https://doi.org/10.1124/mol.112.079004
Sita Kugel Desmoulin
Graduate Program in Cancer Biology (S.K.D., L.H.M.) and Departments of Oncology (S.K.D., L.P., K.W., J.K., Z.H., C.C., L.H.M.) and Pharmacology (L.H.M.), Wayne State University School of Medicine, Detroit, Michigan; Molecular Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Detroit, Michigan (L.P., Z.H., C.C., L.H.M.); Department of Pediatrics, Children's Hospital of Michigan, Detroit, Michigan (M.S.); and Division of Medicinal Chemistry, Graduate School of Pharmaceutical Science, Duquesne University, Pittsburgh, Pennsylvania (L.W., A.G.)
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Lei Wang
Graduate Program in Cancer Biology (S.K.D., L.H.M.) and Departments of Oncology (S.K.D., L.P., K.W., J.K., Z.H., C.C., L.H.M.) and Pharmacology (L.H.M.), Wayne State University School of Medicine, Detroit, Michigan; Molecular Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Detroit, Michigan (L.P., Z.H., C.C., L.H.M.); Department of Pediatrics, Children's Hospital of Michigan, Detroit, Michigan (M.S.); and Division of Medicinal Chemistry, Graduate School of Pharmaceutical Science, Duquesne University, Pittsburgh, Pennsylvania (L.W., A.G.)
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Lisa Polin
Graduate Program in Cancer Biology (S.K.D., L.H.M.) and Departments of Oncology (S.K.D., L.P., K.W., J.K., Z.H., C.C., L.H.M.) and Pharmacology (L.H.M.), Wayne State University School of Medicine, Detroit, Michigan; Molecular Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Detroit, Michigan (L.P., Z.H., C.C., L.H.M.); Department of Pediatrics, Children's Hospital of Michigan, Detroit, Michigan (M.S.); and Division of Medicinal Chemistry, Graduate School of Pharmaceutical Science, Duquesne University, Pittsburgh, Pennsylvania (L.W., A.G.)
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Kathryn White
Graduate Program in Cancer Biology (S.K.D., L.H.M.) and Departments of Oncology (S.K.D., L.P., K.W., J.K., Z.H., C.C., L.H.M.) and Pharmacology (L.H.M.), Wayne State University School of Medicine, Detroit, Michigan; Molecular Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Detroit, Michigan (L.P., Z.H., C.C., L.H.M.); Department of Pediatrics, Children's Hospital of Michigan, Detroit, Michigan (M.S.); and Division of Medicinal Chemistry, Graduate School of Pharmaceutical Science, Duquesne University, Pittsburgh, Pennsylvania (L.W., A.G.)
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Juiwanna Kushner
Graduate Program in Cancer Biology (S.K.D., L.H.M.) and Departments of Oncology (S.K.D., L.P., K.W., J.K., Z.H., C.C., L.H.M.) and Pharmacology (L.H.M.), Wayne State University School of Medicine, Detroit, Michigan; Molecular Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Detroit, Michigan (L.P., Z.H., C.C., L.H.M.); Department of Pediatrics, Children's Hospital of Michigan, Detroit, Michigan (M.S.); and Division of Medicinal Chemistry, Graduate School of Pharmaceutical Science, Duquesne University, Pittsburgh, Pennsylvania (L.W., A.G.)
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Mark Stout
Graduate Program in Cancer Biology (S.K.D., L.H.M.) and Departments of Oncology (S.K.D., L.P., K.W., J.K., Z.H., C.C., L.H.M.) and Pharmacology (L.H.M.), Wayne State University School of Medicine, Detroit, Michigan; Molecular Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Detroit, Michigan (L.P., Z.H., C.C., L.H.M.); Department of Pediatrics, Children's Hospital of Michigan, Detroit, Michigan (M.S.); and Division of Medicinal Chemistry, Graduate School of Pharmaceutical Science, Duquesne University, Pittsburgh, Pennsylvania (L.W., A.G.)
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Zhanjun Hou
Graduate Program in Cancer Biology (S.K.D., L.H.M.) and Departments of Oncology (S.K.D., L.P., K.W., J.K., Z.H., C.C., L.H.M.) and Pharmacology (L.H.M.), Wayne State University School of Medicine, Detroit, Michigan; Molecular Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Detroit, Michigan (L.P., Z.H., C.C., L.H.M.); Department of Pediatrics, Children's Hospital of Michigan, Detroit, Michigan (M.S.); and Division of Medicinal Chemistry, Graduate School of Pharmaceutical Science, Duquesne University, Pittsburgh, Pennsylvania (L.W., A.G.)
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Christina Cherian
Graduate Program in Cancer Biology (S.K.D., L.H.M.) and Departments of Oncology (S.K.D., L.P., K.W., J.K., Z.H., C.C., L.H.M.) and Pharmacology (L.H.M.), Wayne State University School of Medicine, Detroit, Michigan; Molecular Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Detroit, Michigan (L.P., Z.H., C.C., L.H.M.); Department of Pediatrics, Children's Hospital of Michigan, Detroit, Michigan (M.S.); and Division of Medicinal Chemistry, Graduate School of Pharmaceutical Science, Duquesne University, Pittsburgh, Pennsylvania (L.W., A.G.)
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Aleem Gangjee
Graduate Program in Cancer Biology (S.K.D., L.H.M.) and Departments of Oncology (S.K.D., L.P., K.W., J.K., Z.H., C.C., L.H.M.) and Pharmacology (L.H.M.), Wayne State University School of Medicine, Detroit, Michigan; Molecular Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Detroit, Michigan (L.P., Z.H., C.C., L.H.M.); Department of Pediatrics, Children's Hospital of Michigan, Detroit, Michigan (M.S.); and Division of Medicinal Chemistry, Graduate School of Pharmaceutical Science, Duquesne University, Pittsburgh, Pennsylvania (L.W., A.G.)
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Larry H. Matherly
Graduate Program in Cancer Biology (S.K.D., L.H.M.) and Departments of Oncology (S.K.D., L.P., K.W., J.K., Z.H., C.C., L.H.M.) and Pharmacology (L.H.M.), Wayne State University School of Medicine, Detroit, Michigan; Molecular Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Detroit, Michigan (L.P., Z.H., C.C., L.H.M.); Department of Pediatrics, Children's Hospital of Michigan, Detroit, Michigan (M.S.); and Division of Medicinal Chemistry, Graduate School of Pharmaceutical Science, Duquesne University, Pittsburgh, Pennsylvania (L.W., A.G.)
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Article Information

vol. 82 no. 4 591-600
DOI 
https://doi.org/10.1124/mol.112.079004
PubMed 
22740639

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received March 29, 2012
  • Accepted June 26, 2012
  • Published online September 26, 2012.

Article Versions

  • Earlier version (June 26, 2012 - 11:22).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2012 The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Sita Kugel Desmoulin,
  2. Lei Wang,
  3. Lisa Polin,
  4. Kathryn White,
  5. Juiwanna Kushner,
  6. Mark Stout,
  7. Zhanjun Hou,
  8. Christina Cherian,
  9. Aleem Gangjee, and
  10. Larry H. Matherly
  1. Graduate Program in Cancer Biology (S.K.D., L.H.M.) and Departments of Oncology (S.K.D., L.P., K.W., J.K., Z.H., C.C., L.H.M.) and Pharmacology (L.H.M.), Wayne State University School of Medicine, Detroit, Michigan; Molecular Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Detroit, Michigan (L.P., Z.H., C.C., L.H.M.); Department of Pediatrics, Children's Hospital of Michigan, Detroit, Michigan (M.S.); and Division of Medicinal Chemistry, Graduate School of Pharmaceutical Science, Duquesne University, Pittsburgh, Pennsylvania (L.W., A.G.)
  1. Address correspondence to:
    Dr. Larry H. Matherly, Barbara Ann Karmanos Cancer Institute, 110 E. Warren Ave., Detroit, MI 48201. E-mail: matherly{at}karmanos.org
  1. A.G. and L.H.M. contributed equally to this work.

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Molecular Pharmacology: 82 (4)
Molecular Pharmacology
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1 Oct 2012
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Research ArticleArticle

Impact of RFC on PCFT-Targeted Therapeutics

Sita Kugel Desmoulin, Lei Wang, Lisa Polin, Kathryn White, Juiwanna Kushner, Mark Stout, Zhanjun Hou, Christina Cherian, Aleem Gangjee and Larry H. Matherly
Molecular Pharmacology October 1, 2012, 82 (4) 591-600; DOI: https://doi.org/10.1124/mol.112.079004

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Research ArticleArticle

Impact of RFC on PCFT-Targeted Therapeutics

Sita Kugel Desmoulin, Lei Wang, Lisa Polin, Kathryn White, Juiwanna Kushner, Mark Stout, Zhanjun Hou, Christina Cherian, Aleem Gangjee and Larry H. Matherly
Molecular Pharmacology October 1, 2012, 82 (4) 591-600; DOI: https://doi.org/10.1124/mol.112.079004
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