Skip to main content
Advertisement

Main menu

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET

User menu

  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Molecular Pharmacology
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET
  • My alerts
  • Log in
  • My Cart
Molecular Pharmacology

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Visit molpharm on Facebook
  • Follow molpharm on Twitter
  • Follow molpharm on LinkedIn
Research ArticleArticle

Functional Loss of the Reduced Folate Carrier Enhances the Antitumor Activities of Novel Antifolates with Selective Uptake by the Proton-Coupled Folate Transporter

Sita Kugel Desmoulin, Lei Wang, Lisa Polin, Kathryn White, Juiwanna Kushner, Mark Stout, Zhanjun Hou, Christina Cherian, Aleem Gangjee and Larry H. Matherly
Molecular Pharmacology October 2012, 82 (4) 591-600; DOI: https://doi.org/10.1124/mol.112.079004
Sita Kugel Desmoulin
Graduate Program in Cancer Biology (S.K.D., L.H.M.) and Departments of Oncology (S.K.D., L.P., K.W., J.K., Z.H., C.C., L.H.M.) and Pharmacology (L.H.M.), Wayne State University School of Medicine, Detroit, Michigan; Molecular Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Detroit, Michigan (L.P., Z.H., C.C., L.H.M.); Department of Pediatrics, Children's Hospital of Michigan, Detroit, Michigan (M.S.); and Division of Medicinal Chemistry, Graduate School of Pharmaceutical Science, Duquesne University, Pittsburgh, Pennsylvania (L.W., A.G.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Lei Wang
Graduate Program in Cancer Biology (S.K.D., L.H.M.) and Departments of Oncology (S.K.D., L.P., K.W., J.K., Z.H., C.C., L.H.M.) and Pharmacology (L.H.M.), Wayne State University School of Medicine, Detroit, Michigan; Molecular Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Detroit, Michigan (L.P., Z.H., C.C., L.H.M.); Department of Pediatrics, Children's Hospital of Michigan, Detroit, Michigan (M.S.); and Division of Medicinal Chemistry, Graduate School of Pharmaceutical Science, Duquesne University, Pittsburgh, Pennsylvania (L.W., A.G.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Lisa Polin
Graduate Program in Cancer Biology (S.K.D., L.H.M.) and Departments of Oncology (S.K.D., L.P., K.W., J.K., Z.H., C.C., L.H.M.) and Pharmacology (L.H.M.), Wayne State University School of Medicine, Detroit, Michigan; Molecular Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Detroit, Michigan (L.P., Z.H., C.C., L.H.M.); Department of Pediatrics, Children's Hospital of Michigan, Detroit, Michigan (M.S.); and Division of Medicinal Chemistry, Graduate School of Pharmaceutical Science, Duquesne University, Pittsburgh, Pennsylvania (L.W., A.G.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Kathryn White
Graduate Program in Cancer Biology (S.K.D., L.H.M.) and Departments of Oncology (S.K.D., L.P., K.W., J.K., Z.H., C.C., L.H.M.) and Pharmacology (L.H.M.), Wayne State University School of Medicine, Detroit, Michigan; Molecular Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Detroit, Michigan (L.P., Z.H., C.C., L.H.M.); Department of Pediatrics, Children's Hospital of Michigan, Detroit, Michigan (M.S.); and Division of Medicinal Chemistry, Graduate School of Pharmaceutical Science, Duquesne University, Pittsburgh, Pennsylvania (L.W., A.G.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Juiwanna Kushner
Graduate Program in Cancer Biology (S.K.D., L.H.M.) and Departments of Oncology (S.K.D., L.P., K.W., J.K., Z.H., C.C., L.H.M.) and Pharmacology (L.H.M.), Wayne State University School of Medicine, Detroit, Michigan; Molecular Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Detroit, Michigan (L.P., Z.H., C.C., L.H.M.); Department of Pediatrics, Children's Hospital of Michigan, Detroit, Michigan (M.S.); and Division of Medicinal Chemistry, Graduate School of Pharmaceutical Science, Duquesne University, Pittsburgh, Pennsylvania (L.W., A.G.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Mark Stout
Graduate Program in Cancer Biology (S.K.D., L.H.M.) and Departments of Oncology (S.K.D., L.P., K.W., J.K., Z.H., C.C., L.H.M.) and Pharmacology (L.H.M.), Wayne State University School of Medicine, Detroit, Michigan; Molecular Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Detroit, Michigan (L.P., Z.H., C.C., L.H.M.); Department of Pediatrics, Children's Hospital of Michigan, Detroit, Michigan (M.S.); and Division of Medicinal Chemistry, Graduate School of Pharmaceutical Science, Duquesne University, Pittsburgh, Pennsylvania (L.W., A.G.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Zhanjun Hou
Graduate Program in Cancer Biology (S.K.D., L.H.M.) and Departments of Oncology (S.K.D., L.P., K.W., J.K., Z.H., C.C., L.H.M.) and Pharmacology (L.H.M.), Wayne State University School of Medicine, Detroit, Michigan; Molecular Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Detroit, Michigan (L.P., Z.H., C.C., L.H.M.); Department of Pediatrics, Children's Hospital of Michigan, Detroit, Michigan (M.S.); and Division of Medicinal Chemistry, Graduate School of Pharmaceutical Science, Duquesne University, Pittsburgh, Pennsylvania (L.W., A.G.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Christina Cherian
Graduate Program in Cancer Biology (S.K.D., L.H.M.) and Departments of Oncology (S.K.D., L.P., K.W., J.K., Z.H., C.C., L.H.M.) and Pharmacology (L.H.M.), Wayne State University School of Medicine, Detroit, Michigan; Molecular Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Detroit, Michigan (L.P., Z.H., C.C., L.H.M.); Department of Pediatrics, Children's Hospital of Michigan, Detroit, Michigan (M.S.); and Division of Medicinal Chemistry, Graduate School of Pharmaceutical Science, Duquesne University, Pittsburgh, Pennsylvania (L.W., A.G.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Aleem Gangjee
Graduate Program in Cancer Biology (S.K.D., L.H.M.) and Departments of Oncology (S.K.D., L.P., K.W., J.K., Z.H., C.C., L.H.M.) and Pharmacology (L.H.M.), Wayne State University School of Medicine, Detroit, Michigan; Molecular Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Detroit, Michigan (L.P., Z.H., C.C., L.H.M.); Department of Pediatrics, Children's Hospital of Michigan, Detroit, Michigan (M.S.); and Division of Medicinal Chemistry, Graduate School of Pharmaceutical Science, Duquesne University, Pittsburgh, Pennsylvania (L.W., A.G.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Larry H. Matherly
Graduate Program in Cancer Biology (S.K.D., L.H.M.) and Departments of Oncology (S.K.D., L.P., K.W., J.K., Z.H., C.C., L.H.M.) and Pharmacology (L.H.M.), Wayne State University School of Medicine, Detroit, Michigan; Molecular Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Detroit, Michigan (L.P., Z.H., C.C., L.H.M.); Department of Pediatrics, Children's Hospital of Michigan, Detroit, Michigan (M.S.); and Division of Medicinal Chemistry, Graduate School of Pharmaceutical Science, Duquesne University, Pittsburgh, Pennsylvania (L.W., A.G.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF + SI
  • PDF
Loading
Submit a Response to This Article
Compose eLetter

More information about text formats

Plain text

  • No HTML tags allowed.
  • Web page addresses and e-mail addresses turn into links automatically.
  • Lines and paragraphs break automatically.
Author Information
First or given name, e.g. 'Peter'.
Your last, or family, name, e.g. 'MacMoody'.
Your email address, e.g. higgs-boson@gmail.com
Your role and/or occupation, e.g. 'Orthopedic Surgeon'.
Your organization or institution (if applicable), e.g. 'Royal Free Hospital'.
Statement of Competing Interests

Vertical Tabs

Jump to comment:

No eLetters have been published for this article.
PreviousNext
Back to top

In this issue

Molecular Pharmacology: 82 (4)
Molecular Pharmacology
Vol. 82, Issue 4
1 Oct 2012
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Index by author
  • Editorial Board (PDF)
  • Front Matter (PDF)
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for sharing this Molecular Pharmacology article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Functional Loss of the Reduced Folate Carrier Enhances the Antitumor Activities of Novel Antifolates with Selective Uptake by the Proton-Coupled Folate Transporter
(Your Name) has forwarded a page to you from Molecular Pharmacology
(Your Name) thought you would be interested in this article in Molecular Pharmacology.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Research ArticleArticle

Impact of RFC on PCFT-Targeted Therapeutics

Sita Kugel Desmoulin, Lei Wang, Lisa Polin, Kathryn White, Juiwanna Kushner, Mark Stout, Zhanjun Hou, Christina Cherian, Aleem Gangjee and Larry H. Matherly
Molecular Pharmacology October 1, 2012, 82 (4) 591-600; DOI: https://doi.org/10.1124/mol.112.079004

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

Share
Research ArticleArticle

Impact of RFC on PCFT-Targeted Therapeutics

Sita Kugel Desmoulin, Lei Wang, Lisa Polin, Kathryn White, Juiwanna Kushner, Mark Stout, Zhanjun Hou, Christina Cherian, Aleem Gangjee and Larry H. Matherly
Molecular Pharmacology October 1, 2012, 82 (4) 591-600; DOI: https://doi.org/10.1124/mol.112.079004
Reddit logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Introduction
    • Materials and Methods
    • Results
    • Discussion
    • Authorship Contributions
    • Acknowledgments
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF + SI
  • PDF

Related Articles

Cited By...

More in this TOC Section

  • Cysteine151 in Keap1 Drives CDDO-Me Pharmacodynamic Action
  • Allosteric Modulation of Metabotropic Glutamate Receptor 1
  • Mechanism of Selective Action of Paraherquamide A
Show more Articles

Similar Articles

Advertisement
  • Home
  • Alerts
Facebook   Twitter   LinkedIn   RSS

Navigate

  • Current Issue
  • Fast Forward by date
  • Fast Forward by section
  • Latest Articles
  • Archive
  • Search for Articles
  • Feedback
  • ASPET

More Information

  • About Molecular Pharmacology
  • Editorial Board
  • Instructions to Authors
  • Submit a Manuscript
  • Customized Alerts
  • RSS Feeds
  • Subscriptions
  • Permissions
  • Terms & Conditions of Use

ASPET's Other Journals

  • Drug Metabolism and Disposition
  • Journal of Pharmacology and Experimental Therapeutics
  • Pharmacological Reviews
  • Pharmacology Research & Perspectives
ISSN 1521-0111 (Online)

Copyright © 2023 by the American Society for Pharmacology and Experimental Therapeutics