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Research ArticleArticle

Anacardic Acid Inhibits the Catalytic Activity of Matrix Metalloproteinase-2 and Matrix Metalloproteinase-9

Athira Omanakuttan, Jyotsna Nambiar, Rodney M. Harris, Chinchu Bose, Nanjan Pandurangan, Rebu K. Varghese, Geetha B. Kumar, John A. Tainer, Asoke Banerji, J. Jefferson P. Perry and Bipin G. Nair
Molecular Pharmacology October 2012, 82 (4) 614-622; DOI: https://doi.org/10.1124/mol.112.079020
Athira Omanakuttan
Amrita School of Biotechnology, Amrita Vishwa Vidyapeetham, Amritapuri, Kollam, Kerala, India (A.O., J.N., C.B., N.P., R.K.V., G.B.K., A.B., J.J.P.P., B.G.N.); 1060 Discovery Engineering, San Diego, California (R.M.H.); Skaggs Institute for Chemical Biology and Department of Molecular Biology, the Scripps Research Institute, La Jolla, California (J.A.T., J.J.P.P.); and Lawrence Berkeley National Laboratory, Berkeley, California (J.A.T.)
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Jyotsna Nambiar
Amrita School of Biotechnology, Amrita Vishwa Vidyapeetham, Amritapuri, Kollam, Kerala, India (A.O., J.N., C.B., N.P., R.K.V., G.B.K., A.B., J.J.P.P., B.G.N.); 1060 Discovery Engineering, San Diego, California (R.M.H.); Skaggs Institute for Chemical Biology and Department of Molecular Biology, the Scripps Research Institute, La Jolla, California (J.A.T., J.J.P.P.); and Lawrence Berkeley National Laboratory, Berkeley, California (J.A.T.)
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Rodney M. Harris
Amrita School of Biotechnology, Amrita Vishwa Vidyapeetham, Amritapuri, Kollam, Kerala, India (A.O., J.N., C.B., N.P., R.K.V., G.B.K., A.B., J.J.P.P., B.G.N.); 1060 Discovery Engineering, San Diego, California (R.M.H.); Skaggs Institute for Chemical Biology and Department of Molecular Biology, the Scripps Research Institute, La Jolla, California (J.A.T., J.J.P.P.); and Lawrence Berkeley National Laboratory, Berkeley, California (J.A.T.)
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Chinchu Bose
Amrita School of Biotechnology, Amrita Vishwa Vidyapeetham, Amritapuri, Kollam, Kerala, India (A.O., J.N., C.B., N.P., R.K.V., G.B.K., A.B., J.J.P.P., B.G.N.); 1060 Discovery Engineering, San Diego, California (R.M.H.); Skaggs Institute for Chemical Biology and Department of Molecular Biology, the Scripps Research Institute, La Jolla, California (J.A.T., J.J.P.P.); and Lawrence Berkeley National Laboratory, Berkeley, California (J.A.T.)
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Nanjan Pandurangan
Amrita School of Biotechnology, Amrita Vishwa Vidyapeetham, Amritapuri, Kollam, Kerala, India (A.O., J.N., C.B., N.P., R.K.V., G.B.K., A.B., J.J.P.P., B.G.N.); 1060 Discovery Engineering, San Diego, California (R.M.H.); Skaggs Institute for Chemical Biology and Department of Molecular Biology, the Scripps Research Institute, La Jolla, California (J.A.T., J.J.P.P.); and Lawrence Berkeley National Laboratory, Berkeley, California (J.A.T.)
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Rebu K. Varghese
Amrita School of Biotechnology, Amrita Vishwa Vidyapeetham, Amritapuri, Kollam, Kerala, India (A.O., J.N., C.B., N.P., R.K.V., G.B.K., A.B., J.J.P.P., B.G.N.); 1060 Discovery Engineering, San Diego, California (R.M.H.); Skaggs Institute for Chemical Biology and Department of Molecular Biology, the Scripps Research Institute, La Jolla, California (J.A.T., J.J.P.P.); and Lawrence Berkeley National Laboratory, Berkeley, California (J.A.T.)
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Geetha B. Kumar
Amrita School of Biotechnology, Amrita Vishwa Vidyapeetham, Amritapuri, Kollam, Kerala, India (A.O., J.N., C.B., N.P., R.K.V., G.B.K., A.B., J.J.P.P., B.G.N.); 1060 Discovery Engineering, San Diego, California (R.M.H.); Skaggs Institute for Chemical Biology and Department of Molecular Biology, the Scripps Research Institute, La Jolla, California (J.A.T., J.J.P.P.); and Lawrence Berkeley National Laboratory, Berkeley, California (J.A.T.)
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John A. Tainer
Amrita School of Biotechnology, Amrita Vishwa Vidyapeetham, Amritapuri, Kollam, Kerala, India (A.O., J.N., C.B., N.P., R.K.V., G.B.K., A.B., J.J.P.P., B.G.N.); 1060 Discovery Engineering, San Diego, California (R.M.H.); Skaggs Institute for Chemical Biology and Department of Molecular Biology, the Scripps Research Institute, La Jolla, California (J.A.T., J.J.P.P.); and Lawrence Berkeley National Laboratory, Berkeley, California (J.A.T.)
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Asoke Banerji
Amrita School of Biotechnology, Amrita Vishwa Vidyapeetham, Amritapuri, Kollam, Kerala, India (A.O., J.N., C.B., N.P., R.K.V., G.B.K., A.B., J.J.P.P., B.G.N.); 1060 Discovery Engineering, San Diego, California (R.M.H.); Skaggs Institute for Chemical Biology and Department of Molecular Biology, the Scripps Research Institute, La Jolla, California (J.A.T., J.J.P.P.); and Lawrence Berkeley National Laboratory, Berkeley, California (J.A.T.)
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J. Jefferson P. Perry
Amrita School of Biotechnology, Amrita Vishwa Vidyapeetham, Amritapuri, Kollam, Kerala, India (A.O., J.N., C.B., N.P., R.K.V., G.B.K., A.B., J.J.P.P., B.G.N.); 1060 Discovery Engineering, San Diego, California (R.M.H.); Skaggs Institute for Chemical Biology and Department of Molecular Biology, the Scripps Research Institute, La Jolla, California (J.A.T., J.J.P.P.); and Lawrence Berkeley National Laboratory, Berkeley, California (J.A.T.)
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Bipin G. Nair
Amrita School of Biotechnology, Amrita Vishwa Vidyapeetham, Amritapuri, Kollam, Kerala, India (A.O., J.N., C.B., N.P., R.K.V., G.B.K., A.B., J.J.P.P., B.G.N.); 1060 Discovery Engineering, San Diego, California (R.M.H.); Skaggs Institute for Chemical Biology and Department of Molecular Biology, the Scripps Research Institute, La Jolla, California (J.A.T., J.J.P.P.); and Lawrence Berkeley National Laboratory, Berkeley, California (J.A.T.)
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Article Information

vol. 82 no. 4 614-622
DOI 
https://doi.org/10.1124/mol.112.079020
PubMed 
22745359

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received March 29, 2012
  • Accepted June 28, 2012
  • Published online September 26, 2012.

Article Versions

  • Earlier version (June 28, 2012 - 10:13).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2012 The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Athira Omanakuttan,
  2. Jyotsna Nambiar,
  3. Rodney M. Harris,
  4. Chinchu Bose,
  5. Nanjan Pandurangan,
  6. Rebu K. Varghese,
  7. Geetha B. Kumar,
  8. John A. Tainer,
  9. Asoke Banerji,
  10. J. Jefferson P. Perry, and
  11. Bipin G. Nair
  1. Amrita School of Biotechnology, Amrita Vishwa Vidyapeetham, Amritapuri, Kollam, Kerala, India (A.O., J.N., C.B., N.P., R.K.V., G.B.K., A.B., J.J.P.P., B.G.N.); 1060 Discovery Engineering, San Diego, California (R.M.H.); Skaggs Institute for Chemical Biology and Department of Molecular Biology, the Scripps Research Institute, La Jolla, California (J.A.T., J.J.P.P.); and Lawrence Berkeley National Laboratory, Berkeley, California (J.A.T.)
  1. Address correspondence to:
    Dr. Bipin Nair, Dean, Amrita School of Biotechnology, Amrita Vishwa Vidyapeetham, Amritapuri, Clappana P.O, Kollam, Kerala, India- 690525. E-mail: bipin{at}amrita.edu
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Molecular Pharmacology: 82 (4)
Molecular Pharmacology
Vol. 82, Issue 4
1 Oct 2012
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Research ArticleArticle

Inhibition of Gelatinases by Anacardic Acid

Athira Omanakuttan, Jyotsna Nambiar, Rodney M. Harris, Chinchu Bose, Nanjan Pandurangan, Rebu K. Varghese, Geetha B. Kumar, John A. Tainer, Asoke Banerji, J. Jefferson P. Perry and Bipin G. Nair
Molecular Pharmacology October 1, 2012, 82 (4) 614-622; DOI: https://doi.org/10.1124/mol.112.079020

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Research ArticleArticle

Inhibition of Gelatinases by Anacardic Acid

Athira Omanakuttan, Jyotsna Nambiar, Rodney M. Harris, Chinchu Bose, Nanjan Pandurangan, Rebu K. Varghese, Geetha B. Kumar, John A. Tainer, Asoke Banerji, J. Jefferson P. Perry and Bipin G. Nair
Molecular Pharmacology October 1, 2012, 82 (4) 614-622; DOI: https://doi.org/10.1124/mol.112.079020
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