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Research ArticleArticle

P-Glycoprotein, Multidrug-Resistance Associated Protein 2, Cyp3a, and Carboxylesterase Affect the Oral Availability and Metabolism of Vinorelbine

Jurjen S. Lagas, Carola W. N. Damen, Robert A. B. van Waterschoot, Dilek Iusuf, Jos H. Beijnen and Alfred H. Schinkel
Molecular Pharmacology October 2012, 82 (4) 636-644; DOI: https://doi.org/10.1124/mol.111.077099

Article Information

vol. 82 no. 4 636-644
DOI 
https://doi.org/10.1124/mol.111.077099
PubMed 
22767610
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received December 5, 2011
  • Accepted July 5, 2012
  • Published online September 26, 2012.

Article Versions

Copyright & Usage 
Copyright © 2012 The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Jurjen S. Lagas,
  2. Carola W. N. Damen,
  3. Robert A. B. van Waterschoot,
  4. Dilek Iusuf,
  5. Jos H. Beijnen, and
  6. Alfred H. Schinkel
  1. Division of Molecular Oncology (J.S.L., R.A.B.v.W., D.I., A.H.S.), The Netherlands Cancer Institute, Amsterdam, The Netherlands; and Department of Pharmacy and Pharmacology, Slotervaart Hospital, Amsterdam, the Netherlands (J.S.L., C.W.N.D., J.H.B.)
  1. Address correspondence to:
    Dr. Jurjen S. Lagas, Department of Pharmacy and Pharmacology, Slotervaart Hospital, Louwesweg 6, 1066 EC Amsterdam, The Netherlands. E-mail: jurjen.lagas{at}slz.nl
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P-gp, Mrp2, Cyp3a, and Ces2a Affect Vinorelbine Availability

Jurjen S. Lagas, Carola W. N. Damen, Robert A. B. van Waterschoot, Dilek Iusuf, Jos H. Beijnen and Alfred H. Schinkel
Molecular Pharmacology October 1, 2012, 82 (4) 636-644; DOI: https://doi.org/10.1124/mol.111.077099
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