Research ArticleArticle
Synthesis of Selective Agonists for the α7 Nicotinic Acetylcholine Receptor with In Situ Click-Chemistry on Acetylcholine-Binding Protein Templates
John G. Yamauchi, Kimberly Gomez, Neil Grimster, Mikael Dufouil, Ákos Nemecz, Joseph R. Fotsing, Kwok-Yiu Ho, Todd T. Talley, K. Barry Sharpless, Valery V. Fokin and Palmer Taylor
Molecular Pharmacology October 2012, 82 (4) 687-699; DOI: https://doi.org/10.1124/mol.112.080291
John G. Yamauchi
Department of Pharmacology, Skaggs School of Pharmacy and Pharmaceutical Sciences (J.G.Y., K.G., M.D., Á.N., K.H., T.T.T., P.T.), and Department of Chemistry and Biochemistry, Division of Physical Sciences (Á.N.), University of California, San Diego, La Jolla, California; and Skaggs Institute for Chemical Biology, Scripps Research Institute, La Jolla, California (N.G., M.D., J.R.F., K.B.S., V.V.F.)
Kimberly Gomez
Department of Pharmacology, Skaggs School of Pharmacy and Pharmaceutical Sciences (J.G.Y., K.G., M.D., Á.N., K.H., T.T.T., P.T.), and Department of Chemistry and Biochemistry, Division of Physical Sciences (Á.N.), University of California, San Diego, La Jolla, California; and Skaggs Institute for Chemical Biology, Scripps Research Institute, La Jolla, California (N.G., M.D., J.R.F., K.B.S., V.V.F.)
Neil Grimster
Department of Pharmacology, Skaggs School of Pharmacy and Pharmaceutical Sciences (J.G.Y., K.G., M.D., Á.N., K.H., T.T.T., P.T.), and Department of Chemistry and Biochemistry, Division of Physical Sciences (Á.N.), University of California, San Diego, La Jolla, California; and Skaggs Institute for Chemical Biology, Scripps Research Institute, La Jolla, California (N.G., M.D., J.R.F., K.B.S., V.V.F.)
Mikael Dufouil
Department of Pharmacology, Skaggs School of Pharmacy and Pharmaceutical Sciences (J.G.Y., K.G., M.D., Á.N., K.H., T.T.T., P.T.), and Department of Chemistry and Biochemistry, Division of Physical Sciences (Á.N.), University of California, San Diego, La Jolla, California; and Skaggs Institute for Chemical Biology, Scripps Research Institute, La Jolla, California (N.G., M.D., J.R.F., K.B.S., V.V.F.)
Ákos Nemecz
Department of Pharmacology, Skaggs School of Pharmacy and Pharmaceutical Sciences (J.G.Y., K.G., M.D., Á.N., K.H., T.T.T., P.T.), and Department of Chemistry and Biochemistry, Division of Physical Sciences (Á.N.), University of California, San Diego, La Jolla, California; and Skaggs Institute for Chemical Biology, Scripps Research Institute, La Jolla, California (N.G., M.D., J.R.F., K.B.S., V.V.F.)
Joseph R. Fotsing
Department of Pharmacology, Skaggs School of Pharmacy and Pharmaceutical Sciences (J.G.Y., K.G., M.D., Á.N., K.H., T.T.T., P.T.), and Department of Chemistry and Biochemistry, Division of Physical Sciences (Á.N.), University of California, San Diego, La Jolla, California; and Skaggs Institute for Chemical Biology, Scripps Research Institute, La Jolla, California (N.G., M.D., J.R.F., K.B.S., V.V.F.)
Kwok-Yiu Ho
Department of Pharmacology, Skaggs School of Pharmacy and Pharmaceutical Sciences (J.G.Y., K.G., M.D., Á.N., K.H., T.T.T., P.T.), and Department of Chemistry and Biochemistry, Division of Physical Sciences (Á.N.), University of California, San Diego, La Jolla, California; and Skaggs Institute for Chemical Biology, Scripps Research Institute, La Jolla, California (N.G., M.D., J.R.F., K.B.S., V.V.F.)
Todd T. Talley
Department of Pharmacology, Skaggs School of Pharmacy and Pharmaceutical Sciences (J.G.Y., K.G., M.D., Á.N., K.H., T.T.T., P.T.), and Department of Chemistry and Biochemistry, Division of Physical Sciences (Á.N.), University of California, San Diego, La Jolla, California; and Skaggs Institute for Chemical Biology, Scripps Research Institute, La Jolla, California (N.G., M.D., J.R.F., K.B.S., V.V.F.)
K. Barry Sharpless
Department of Pharmacology, Skaggs School of Pharmacy and Pharmaceutical Sciences (J.G.Y., K.G., M.D., Á.N., K.H., T.T.T., P.T.), and Department of Chemistry and Biochemistry, Division of Physical Sciences (Á.N.), University of California, San Diego, La Jolla, California; and Skaggs Institute for Chemical Biology, Scripps Research Institute, La Jolla, California (N.G., M.D., J.R.F., K.B.S., V.V.F.)
Valery V. Fokin
Department of Pharmacology, Skaggs School of Pharmacy and Pharmaceutical Sciences (J.G.Y., K.G., M.D., Á.N., K.H., T.T.T., P.T.), and Department of Chemistry and Biochemistry, Division of Physical Sciences (Á.N.), University of California, San Diego, La Jolla, California; and Skaggs Institute for Chemical Biology, Scripps Research Institute, La Jolla, California (N.G., M.D., J.R.F., K.B.S., V.V.F.)
Palmer Taylor
Department of Pharmacology, Skaggs School of Pharmacy and Pharmaceutical Sciences (J.G.Y., K.G., M.D., Á.N., K.H., T.T.T., P.T.), and Department of Chemistry and Biochemistry, Division of Physical Sciences (Á.N.), University of California, San Diego, La Jolla, California; and Skaggs Institute for Chemical Biology, Scripps Research Institute, La Jolla, California (N.G., M.D., J.R.F., K.B.S., V.V.F.)

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Research ArticleArticle
nAChR Click-Chemistry Synthesis and Pharmacological Features
John G. Yamauchi, Kimberly Gomez, Neil Grimster, Mikael Dufouil, Ákos Nemecz, Joseph R. Fotsing, Kwok-Yiu Ho, Todd T. Talley, K. Barry Sharpless, Valery V. Fokin and Palmer Taylor
Molecular Pharmacology October 1, 2012, 82 (4) 687-699; DOI: https://doi.org/10.1124/mol.112.080291
Research ArticleArticle
nAChR Click-Chemistry Synthesis and Pharmacological Features
John G. Yamauchi, Kimberly Gomez, Neil Grimster, Mikael Dufouil, Ákos Nemecz, Joseph R. Fotsing, Kwok-Yiu Ho, Todd T. Talley, K. Barry Sharpless, Valery V. Fokin and Palmer Taylor
Molecular Pharmacology October 1, 2012, 82 (4) 687-699; DOI: https://doi.org/10.1124/mol.112.080291
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