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Research ArticleArticle

Efficient Binding of 4/7 α-Conotoxins to Nicotinic α4β2 Receptors Is Prevented by Arg185 and Pro195 in the α4 Subunit

Mirko Beissner, Sébastien Dutertre, Rudolf Schemm, Timm Danker, Annett Sporning, Helmut Grubmüller and Annette Nicke
Molecular Pharmacology October 2012, 82 (4) 711-718; DOI: https://doi.org/10.1124/mol.112.078683
Mirko Beissner
Department of Neurochemistry, Max Planck Institute for Brain Research, Frankfurt, Germany (M.B., A.N.); Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia (S.D.); Department of Theoretical and Computational Biophysics, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany (R.S., H.G.); NMI Technologie Transfer GmbH, Reutlingen, Germany (T.D.); and Department of Molecular Biology of Neuronal Signals, Max Planck Institute for Experimental Medicine, Göttingen, Germany (A.S., A.N.)
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Sébastien Dutertre
Department of Neurochemistry, Max Planck Institute for Brain Research, Frankfurt, Germany (M.B., A.N.); Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia (S.D.); Department of Theoretical and Computational Biophysics, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany (R.S., H.G.); NMI Technologie Transfer GmbH, Reutlingen, Germany (T.D.); and Department of Molecular Biology of Neuronal Signals, Max Planck Institute for Experimental Medicine, Göttingen, Germany (A.S., A.N.)
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Rudolf Schemm
Department of Neurochemistry, Max Planck Institute for Brain Research, Frankfurt, Germany (M.B., A.N.); Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia (S.D.); Department of Theoretical and Computational Biophysics, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany (R.S., H.G.); NMI Technologie Transfer GmbH, Reutlingen, Germany (T.D.); and Department of Molecular Biology of Neuronal Signals, Max Planck Institute for Experimental Medicine, Göttingen, Germany (A.S., A.N.)
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Timm Danker
Department of Neurochemistry, Max Planck Institute for Brain Research, Frankfurt, Germany (M.B., A.N.); Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia (S.D.); Department of Theoretical and Computational Biophysics, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany (R.S., H.G.); NMI Technologie Transfer GmbH, Reutlingen, Germany (T.D.); and Department of Molecular Biology of Neuronal Signals, Max Planck Institute for Experimental Medicine, Göttingen, Germany (A.S., A.N.)
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Annett Sporning
Department of Neurochemistry, Max Planck Institute for Brain Research, Frankfurt, Germany (M.B., A.N.); Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia (S.D.); Department of Theoretical and Computational Biophysics, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany (R.S., H.G.); NMI Technologie Transfer GmbH, Reutlingen, Germany (T.D.); and Department of Molecular Biology of Neuronal Signals, Max Planck Institute for Experimental Medicine, Göttingen, Germany (A.S., A.N.)
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Helmut Grubmüller
Department of Neurochemistry, Max Planck Institute for Brain Research, Frankfurt, Germany (M.B., A.N.); Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia (S.D.); Department of Theoretical and Computational Biophysics, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany (R.S., H.G.); NMI Technologie Transfer GmbH, Reutlingen, Germany (T.D.); and Department of Molecular Biology of Neuronal Signals, Max Planck Institute for Experimental Medicine, Göttingen, Germany (A.S., A.N.)
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Annette Nicke
Department of Neurochemistry, Max Planck Institute for Brain Research, Frankfurt, Germany (M.B., A.N.); Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia (S.D.); Department of Theoretical and Computational Biophysics, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany (R.S., H.G.); NMI Technologie Transfer GmbH, Reutlingen, Germany (T.D.); and Department of Molecular Biology of Neuronal Signals, Max Planck Institute for Experimental Medicine, Göttingen, Germany (A.S., A.N.)
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Article Information

vol. 82 no. 4 711-718
DOI 
https://doi.org/10.1124/mol.112.078683
PubMed 
22802270

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received March 17, 2012
  • Accepted July 16, 2012
  • Published online September 26, 2012.

Article Versions

  • Earlier version (July 16, 2012 - 10:31).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2012 The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Mirko Beissner,
  2. Sébastien Dutertre,
  3. Rudolf Schemm,
  4. Timm Danker,
  5. Annett Sporning,
  6. Helmut Grubmüller, and
  7. Annette Nicke
  1. Department of Neurochemistry, Max Planck Institute for Brain Research, Frankfurt, Germany (M.B., A.N.); Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia (S.D.); Department of Theoretical and Computational Biophysics, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany (R.S., H.G.); NMI Technologie Transfer GmbH, Reutlingen, Germany (T.D.); and Department of Molecular Biology of Neuronal Signals, Max Planck Institute for Experimental Medicine, Göttingen, Germany (A.S., A.N.)
  1. Address correspondence to:
    Dr. Annette Nicke, Max Planck Institute for Experimental Medicine, Hermann-Rein-Str. 3, 37075 Göttingen, Germany. E-mail: anicke{at}gwdg.de
  1. M.B., S.D., and R.S. contributed equally to this work.

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Molecular Pharmacology: 82 (4)
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Vol. 82, Issue 4
1 Oct 2012
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Research ArticleArticle

α-Conotoxin Binding to α4β2 Receptors

Mirko Beissner, Sébastien Dutertre, Rudolf Schemm, Timm Danker, Annett Sporning, Helmut Grubmüller and Annette Nicke
Molecular Pharmacology October 1, 2012, 82 (4) 711-718; DOI: https://doi.org/10.1124/mol.112.078683

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Research ArticleArticle

α-Conotoxin Binding to α4β2 Receptors

Mirko Beissner, Sébastien Dutertre, Rudolf Schemm, Timm Danker, Annett Sporning, Helmut Grubmüller and Annette Nicke
Molecular Pharmacology October 1, 2012, 82 (4) 711-718; DOI: https://doi.org/10.1124/mol.112.078683
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