Table of Contents

Articles

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  Cysteine Residues in the Transmembrane (TM) 9 to TM11 Region of the Human Equilibrative Nucleoside Transporter Subtype 1 Play an Important Role in Inhibitor Binding and Translocation Function

  Jamie S. Park and James R. Hammond

  Molecular Pharmacology November 2012, 82 (5) 784-794; DOI: https://doi.org/10.1124/mol.112.079616
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  Structure-Activity Relationship of Fenamates as Slo2.1 Channel Activators

  Priyanka Garg and Michael C. Sanguinetti

  Molecular Pharmacology November 2012, 82 (5) 795-802; DOI: https://doi.org/10.1124/mol.112.079194
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  Molecular Mechanisms of Chloroquine Inhibition of Heterologously Expressed Kir6.2/SUR2A Channels

  Daniela Ponce-Balbuena, Aldo A. Rodríguez-Menchaca, Angélica López-Izquierdo, Tania Ferrer, Harley T. Kurata, Colin G. Nichols and José A. Sánchez-Chapula

  Molecular Pharmacology November 2012, 82 (5) 803-813; DOI: https://doi.org/10.1124/mol.112.079152
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  P6981, An Arylstibonic Acid, Is a Novel Low Nanomolar Inhibitor of cAMP Response Element-Binding Protein Binding to DNA

  Jianfei Zhao, Jason R. Stagno, Lyuba Varticovski, Eric Nimako, Vikas Rishi, Kathy McKinnon, Rhone Akee, Robert H. Shoemaker, Xinhua Ji and Charles Vinson

  Molecular Pharmacology November 2012, 82 (5) 814-823; DOI: https://doi.org/10.1124/mol.112.080820
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  In Silico and Intuitive Predictions of CYP46A1 Inhibition by Marketed Drugs with Subsequent Enzyme Crystallization in Complex with Fluvoxamine

  Natalia Mast, Marlin Linger, Matthew Clark, Jeffrey Wiseman, C. David Stout and Irina A. Pikuleva

  Molecular Pharmacology November 2012, 82 (5) 824-834; DOI: https://doi.org/10.1124/mol.112.080424
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  Cytochrome P450 Architecture and Cysteine Nucleophile Placement Impact Raloxifene-Mediated Mechanism-Based Inactivation

  Brooke M. VandenBrink, John A. Davis, Josh T. Pearson, Robert S. Foti, Larry C. Wienkers and Dan A. Rock

  Molecular Pharmacology November 2012, 82 (5) 835-842; DOI: https://doi.org/10.1124/mol.112.080739
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  Identification and Pharmacological Characterization of Multiple Allosteric Binding Sites on the Free Fatty Acid 1 Receptor

  Daniel C.-H. Lin, Qi Guo, Jian Luo, Jane Zhang, Kathy Nguyen, Michael Chen, Thanh Tran, Paul J. Dransfield, Sean P. Brown, Jonathan Houze, Marc Vimolratana, Xian Yun Jiao, Yingcai Wang, Nigel J. M. Birdsall and Gayathri Swaminath

  Molecular Pharmacology November 2012, 82 (5) 843-859; DOI: https://doi.org/10.1124/mol.112.079640
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  Investigating Metabotropic Glutamate Receptor 5 Allosteric Modulator Cooperativity, Affinity, and Agonism: Enriching Structure-Function Studies and Structure-Activity Relationships

  Karen J. Gregory, Meredith J. Noetzel, Jerri M. Rook, Paige N. Vinson, Shaun R. Stauffer, Alice L. Rodriguez, Kyle A. Emmitte, Ya Zhou, Aspen C. Chun, Andrew S. Felts, Brian A. Chauder, Craig W. Lindsley, Colleen M. Niswender and P. Jeffrey Conn

  Molecular Pharmacology November 2012, 82 (5) 860-875; DOI: https://doi.org/10.1124/mol.112.080531
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  Chaperone Heat Shock Protein 90 Mobilization and Hydralazine Cytoprotection against Acrolein-Induced Carbonyl Stress

  Philip C. Burcham, Albert Raso and Lisa M. Kaminskas

  Molecular Pharmacology November 2012, 82 (5) 876-886; DOI: https://doi.org/10.1124/mol.112.078956
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  Redox Regulation by Nuclear Factor Erythroid 2-Related Factor 2: Gatekeeping for the Basal and Diabetes-Induced Expression of Thioredoxin-Interacting Protein

  Xiaoqing He and Qiang Ma

  Molecular Pharmacology November 2012, 82 (5) 887-897; DOI: https://doi.org/10.1124/mol.112.081133
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  A Second Extracellular Site Is Required for Norepinephrine Transport by the Human Norepinephrine Transporter

  Ching-I A. Wang, Nausad H. Shaikh, Soumya Ramu and Richard J. Lewis

  Molecular Pharmacology November 2012, 82 (5) 898-909; DOI: https://doi.org/10.1124/mol.112.080630
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  Activation of α7 Nicotinic Receptors by Orthosteric and Allosteric Agonists: Influence on Single-Channel Kinetics and Conductance

  Magda M. Pałczyńska, Marie Jindrichova, Alasdair J. Gibb and Neil S. Millar

  Molecular Pharmacology November 2012, 82 (5) 910-917; DOI: https://doi.org/10.1124/mol.112.080259
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  The Orphan Nuclear Receptor DAX-1 Functions as a Potent Corepressor of the Constitutive Androstane Receptor (NR1I3)

  Elizabeth M. Laurenzana, Tao Chen, Malavika Kannuswamy, Brian E. Sell, Stephen C. Strom, Yong Li and Curtis J. Omiecinski

  Molecular Pharmacology November 2012, 82 (5) 918-928; DOI: https://doi.org/10.1124/mol.112.080721
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  Pharmacological Characterization and Modeling of the Binding Sites of Novel 1,3-Bis(pyridinylethynyl)benzenes as Metabotropic Glutamate Receptor 5-Selective Negative Allosteric Modulators

  Christina Mølck, Kasper Harpsøe, David E. Gloriam, Rasmus P. Clausen, Ulf Madsen, Lars Ø. Pedersen, Hermogenes N. Jimenez, Søren M. Nielsen, Jesper M. Mathiesen and Hans Bräuner-Osborne

  Molecular Pharmacology November 2012, 82 (5) 929-937; DOI: https://doi.org/10.1124/mol.112.078808
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  Molecular Characteristics of CTA056, a Novel Interleukin-2-Inducible T-Cell Kinase Inhibitor that Selectively Targets Malignant T Cells and Modulates Oncomirs

  Wenchang Guo, Ruiwu Liu, Yoko Ono, Ai-Hong Ma, Anthony Martinez, Eduardo Sanchez, Yan Wang, Wenzhe Huang, Anisha Mazloom, Jixian Li, Jinying Ning, Emanual Maverakis, Kit S. Lam and Hsing-Jien Kung

  Molecular Pharmacology November 2012, 82 (5) 938-947; DOI: https://doi.org/10.1124/mol.112.079889
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  Tumor Necrosis Factor-Like Weak Inducer of Apoptosis Induces Astrocyte Proliferation through the Activation of Transforming-Growth Factor-α/Epidermal Growth Factor Receptor Signaling Pathway

  Estelle Rousselet, Sabine Traver, Yann Monnet, Aline Perrin, Nathalie Mandjee, Audrey Hild, Etienne C. Hirsch, Timothy S. Zheng and Stéphane Hunot

  Molecular Pharmacology November 2012, 82 (5) 948-957; DOI: https://doi.org/10.1124/mol.112.079608
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  LYG-202 Augments Tumor Necrosis Factor-α-Induced Apoptosis via Attenuating Casein Kinase 2-Dependent Nuclear Factor-κB Pathway in HepG2 Cells

  Fei-hong Chen, Na Lu, Hai-wei Zhang, Li Zhao, Li-cheng He, Hao-peng Sun, Qi-dong You, Zhi-yu Li and Qing-long Guo

  Molecular Pharmacology November 2012, 82 (5) 958-971; DOI: https://doi.org/10.1124/mol.112.079848
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  α-Conotoxin PeIA[S9H,V10A,E14N] Potently and Selectively Blocks α6β2β3 versus α6β4 Nicotinic Acetylcholine Receptors

  Arik J. Hone, Mick'l Scadden, Joanna Gajewiak, Sean Christensen, Jon Lindstrom and J. Michael McIntosh

  Molecular Pharmacology November 2012, 82 (5) 972-982; DOI: https://doi.org/10.1124/mol.112.080853
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  Morphine Desensitization and Cellular Tolerance Are Distinguished in Rat Locus Ceruleus Neurons

  Erica S. Levitt and John T. Williams

  Molecular Pharmacology November 2012, 82 (5) 983-992; DOI: https://doi.org/10.1124/mol.112.081547
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  Coordinated Regulation of Murine Cardiomyocyte Contractility by Nanomolar (−)-Epigallocatechin-3-Gallate, the Major Green Tea Catechin

  Wei Feng, Hyun Seok Hwang, Dmytro O. Kryshtal, Tao Yang, Isela T. Padilla, Asheesh K. Tiwary, Birgit Puschner, Isaac N. Pessah and Björn C. Knollmann

  Molecular Pharmacology November 2012, 82 (5) 993-1000; DOI: https://doi.org/10.1124/mol.112.079707
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  Critical Role for Mixed-Lineage Kinase 3 in Acetaminophen-Induced Hepatotoxicity

  Manju Sharma, Vidya Gadang and Anja Jaeschke

  Molecular Pharmacology November 2012, 82 (5) 1001-1007; DOI: https://doi.org/10.1124/mol.112.079863