Research ArticleArticle
Pharmacological Characterization and Modeling of the Binding Sites of Novel 1,3-Bis(pyridinylethynyl)benzenes as Metabotropic Glutamate Receptor 5-Selective Negative Allosteric Modulators
Christina Mølck, Kasper Harpsøe, David E. Gloriam, Rasmus P. Clausen, Ulf Madsen, Lars Ø. Pedersen, Hermogenes N. Jimenez, Søren M. Nielsen, Jesper M. Mathiesen and Hans Bräuner-Osborne
Molecular Pharmacology November 2012, 82 (5) 929-937; DOI: https://doi.org/10.1124/mol.112.078808
Christina Mølck
Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark (C.M., D.E.G., R.P.C., U.M., J.M.M., H.B.-O.); NNF Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark (K.H.); Department for Biologics (L.Ø.P.) and Department of Molecular Pharmacology (S.M.N.), H. Lundbeck A/S, Valby, Denmark; and Department of Chemical and Pharmacokinetic Science, Lundbeck Research USA, Paramus, New Jersey (H.N.J.)
Kasper Harpsøe
Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark (C.M., D.E.G., R.P.C., U.M., J.M.M., H.B.-O.); NNF Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark (K.H.); Department for Biologics (L.Ø.P.) and Department of Molecular Pharmacology (S.M.N.), H. Lundbeck A/S, Valby, Denmark; and Department of Chemical and Pharmacokinetic Science, Lundbeck Research USA, Paramus, New Jersey (H.N.J.)
David E. Gloriam
Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark (C.M., D.E.G., R.P.C., U.M., J.M.M., H.B.-O.); NNF Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark (K.H.); Department for Biologics (L.Ø.P.) and Department of Molecular Pharmacology (S.M.N.), H. Lundbeck A/S, Valby, Denmark; and Department of Chemical and Pharmacokinetic Science, Lundbeck Research USA, Paramus, New Jersey (H.N.J.)
Rasmus P. Clausen
Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark (C.M., D.E.G., R.P.C., U.M., J.M.M., H.B.-O.); NNF Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark (K.H.); Department for Biologics (L.Ø.P.) and Department of Molecular Pharmacology (S.M.N.), H. Lundbeck A/S, Valby, Denmark; and Department of Chemical and Pharmacokinetic Science, Lundbeck Research USA, Paramus, New Jersey (H.N.J.)
Ulf Madsen
Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark (C.M., D.E.G., R.P.C., U.M., J.M.M., H.B.-O.); NNF Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark (K.H.); Department for Biologics (L.Ø.P.) and Department of Molecular Pharmacology (S.M.N.), H. Lundbeck A/S, Valby, Denmark; and Department of Chemical and Pharmacokinetic Science, Lundbeck Research USA, Paramus, New Jersey (H.N.J.)
Lars Ø. Pedersen
Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark (C.M., D.E.G., R.P.C., U.M., J.M.M., H.B.-O.); NNF Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark (K.H.); Department for Biologics (L.Ø.P.) and Department of Molecular Pharmacology (S.M.N.), H. Lundbeck A/S, Valby, Denmark; and Department of Chemical and Pharmacokinetic Science, Lundbeck Research USA, Paramus, New Jersey (H.N.J.)
Hermogenes N. Jimenez
Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark (C.M., D.E.G., R.P.C., U.M., J.M.M., H.B.-O.); NNF Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark (K.H.); Department for Biologics (L.Ø.P.) and Department of Molecular Pharmacology (S.M.N.), H. Lundbeck A/S, Valby, Denmark; and Department of Chemical and Pharmacokinetic Science, Lundbeck Research USA, Paramus, New Jersey (H.N.J.)
Søren M. Nielsen
Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark (C.M., D.E.G., R.P.C., U.M., J.M.M., H.B.-O.); NNF Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark (K.H.); Department for Biologics (L.Ø.P.) and Department of Molecular Pharmacology (S.M.N.), H. Lundbeck A/S, Valby, Denmark; and Department of Chemical and Pharmacokinetic Science, Lundbeck Research USA, Paramus, New Jersey (H.N.J.)
Jesper M. Mathiesen
Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark (C.M., D.E.G., R.P.C., U.M., J.M.M., H.B.-O.); NNF Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark (K.H.); Department for Biologics (L.Ø.P.) and Department of Molecular Pharmacology (S.M.N.), H. Lundbeck A/S, Valby, Denmark; and Department of Chemical and Pharmacokinetic Science, Lundbeck Research USA, Paramus, New Jersey (H.N.J.)
Hans Bräuner-Osborne
Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark (C.M., D.E.G., R.P.C., U.M., J.M.M., H.B.-O.); NNF Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark (K.H.); Department for Biologics (L.Ø.P.) and Department of Molecular Pharmacology (S.M.N.), H. Lundbeck A/S, Valby, Denmark; and Department of Chemical and Pharmacokinetic Science, Lundbeck Research USA, Paramus, New Jersey (H.N.J.)

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Research ArticleArticle
Binding Site Characterization of Novel NAMs on mGluR5
Christina Mølck, Kasper Harpsøe, David E. Gloriam, Rasmus P. Clausen, Ulf Madsen, Lars Ø. Pedersen, Hermogenes N. Jimenez, Søren M. Nielsen, Jesper M. Mathiesen and Hans Bräuner-Osborne
Molecular Pharmacology November 1, 2012, 82 (5) 929-937; DOI: https://doi.org/10.1124/mol.112.078808
Research ArticleArticle
Binding Site Characterization of Novel NAMs on mGluR5
Christina Mølck, Kasper Harpsøe, David E. Gloriam, Rasmus P. Clausen, Ulf Madsen, Lars Ø. Pedersen, Hermogenes N. Jimenez, Søren M. Nielsen, Jesper M. Mathiesen and Hans Bräuner-Osborne
Molecular Pharmacology November 1, 2012, 82 (5) 929-937; DOI: https://doi.org/10.1124/mol.112.078808
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