Table of Contents

Articles

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  Generation and Characterization of Novel Cytochrome P450 Cyp2c Gene Cluster Knockout and CYP2C9 Humanized Mouse Lines

  Nico Scheer, Yury Kapelyukh, Lynsey Chatham, Anja Rode, Sandra Buechel and C. Roland Wolf

  Molecular Pharmacology December 2012, 82 (6) 1022-1029; DOI: https://doi.org/10.1124/mol.112.080036
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  Resveratrol Sensitizes Acute Myelogenous Leukemia Cells to Histone Deacetylase Inhibitors through Reactive Oxygen Species-Mediated Activation of the Extrinsic Apoptotic Pathway

  Alae Yaseen, Shuang Chen, Stefanie Hock, Roberto Rosato, Paul Dent, Yun Dai and Steven Grant

  Molecular Pharmacology December 2012, 82 (6) 1030-1041; DOI: https://doi.org/10.1124/mol.112.079624
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  Locating a Plausible Binding Site for an Open-Channel Blocker, GlyH-101, in the Pore of the Cystic Fibrosis Transmembrane Conductance Regulator

  Yohei Norimatsu, Anthony Ivetac, Christopher Alexander, Nicolette O'Donnell, Leah Frye, Mark S. P. Sansom and David C. Dawson

  Molecular Pharmacology December 2012, 82 (6) 1042-1055; DOI: https://doi.org/10.1124/mol.112.080267
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  Chronic Caffeine Intake in Adult Rat Inhibits Carotid Body Sensitization Produced by Chronic Sustained Hypoxia but Maintains Intact Chemoreflex Output

  Silvia V. Conde, Maria J. Ribeiro, Ana Obeso, Ricardo Rigual, Emilia C. Monteiro and Constancio Gonzalez

  Molecular Pharmacology December 2012, 82 (6) 1056-1065; DOI: https://doi.org/10.1124/mol.112.081216
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  Small Molecule Allosteric Modulation of the Glucagon-Like Peptide-1 Receptor Enhances the Insulinotropic Effect of Oxyntomodulin

  Francis S. Willard, Denise Wootten, Aaron D. Showalter, Emilia E. Savage, James Ficorilli, Thomas B. Farb, Krister Bokvist, Jorge Alsina-Fernandez, Sebastian G. B. Furness, Arthur Christopoulos, Patrick M. Sexton and Kyle W. Sloop

  Molecular Pharmacology December 2012, 82 (6) 1066-1073; DOI: https://doi.org/10.1124/mol.112.080432
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  Ifenprodil Effects on GluN2B-Containing Glutamate Receptors

  Stacy A. Amico-Ruvio, Meaghan A. Paganelli, Jason M. Myers and Gabriela K. Popescu

  Molecular Pharmacology December 2012, 82 (6) 1074-1081; DOI: https://doi.org/10.1124/mol.112.078998
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  Xenobiotics and Loss of Cell Adhesion Drive Distinct Transcriptional Outcomes by Aryl Hydrocarbon Receptor Signaling

  Nan Hao, Kian Leong Lee, Sebastian G. B. Furness, Cecilia Bosdotter, Lorenz Poellinger and Murray L. Whitelaw

  Molecular Pharmacology December 2012, 82 (6) 1082-1093; DOI: https://doi.org/10.1124/mol.112.078873
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  Identification of Structural Motifs Critical for Epstein-Barr Virus-Induced Molecule 2 Function and Homology Modeling of the Ligand Docking Site

  Li Zhang, Amy Y. Shih, Xia V. Yang, Chester Kuei, Jiejun Wu, Xiaohu Deng, Neelakandha S. Mani, Taraneh Mirzadegan, Siquan Sun, Timothy W. Lovenberg and Changlu Liu

  Molecular Pharmacology December 2012, 82 (6) 1094-1103; DOI: https://doi.org/10.1124/mol.112.080275
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  Solute Restriction Reveals an Essential Role for clag3-Associated Channels in Malaria Parasite Nutrient Acquisition

  Ajay D. Pillai, Wang Nguitragool, Brian Lyko, Keithlee Dolinta, Michelle M. Butler, Son T. Nguyen, Norton P. Peet, Terry L. Bowlin and Sanjay A. Desai

  Molecular Pharmacology December 2012, 82 (6) 1104-1114; DOI: https://doi.org/10.1124/mol.112.081224
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  Betulinic Acid Decreases Specificity Protein 1 (Sp1) Level via Increasing the Sumoylation of Sp1 to Inhibit Lung Cancer Growth

  Tsung-I. Hsu, Mei-Chun Wang, Szu-Yu Chen, Shih-Ting Huang, Yu-Min Yeh, Wu-Chou Su, Wen-Chang Chang and Jan-Jong Hung

  Molecular Pharmacology December 2012, 82 (6) 1115-1128; DOI: https://doi.org/10.1124/mol.112.078485
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  Extracellular Quaternary Ammonium Blockade of Transient Receptor Potential Vanilloid Subtype 1 Channels Expressed in Xenopus laevis Oocytes

  Ricardo E. Rivera-Acevedo, Stephan A. Pless, Stephan K. W. Schwarz and Christopher A. Ahern

  Molecular Pharmacology December 2012, 82 (6) 1129-1135; DOI: https://doi.org/10.1124/mol.112.079277
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  Gβγ Inhibits Exocytosis via Interaction with Critical Residues on Soluble N-Ethylmaleimide-Sensitive Factor Attachment Protein-25

  Christopher A. Wells, Zack Zurawski, Katherine M. Betke, Yun Young Yim, Karren Hyde, Shelagh Rodriguez, Simon Alford and Heidi E. Hamm

  Molecular Pharmacology December 2012, 82 (6) 1136-1149; DOI: https://doi.org/10.1124/mol.112.080507
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  Identification and Characterization of Distinct C-Terminal Domains of the Human Hydroxycarboxylic Acid Receptor-2 That Are Essential for Receptor Export, Constitutive Activity, Desensitization, and Internalization

  Guo Li, Qi Zhou, Yena Yu, Linjie Chen, Ying Shi, Jiansong Luo, Jeffrey Benovic, Jianxin Lu and Naiming Zhou

  Molecular Pharmacology December 2012, 82 (6) 1150-1161; DOI: https://doi.org/10.1124/mol.112.081307
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  Virtual Screening for LPA₂-Specific Agonists Identifies a Nonlipid Compound with Antiapoptotic Actions

  Gyöngyi N. Kiss, James I. Fells, Renuka Gupte, Sue-Chin Lee, Jianxiong Liu, Nóra Nusser, Keng G. Lim, Ramesh M. Ray, Fang-Tsyr Lin, Abby L. Parrill, Balázs Sümegi, Duane D. Miller and Gabor Tigyi

  Molecular Pharmacology December 2012, 82 (6) 1162-1173; DOI: https://doi.org/10.1124/mol.112.079699
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  Analysis of Multiple Histamine H₄ Receptor Compound Classes Uncovers Gα_i Protein- and β-Arrestin2-Biased Ligands

  Saskia Nijmeijer, Henry F. Vischer, Elizabeth M. Rosethorne, Steven J. Charlton and Rob Leurs

  Molecular Pharmacology December 2012, 82 (6) 1174-1182; DOI: https://doi.org/10.1124/mol.112.080911
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  Cd²⁺ Block and Permeation of Ca_V3.1 (α1G) T-Type Calcium Channels: Candidate Mechanism for Cd²⁺ Influx

  Kyle V. Lopin, Frank Thévenod, Jessica C. Page and Stephen W. Jones

  Molecular Pharmacology December 2012, 82 (6) 1183-1193; DOI: https://doi.org/10.1124/mol.112.080176
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  Fe²⁺ Block and Permeation of Ca_V3.1 (α1G) T-Type Calcium Channels: Candidate Mechanism for Non–Transferrin-Mediated Fe²⁺ Influx

  Kyle V. Lopin, I. Patrick Gray, Carlos A. Obejero-Paz, Frank Thévenod and Stephen W. Jones

  Molecular Pharmacology December 2012, 82 (6) 1194-1204; DOI: https://doi.org/10.1124/mol.112.080184
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  Gene Expression Signature Predicting High-Grade Prostate Cancer Responses to Oxaliplatin

  Stéphane Puyo, Nadine Houédé, Audrey Kauffmann, Pierre Richaud, Jacques Robert and Philippe Pourquier

  Molecular Pharmacology December 2012, 82 (6) 1205-1216; DOI: https://doi.org/10.1124/mol.112.080333
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  Lapatinib and Obatoclax Kill Breast Cancer Cells through Reactive Oxygen Species-Dependent Endoplasmic Reticulum Stress

  Nichola Cruickshanks, Yong Tang, Laurence Booth, Hossein Hamed, Steven Grant and Paul Dent

  Molecular Pharmacology December 2012, 82 (6) 1217-1229; DOI: https://doi.org/10.1124/mol.112.081539
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  Inhibition of Autophagy as a Strategy to Augment Radiosensitization by the Dual Phosphatidylinositol 3-Kinase/Mammalian Target of Rapamycin Inhibitor NVP-BEZ235

  George J. Cerniglia, Jayashree Karar, Sonia Tyagi, Melpo Christofidou-Solomidou, Ramesh Rengan, Constantinos Koumenis and Amit Maity

  Molecular Pharmacology December 2012, 82 (6) 1230-1240; DOI: https://doi.org/10.1124/mol.112.080408
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  Analysis of Kalirin-7 Knockout Mice Reveals Different Effects in Female Mice

  Christopher M. Mazzone, Taylor P. Larese, Drew D. Kiraly, Betty A. Eipper and Richard E. Mains

  Molecular Pharmacology December 2012, 82 (6) 1241-1249; DOI: https://doi.org/10.1124/mol.112.080838