Research ArticleArticle
Small Molecule Allosteric Modulation of the Glucagon-Like Peptide-1 Receptor Enhances the Insulinotropic Effect of Oxyntomodulin
Francis S. Willard, Denise Wootten, Aaron D. Showalter, Emilia E. Savage, James Ficorilli, Thomas B. Farb, Krister Bokvist, Jorge Alsina-Fernandez, Sebastian G. B. Furness, Arthur Christopoulos, Patrick M. Sexton and Kyle W. Sloop
Molecular Pharmacology December 2012, 82 (6) 1066-1073; DOI: https://doi.org/10.1124/mol.112.080432
Francis S. Willard
Translational Science and Technologies (F.S.W.), Endocrine Discovery (A.D.S., J.F., T.B.F., K.B., K.W.S.), and BioTechnology Discovery Research (J.A.-F.), Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana; and Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences and Department of Pharmacology, Monash University, Parkville, Victoria, Australia (D.W., E.E.S., S.G.B.F., A.C., P.M.S.)
Denise Wootten
Translational Science and Technologies (F.S.W.), Endocrine Discovery (A.D.S., J.F., T.B.F., K.B., K.W.S.), and BioTechnology Discovery Research (J.A.-F.), Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana; and Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences and Department of Pharmacology, Monash University, Parkville, Victoria, Australia (D.W., E.E.S., S.G.B.F., A.C., P.M.S.)
Aaron D. Showalter
Translational Science and Technologies (F.S.W.), Endocrine Discovery (A.D.S., J.F., T.B.F., K.B., K.W.S.), and BioTechnology Discovery Research (J.A.-F.), Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana; and Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences and Department of Pharmacology, Monash University, Parkville, Victoria, Australia (D.W., E.E.S., S.G.B.F., A.C., P.M.S.)
Emilia E. Savage
Translational Science and Technologies (F.S.W.), Endocrine Discovery (A.D.S., J.F., T.B.F., K.B., K.W.S.), and BioTechnology Discovery Research (J.A.-F.), Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana; and Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences and Department of Pharmacology, Monash University, Parkville, Victoria, Australia (D.W., E.E.S., S.G.B.F., A.C., P.M.S.)
James Ficorilli
Translational Science and Technologies (F.S.W.), Endocrine Discovery (A.D.S., J.F., T.B.F., K.B., K.W.S.), and BioTechnology Discovery Research (J.A.-F.), Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana; and Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences and Department of Pharmacology, Monash University, Parkville, Victoria, Australia (D.W., E.E.S., S.G.B.F., A.C., P.M.S.)
Thomas B. Farb
Translational Science and Technologies (F.S.W.), Endocrine Discovery (A.D.S., J.F., T.B.F., K.B., K.W.S.), and BioTechnology Discovery Research (J.A.-F.), Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana; and Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences and Department of Pharmacology, Monash University, Parkville, Victoria, Australia (D.W., E.E.S., S.G.B.F., A.C., P.M.S.)
Krister Bokvist
Translational Science and Technologies (F.S.W.), Endocrine Discovery (A.D.S., J.F., T.B.F., K.B., K.W.S.), and BioTechnology Discovery Research (J.A.-F.), Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana; and Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences and Department of Pharmacology, Monash University, Parkville, Victoria, Australia (D.W., E.E.S., S.G.B.F., A.C., P.M.S.)
Jorge Alsina-Fernandez
Translational Science and Technologies (F.S.W.), Endocrine Discovery (A.D.S., J.F., T.B.F., K.B., K.W.S.), and BioTechnology Discovery Research (J.A.-F.), Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana; and Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences and Department of Pharmacology, Monash University, Parkville, Victoria, Australia (D.W., E.E.S., S.G.B.F., A.C., P.M.S.)
Sebastian G. B. Furness
Translational Science and Technologies (F.S.W.), Endocrine Discovery (A.D.S., J.F., T.B.F., K.B., K.W.S.), and BioTechnology Discovery Research (J.A.-F.), Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana; and Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences and Department of Pharmacology, Monash University, Parkville, Victoria, Australia (D.W., E.E.S., S.G.B.F., A.C., P.M.S.)
Arthur Christopoulos
Translational Science and Technologies (F.S.W.), Endocrine Discovery (A.D.S., J.F., T.B.F., K.B., K.W.S.), and BioTechnology Discovery Research (J.A.-F.), Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana; and Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences and Department of Pharmacology, Monash University, Parkville, Victoria, Australia (D.W., E.E.S., S.G.B.F., A.C., P.M.S.)
Patrick M. Sexton
Translational Science and Technologies (F.S.W.), Endocrine Discovery (A.D.S., J.F., T.B.F., K.B., K.W.S.), and BioTechnology Discovery Research (J.A.-F.), Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana; and Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences and Department of Pharmacology, Monash University, Parkville, Victoria, Australia (D.W., E.E.S., S.G.B.F., A.C., P.M.S.)
Kyle W. Sloop
Translational Science and Technologies (F.S.W.), Endocrine Discovery (A.D.S., J.F., T.B.F., K.B., K.W.S.), and BioTechnology Discovery Research (J.A.-F.), Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana; and Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences and Department of Pharmacology, Monash University, Parkville, Victoria, Australia (D.W., E.E.S., S.G.B.F., A.C., P.M.S.)

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Research ArticleArticle
Allosteric Modulation of Oxyntomodulin at the GLP-1 Receptor
Francis S. Willard, Denise Wootten, Aaron D. Showalter, Emilia E. Savage, James Ficorilli, Thomas B. Farb, Krister Bokvist, Jorge Alsina-Fernandez, Sebastian G. B. Furness, Arthur Christopoulos, Patrick M. Sexton and Kyle W. Sloop
Molecular Pharmacology December 1, 2012, 82 (6) 1066-1073; DOI: https://doi.org/10.1124/mol.112.080432
Research ArticleArticle
Allosteric Modulation of Oxyntomodulin at the GLP-1 Receptor
Francis S. Willard, Denise Wootten, Aaron D. Showalter, Emilia E. Savage, James Ficorilli, Thomas B. Farb, Krister Bokvist, Jorge Alsina-Fernandez, Sebastian G. B. Furness, Arthur Christopoulos, Patrick M. Sexton and Kyle W. Sloop
Molecular Pharmacology December 1, 2012, 82 (6) 1066-1073; DOI: https://doi.org/10.1124/mol.112.080432
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