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Research ArticleArticle

Solute Restriction Reveals an Essential Role for clag3-Associated Channels in Malaria Parasite Nutrient Acquisition

Ajay D. Pillai, Wang Nguitragool, Brian Lyko, Keithlee Dolinta, Michelle M. Butler, Son T. Nguyen, Norton P. Peet, Terry L. Bowlin and Sanjay A. Desai
Molecular Pharmacology December 2012, 82 (6) 1104-1114; DOI: https://doi.org/10.1124/mol.112.081224
Ajay D. Pillai
Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland (A.D.P., W.N., B.L., K.D., S.A.D.); and Microbiotix, Inc., Worcester, Massachusetts (M.M.B., S.T.N., N.P.P., T.L.B.)
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Wang Nguitragool
Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland (A.D.P., W.N., B.L., K.D., S.A.D.); and Microbiotix, Inc., Worcester, Massachusetts (M.M.B., S.T.N., N.P.P., T.L.B.)
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Brian Lyko
Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland (A.D.P., W.N., B.L., K.D., S.A.D.); and Microbiotix, Inc., Worcester, Massachusetts (M.M.B., S.T.N., N.P.P., T.L.B.)
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Keithlee Dolinta
Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland (A.D.P., W.N., B.L., K.D., S.A.D.); and Microbiotix, Inc., Worcester, Massachusetts (M.M.B., S.T.N., N.P.P., T.L.B.)
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Michelle M. Butler
Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland (A.D.P., W.N., B.L., K.D., S.A.D.); and Microbiotix, Inc., Worcester, Massachusetts (M.M.B., S.T.N., N.P.P., T.L.B.)
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Son T. Nguyen
Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland (A.D.P., W.N., B.L., K.D., S.A.D.); and Microbiotix, Inc., Worcester, Massachusetts (M.M.B., S.T.N., N.P.P., T.L.B.)
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Norton P. Peet
Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland (A.D.P., W.N., B.L., K.D., S.A.D.); and Microbiotix, Inc., Worcester, Massachusetts (M.M.B., S.T.N., N.P.P., T.L.B.)
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Terry L. Bowlin
Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland (A.D.P., W.N., B.L., K.D., S.A.D.); and Microbiotix, Inc., Worcester, Massachusetts (M.M.B., S.T.N., N.P.P., T.L.B.)
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Sanjay A. Desai
Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland (A.D.P., W.N., B.L., K.D., S.A.D.); and Microbiotix, Inc., Worcester, Massachusetts (M.M.B., S.T.N., N.P.P., T.L.B.)
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Article Information

vol. 82 no. 6 1104-1114
DOI 
https://doi.org/10.1124/mol.112.081224
PubMed 
22949525

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received July 13, 2012
  • Accepted September 4, 2012
  • Published online November 14, 2012.

Article Versions

  • Earlier version (September 4, 2012 - 09:57).
  • You are viewing the most recent version of this article.
Copyright & Usage 
U.S. Government work not protected by U.S. copyright

Author Information

  1. Ajay D. Pillai1,
  2. Wang Nguitragool2,
  3. Brian Lyko3,
  4. Keithlee Dolinta4,
  5. Michelle M. Butler,
  6. Son T. Nguyen,
  7. Norton P. Peet,
  8. Terry L. Bowlin, and
  9. Sanjay A. Desai
  1. Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland (A.D.P., W.N., B.L., K.D., S.A.D.); and Microbiotix, Inc., Worcester, Massachusetts (M.M.B., S.T.N., N.P.P., T.L.B.)
  1. Address correspondence to:
    Dr. Sanjay A. Desai, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 12735 Twinbrook Parkway, Room 3W-01, Rockville, MD 20852. E-mail: sdesai{at}niaid.nih.gov
  1. A.D.P. and W.N. contributed equally to this work.

  • ↵1 Current affiliation: Wellcome Trust/DBT India Alliance, Hyderabad, India.

  • ↵2 Current affiliation: Department of Molecular Tropical Medicine and Genetics, Mahidol University, Bangkok, Thailand.

  • ↵3 Current affiliation: Towson University, Towson, Maryland.

  • ↵4 Current affiliation: University of Texas M.D. Anderson Cancer Center, Houston, Texas.

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Molecular Pharmacology: 82 (6)
Molecular Pharmacology
Vol. 82, Issue 6
1 Dec 2012
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Research ArticleArticle

P. falciparum Requires Channel-Mediated Nutrient Uptake

Ajay D. Pillai, Wang Nguitragool, Brian Lyko, Keithlee Dolinta, Michelle M. Butler, Son T. Nguyen, Norton P. Peet, Terry L. Bowlin and Sanjay A. Desai
Molecular Pharmacology December 1, 2012, 82 (6) 1104-1114; DOI: https://doi.org/10.1124/mol.112.081224

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Research ArticleArticle

P. falciparum Requires Channel-Mediated Nutrient Uptake

Ajay D. Pillai, Wang Nguitragool, Brian Lyko, Keithlee Dolinta, Michelle M. Butler, Son T. Nguyen, Norton P. Peet, Terry L. Bowlin and Sanjay A. Desai
Molecular Pharmacology December 1, 2012, 82 (6) 1104-1114; DOI: https://doi.org/10.1124/mol.112.081224
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