Skip to main content
Advertisement

Main menu

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET

User menu

  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Molecular Pharmacology
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET
  • My alerts
  • Log in
  • My Cart
Molecular Pharmacology

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Visit molpharm on Facebook
  • Follow molpharm on Twitter
  • Follow molpharm on LinkedIn
Research ArticleArticle

Virtual Screening for LPA2-Specific Agonists Identifies a Nonlipid Compound with Antiapoptotic Actions

Gyöngyi N. Kiss, James I. Fells, Renuka Gupte, Sue-Chin Lee, Jianxiong Liu, Nóra Nusser, Keng G. Lim, Ramesh M. Ray, Fang-Tsyr Lin, Abby L. Parrill, Balázs Sümegi, Duane D. Miller and Gabor Tigyi
Molecular Pharmacology December 2012, 82 (6) 1162-1173; DOI: https://doi.org/10.1124/mol.112.079699
Gyöngyi N. Kiss
Department of Physiology (G.N.K., J.I.F., S.-C.L., J.L., N.N., K.G.L., R.M.R., G.T.) and Department of Pharmaceutical Sciences (R.G., D.M.D.), University of Tennessee Health Science Center, Memphis, Tennessee; Department of Biochemistry and Medical Chemistry, University of Pécs, Pécs, Hungary (G.N.K., B.S.); Department of Medicine, Section of Hematology/Oncology, Baylor College of Medicine, Houston, Texas (F.-T.L.); and Computational Research on Materials Institute, Department of Chemistry, University of Memphis, Tennessee (A.L.P.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
James I. Fells
Department of Physiology (G.N.K., J.I.F., S.-C.L., J.L., N.N., K.G.L., R.M.R., G.T.) and Department of Pharmaceutical Sciences (R.G., D.M.D.), University of Tennessee Health Science Center, Memphis, Tennessee; Department of Biochemistry and Medical Chemistry, University of Pécs, Pécs, Hungary (G.N.K., B.S.); Department of Medicine, Section of Hematology/Oncology, Baylor College of Medicine, Houston, Texas (F.-T.L.); and Computational Research on Materials Institute, Department of Chemistry, University of Memphis, Tennessee (A.L.P.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Renuka Gupte
Department of Physiology (G.N.K., J.I.F., S.-C.L., J.L., N.N., K.G.L., R.M.R., G.T.) and Department of Pharmaceutical Sciences (R.G., D.M.D.), University of Tennessee Health Science Center, Memphis, Tennessee; Department of Biochemistry and Medical Chemistry, University of Pécs, Pécs, Hungary (G.N.K., B.S.); Department of Medicine, Section of Hematology/Oncology, Baylor College of Medicine, Houston, Texas (F.-T.L.); and Computational Research on Materials Institute, Department of Chemistry, University of Memphis, Tennessee (A.L.P.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Sue-Chin Lee
Department of Physiology (G.N.K., J.I.F., S.-C.L., J.L., N.N., K.G.L., R.M.R., G.T.) and Department of Pharmaceutical Sciences (R.G., D.M.D.), University of Tennessee Health Science Center, Memphis, Tennessee; Department of Biochemistry and Medical Chemistry, University of Pécs, Pécs, Hungary (G.N.K., B.S.); Department of Medicine, Section of Hematology/Oncology, Baylor College of Medicine, Houston, Texas (F.-T.L.); and Computational Research on Materials Institute, Department of Chemistry, University of Memphis, Tennessee (A.L.P.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jianxiong Liu
Department of Physiology (G.N.K., J.I.F., S.-C.L., J.L., N.N., K.G.L., R.M.R., G.T.) and Department of Pharmaceutical Sciences (R.G., D.M.D.), University of Tennessee Health Science Center, Memphis, Tennessee; Department of Biochemistry and Medical Chemistry, University of Pécs, Pécs, Hungary (G.N.K., B.S.); Department of Medicine, Section of Hematology/Oncology, Baylor College of Medicine, Houston, Texas (F.-T.L.); and Computational Research on Materials Institute, Department of Chemistry, University of Memphis, Tennessee (A.L.P.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Nóra Nusser
Department of Physiology (G.N.K., J.I.F., S.-C.L., J.L., N.N., K.G.L., R.M.R., G.T.) and Department of Pharmaceutical Sciences (R.G., D.M.D.), University of Tennessee Health Science Center, Memphis, Tennessee; Department of Biochemistry and Medical Chemistry, University of Pécs, Pécs, Hungary (G.N.K., B.S.); Department of Medicine, Section of Hematology/Oncology, Baylor College of Medicine, Houston, Texas (F.-T.L.); and Computational Research on Materials Institute, Department of Chemistry, University of Memphis, Tennessee (A.L.P.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Keng G. Lim
Department of Physiology (G.N.K., J.I.F., S.-C.L., J.L., N.N., K.G.L., R.M.R., G.T.) and Department of Pharmaceutical Sciences (R.G., D.M.D.), University of Tennessee Health Science Center, Memphis, Tennessee; Department of Biochemistry and Medical Chemistry, University of Pécs, Pécs, Hungary (G.N.K., B.S.); Department of Medicine, Section of Hematology/Oncology, Baylor College of Medicine, Houston, Texas (F.-T.L.); and Computational Research on Materials Institute, Department of Chemistry, University of Memphis, Tennessee (A.L.P.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ramesh M. Ray
Department of Physiology (G.N.K., J.I.F., S.-C.L., J.L., N.N., K.G.L., R.M.R., G.T.) and Department of Pharmaceutical Sciences (R.G., D.M.D.), University of Tennessee Health Science Center, Memphis, Tennessee; Department of Biochemistry and Medical Chemistry, University of Pécs, Pécs, Hungary (G.N.K., B.S.); Department of Medicine, Section of Hematology/Oncology, Baylor College of Medicine, Houston, Texas (F.-T.L.); and Computational Research on Materials Institute, Department of Chemistry, University of Memphis, Tennessee (A.L.P.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Fang-Tsyr Lin
Department of Physiology (G.N.K., J.I.F., S.-C.L., J.L., N.N., K.G.L., R.M.R., G.T.) and Department of Pharmaceutical Sciences (R.G., D.M.D.), University of Tennessee Health Science Center, Memphis, Tennessee; Department of Biochemistry and Medical Chemistry, University of Pécs, Pécs, Hungary (G.N.K., B.S.); Department of Medicine, Section of Hematology/Oncology, Baylor College of Medicine, Houston, Texas (F.-T.L.); and Computational Research on Materials Institute, Department of Chemistry, University of Memphis, Tennessee (A.L.P.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Abby L. Parrill
Department of Physiology (G.N.K., J.I.F., S.-C.L., J.L., N.N., K.G.L., R.M.R., G.T.) and Department of Pharmaceutical Sciences (R.G., D.M.D.), University of Tennessee Health Science Center, Memphis, Tennessee; Department of Biochemistry and Medical Chemistry, University of Pécs, Pécs, Hungary (G.N.K., B.S.); Department of Medicine, Section of Hematology/Oncology, Baylor College of Medicine, Houston, Texas (F.-T.L.); and Computational Research on Materials Institute, Department of Chemistry, University of Memphis, Tennessee (A.L.P.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Balázs Sümegi
Department of Physiology (G.N.K., J.I.F., S.-C.L., J.L., N.N., K.G.L., R.M.R., G.T.) and Department of Pharmaceutical Sciences (R.G., D.M.D.), University of Tennessee Health Science Center, Memphis, Tennessee; Department of Biochemistry and Medical Chemistry, University of Pécs, Pécs, Hungary (G.N.K., B.S.); Department of Medicine, Section of Hematology/Oncology, Baylor College of Medicine, Houston, Texas (F.-T.L.); and Computational Research on Materials Institute, Department of Chemistry, University of Memphis, Tennessee (A.L.P.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Duane D. Miller
Department of Physiology (G.N.K., J.I.F., S.-C.L., J.L., N.N., K.G.L., R.M.R., G.T.) and Department of Pharmaceutical Sciences (R.G., D.M.D.), University of Tennessee Health Science Center, Memphis, Tennessee; Department of Biochemistry and Medical Chemistry, University of Pécs, Pécs, Hungary (G.N.K., B.S.); Department of Medicine, Section of Hematology/Oncology, Baylor College of Medicine, Houston, Texas (F.-T.L.); and Computational Research on Materials Institute, Department of Chemistry, University of Memphis, Tennessee (A.L.P.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Gabor Tigyi
Department of Physiology (G.N.K., J.I.F., S.-C.L., J.L., N.N., K.G.L., R.M.R., G.T.) and Department of Pharmaceutical Sciences (R.G., D.M.D.), University of Tennessee Health Science Center, Memphis, Tennessee; Department of Biochemistry and Medical Chemistry, University of Pécs, Pécs, Hungary (G.N.K., B.S.); Department of Medicine, Section of Hematology/Oncology, Baylor College of Medicine, Houston, Texas (F.-T.L.); and Computational Research on Materials Institute, Department of Chemistry, University of Memphis, Tennessee (A.L.P.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF
Loading

Article Information

vol. 82 no. 6 1162-1173
DOI 
https://doi.org/10.1124/mol.112.079699
PubMed 
22968304

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received April 29, 2012
  • Accepted September 10, 2012
  • Published online November 14, 2012.

Article Versions

  • Earlier version (September 11, 2012 - 08:58).
  • Earlier version (September 12, 2012 - 07:46).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2012 The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Gyöngyi N. Kiss,
  2. James I. Fells,
  3. Renuka Gupte,
  4. Sue-Chin Lee,
  5. Jianxiong Liu,
  6. Nóra Nusser,
  7. Keng G. Lim,
  8. Ramesh M. Ray,
  9. Fang-Tsyr Lin,
  10. Abby L. Parrill,
  11. Balázs Sümegi,
  12. Duane D. Miller, and
  13. Gabor Tigyi
  1. Department of Physiology (G.N.K., J.I.F., S.-C.L., J.L., N.N., K.G.L., R.M.R., G.T.) and Department of Pharmaceutical Sciences (R.G., D.M.D.), University of Tennessee Health Science Center, Memphis, Tennessee; Department of Biochemistry and Medical Chemistry, University of Pécs, Pécs, Hungary (G.N.K., B.S.); Department of Medicine, Section of Hematology/Oncology, Baylor College of Medicine, Houston, Texas (F.-T.L.); and Computational Research on Materials Institute, Department of Chemistry, University of Memphis, Tennessee (A.L.P.)
  1. Address correspondence to:
    Dr. Gabor Tigyi, Department of Physiology, UTHSC, 894 Union Ave., Memphis TN 38163. E-mail: gtigyi{at}uthsc.edu
View Full Text

Statistics from Altmetric.com

Article usage

Article usage: September 2012 to April 2021

AbstractFullPdf
Sep 2012231077
Oct 201285087
Nov 20122631561
Dec 2012199748
Jan 20132211836
Feb 2013871027
Mar 201339416
Apr 2013581212
May 2013512026
Jun 2013321213
Jul 201366922
Aug 2013241212
Sep 201346816
Oct 201314519
Nov 2013231310
Dec 201322617
Jan 2014191515
Feb 2014373525
Mar 2014483030
Apr 2014493223
May 2014171925
Jun 201411913
Jul 2014191611
Aug 20141277
Sep 201417910
Oct 2014221419
Nov 20141957
Dec 2014191322
Jan 201536918
Feb 201541819
Mar 201544914
Apr 201523811
May 201537912
Jun 2015161710
Jul 2015361020
Aug 201530249
Sep 2015262412
Oct 2015161111
Nov 20151427
Dec 201527510
Jan 2016391219
Feb 201621916
Mar 201621625
Apr 201631614
May 201621316
Jun 201626219
Jul 201640413
Aug 201631715
Sep 201629617
Oct 2016122912
Nov 201642522
Dec 201612130
Jan 20172308
Feb 20170348
Mar 201723110
Apr 201722612
May 201702715
Jun 201701711
Jul 201722115
Aug 201762512
Sep 201722812
Oct 20170246
Nov 20176257
Dec 20175187
Jan 20188213
Feb 20184178
Mar 201852411
Apr 201822812
May 201833015
Jun 201801314
Jul 20181132
Aug 20183123
Sep 201801011
Oct 20181188
Nov 201803214
Dec 20181517
Jan 20191100
Feb 20191533
Mar 20193217
Apr 20191507
May 20191346
Jun 20192419
Jul 20191723
Aug 20192925
Sep 20192011
Oct 20193526
Nov 20194815
Dec 20194318
Jan 20204158
Feb 20203121
Mar 20204316
Apr 20204514
May 20202211
Jun 20204664
Jul 20204323
Aug 20203111
Sep 20204303
Oct 20204003
Nov 202041515
Dec 20203614
Jan 20214229
Feb 202154711
Mar 20215729
Apr 20212103

PreviousNext
Back to top

In this issue

Molecular Pharmacology: 82 (6)
Molecular Pharmacology
Vol. 82, Issue 6
1 Dec 2012
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Index by author
  • Editorial Board (PDF)
  • Front Matter (PDF)
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for sharing this Molecular Pharmacology article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Virtual Screening for LPA2-Specific Agonists Identifies a Nonlipid Compound with Antiapoptotic Actions
(Your Name) has forwarded a page to you from Molecular Pharmacology
(Your Name) thought you would be interested in this article in Molecular Pharmacology.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Research ArticleArticle

Nonlipid LPA2-Specific Agonist with Antiapoptotic Action

Gyöngyi N. Kiss, James I. Fells, Renuka Gupte, Sue-Chin Lee, Jianxiong Liu, Nóra Nusser, Keng G. Lim, Ramesh M. Ray, Fang-Tsyr Lin, Abby L. Parrill, Balázs Sümegi, Duane D. Miller and Gabor Tigyi
Molecular Pharmacology December 1, 2012, 82 (6) 1162-1173; DOI: https://doi.org/10.1124/mol.112.079699

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Research ArticleArticle

Nonlipid LPA2-Specific Agonist with Antiapoptotic Action

Gyöngyi N. Kiss, James I. Fells, Renuka Gupte, Sue-Chin Lee, Jianxiong Liu, Nóra Nusser, Keng G. Lim, Ramesh M. Ray, Fang-Tsyr Lin, Abby L. Parrill, Balázs Sümegi, Duane D. Miller and Gabor Tigyi
Molecular Pharmacology December 1, 2012, 82 (6) 1162-1173; DOI: https://doi.org/10.1124/mol.112.079699
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Introduction
    • Materials and Methods
    • Results
    • Discussion
    • Authorship Contributions
    • Acknowledgments
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF

Related Articles

Cited By...

More in this TOC Section

  • 6-Methylflavone Blocks Bitterness of Tenofovir
  • Positive Allosteric Modulation of the mGlu5 Receptor
  • Correction of mutant CNGA3 channel trafficking defect
Show more Articles

Similar Articles

Advertisement
  • Home
  • Alerts
Facebook   Twitter   LinkedIn   RSS

Navigate

  • Current Issue
  • Fast Forward by date
  • Fast Forward by section
  • Latest Articles
  • Archive
  • Search for Articles
  • Feedback
  • ASPET

More Information

  • About Molecular Pharmacology
  • Editorial Board
  • Instructions to Authors
  • Submit a Manuscript
  • Customized Alerts
  • RSS Feeds
  • Subscriptions
  • Permissions
  • Terms & Conditions of Use

ASPET's Other Journals

  • Drug Metabolism and Disposition
  • Journal of Pharmacology and Experimental Therapeutics
  • Pharmacological Reviews
  • Pharmacology Research & Perspectives
ISSN 1521-0111 (Online)

Copyright © 2021 by the American Society for Pharmacology and Experimental Therapeutics