Research ArticleArticle
Virtual Screening for LPA2-Specific Agonists Identifies a Nonlipid Compound with Antiapoptotic Actions
Gyöngyi N. Kiss, James I. Fells, Renuka Gupte, Sue-Chin Lee, Jianxiong Liu, Nóra Nusser, Keng G. Lim, Ramesh M. Ray, Fang-Tsyr Lin, Abby L. Parrill, Balázs Sümegi, Duane D. Miller and Gabor Tigyi
Molecular Pharmacology December 2012, 82 (6) 1162-1173; DOI: https://doi.org/10.1124/mol.112.079699
Gyöngyi N. Kiss
Department of Physiology (G.N.K., J.I.F., S.-C.L., J.L., N.N., K.G.L., R.M.R., G.T.) and Department of Pharmaceutical Sciences (R.G., D.M.D.), University of Tennessee Health Science Center, Memphis, Tennessee; Department of Biochemistry and Medical Chemistry, University of Pécs, Pécs, Hungary (G.N.K., B.S.); Department of Medicine, Section of Hematology/Oncology, Baylor College of Medicine, Houston, Texas (F.-T.L.); and Computational Research on Materials Institute, Department of Chemistry, University of Memphis, Tennessee (A.L.P.)
James I. Fells
Department of Physiology (G.N.K., J.I.F., S.-C.L., J.L., N.N., K.G.L., R.M.R., G.T.) and Department of Pharmaceutical Sciences (R.G., D.M.D.), University of Tennessee Health Science Center, Memphis, Tennessee; Department of Biochemistry and Medical Chemistry, University of Pécs, Pécs, Hungary (G.N.K., B.S.); Department of Medicine, Section of Hematology/Oncology, Baylor College of Medicine, Houston, Texas (F.-T.L.); and Computational Research on Materials Institute, Department of Chemistry, University of Memphis, Tennessee (A.L.P.)
Renuka Gupte
Department of Physiology (G.N.K., J.I.F., S.-C.L., J.L., N.N., K.G.L., R.M.R., G.T.) and Department of Pharmaceutical Sciences (R.G., D.M.D.), University of Tennessee Health Science Center, Memphis, Tennessee; Department of Biochemistry and Medical Chemistry, University of Pécs, Pécs, Hungary (G.N.K., B.S.); Department of Medicine, Section of Hematology/Oncology, Baylor College of Medicine, Houston, Texas (F.-T.L.); and Computational Research on Materials Institute, Department of Chemistry, University of Memphis, Tennessee (A.L.P.)
Sue-Chin Lee
Department of Physiology (G.N.K., J.I.F., S.-C.L., J.L., N.N., K.G.L., R.M.R., G.T.) and Department of Pharmaceutical Sciences (R.G., D.M.D.), University of Tennessee Health Science Center, Memphis, Tennessee; Department of Biochemistry and Medical Chemistry, University of Pécs, Pécs, Hungary (G.N.K., B.S.); Department of Medicine, Section of Hematology/Oncology, Baylor College of Medicine, Houston, Texas (F.-T.L.); and Computational Research on Materials Institute, Department of Chemistry, University of Memphis, Tennessee (A.L.P.)
Jianxiong Liu
Department of Physiology (G.N.K., J.I.F., S.-C.L., J.L., N.N., K.G.L., R.M.R., G.T.) and Department of Pharmaceutical Sciences (R.G., D.M.D.), University of Tennessee Health Science Center, Memphis, Tennessee; Department of Biochemistry and Medical Chemistry, University of Pécs, Pécs, Hungary (G.N.K., B.S.); Department of Medicine, Section of Hematology/Oncology, Baylor College of Medicine, Houston, Texas (F.-T.L.); and Computational Research on Materials Institute, Department of Chemistry, University of Memphis, Tennessee (A.L.P.)
Nóra Nusser
Department of Physiology (G.N.K., J.I.F., S.-C.L., J.L., N.N., K.G.L., R.M.R., G.T.) and Department of Pharmaceutical Sciences (R.G., D.M.D.), University of Tennessee Health Science Center, Memphis, Tennessee; Department of Biochemistry and Medical Chemistry, University of Pécs, Pécs, Hungary (G.N.K., B.S.); Department of Medicine, Section of Hematology/Oncology, Baylor College of Medicine, Houston, Texas (F.-T.L.); and Computational Research on Materials Institute, Department of Chemistry, University of Memphis, Tennessee (A.L.P.)
Keng G. Lim
Department of Physiology (G.N.K., J.I.F., S.-C.L., J.L., N.N., K.G.L., R.M.R., G.T.) and Department of Pharmaceutical Sciences (R.G., D.M.D.), University of Tennessee Health Science Center, Memphis, Tennessee; Department of Biochemistry and Medical Chemistry, University of Pécs, Pécs, Hungary (G.N.K., B.S.); Department of Medicine, Section of Hematology/Oncology, Baylor College of Medicine, Houston, Texas (F.-T.L.); and Computational Research on Materials Institute, Department of Chemistry, University of Memphis, Tennessee (A.L.P.)
Ramesh M. Ray
Department of Physiology (G.N.K., J.I.F., S.-C.L., J.L., N.N., K.G.L., R.M.R., G.T.) and Department of Pharmaceutical Sciences (R.G., D.M.D.), University of Tennessee Health Science Center, Memphis, Tennessee; Department of Biochemistry and Medical Chemistry, University of Pécs, Pécs, Hungary (G.N.K., B.S.); Department of Medicine, Section of Hematology/Oncology, Baylor College of Medicine, Houston, Texas (F.-T.L.); and Computational Research on Materials Institute, Department of Chemistry, University of Memphis, Tennessee (A.L.P.)
Fang-Tsyr Lin
Department of Physiology (G.N.K., J.I.F., S.-C.L., J.L., N.N., K.G.L., R.M.R., G.T.) and Department of Pharmaceutical Sciences (R.G., D.M.D.), University of Tennessee Health Science Center, Memphis, Tennessee; Department of Biochemistry and Medical Chemistry, University of Pécs, Pécs, Hungary (G.N.K., B.S.); Department of Medicine, Section of Hematology/Oncology, Baylor College of Medicine, Houston, Texas (F.-T.L.); and Computational Research on Materials Institute, Department of Chemistry, University of Memphis, Tennessee (A.L.P.)
Abby L. Parrill
Department of Physiology (G.N.K., J.I.F., S.-C.L., J.L., N.N., K.G.L., R.M.R., G.T.) and Department of Pharmaceutical Sciences (R.G., D.M.D.), University of Tennessee Health Science Center, Memphis, Tennessee; Department of Biochemistry and Medical Chemistry, University of Pécs, Pécs, Hungary (G.N.K., B.S.); Department of Medicine, Section of Hematology/Oncology, Baylor College of Medicine, Houston, Texas (F.-T.L.); and Computational Research on Materials Institute, Department of Chemistry, University of Memphis, Tennessee (A.L.P.)
Balázs Sümegi
Department of Physiology (G.N.K., J.I.F., S.-C.L., J.L., N.N., K.G.L., R.M.R., G.T.) and Department of Pharmaceutical Sciences (R.G., D.M.D.), University of Tennessee Health Science Center, Memphis, Tennessee; Department of Biochemistry and Medical Chemistry, University of Pécs, Pécs, Hungary (G.N.K., B.S.); Department of Medicine, Section of Hematology/Oncology, Baylor College of Medicine, Houston, Texas (F.-T.L.); and Computational Research on Materials Institute, Department of Chemistry, University of Memphis, Tennessee (A.L.P.)
Duane D. Miller
Department of Physiology (G.N.K., J.I.F., S.-C.L., J.L., N.N., K.G.L., R.M.R., G.T.) and Department of Pharmaceutical Sciences (R.G., D.M.D.), University of Tennessee Health Science Center, Memphis, Tennessee; Department of Biochemistry and Medical Chemistry, University of Pécs, Pécs, Hungary (G.N.K., B.S.); Department of Medicine, Section of Hematology/Oncology, Baylor College of Medicine, Houston, Texas (F.-T.L.); and Computational Research on Materials Institute, Department of Chemistry, University of Memphis, Tennessee (A.L.P.)
Gabor Tigyi
Department of Physiology (G.N.K., J.I.F., S.-C.L., J.L., N.N., K.G.L., R.M.R., G.T.) and Department of Pharmaceutical Sciences (R.G., D.M.D.), University of Tennessee Health Science Center, Memphis, Tennessee; Department of Biochemistry and Medical Chemistry, University of Pécs, Pécs, Hungary (G.N.K., B.S.); Department of Medicine, Section of Hematology/Oncology, Baylor College of Medicine, Houston, Texas (F.-T.L.); and Computational Research on Materials Institute, Department of Chemistry, University of Memphis, Tennessee (A.L.P.)
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Research ArticleArticle
Nonlipid LPA2-Specific Agonist with Antiapoptotic Action
Gyöngyi N. Kiss, James I. Fells, Renuka Gupte, Sue-Chin Lee, Jianxiong Liu, Nóra Nusser, Keng G. Lim, Ramesh M. Ray, Fang-Tsyr Lin, Abby L. Parrill, Balázs Sümegi, Duane D. Miller and Gabor Tigyi
Molecular Pharmacology December 1, 2012, 82 (6) 1162-1173; DOI: https://doi.org/10.1124/mol.112.079699
Research ArticleArticle
Nonlipid LPA2-Specific Agonist with Antiapoptotic Action
Gyöngyi N. Kiss, James I. Fells, Renuka Gupte, Sue-Chin Lee, Jianxiong Liu, Nóra Nusser, Keng G. Lim, Ramesh M. Ray, Fang-Tsyr Lin, Abby L. Parrill, Balázs Sümegi, Duane D. Miller and Gabor Tigyi
Molecular Pharmacology December 1, 2012, 82 (6) 1162-1173; DOI: https://doi.org/10.1124/mol.112.079699
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