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Research ArticleArticle

BET Bromodomain Proteins Mediate Downstream Signaling Events following Growth Factor Stimulation in Human Lung Fibroblasts and Are Involved in Bleomycin-Induced Pulmonary Fibrosis

Xiaoyan Tang, Ruoqi Peng, Yonglin Ren, Subramanium Apparsundaram, Jeremy Deguzman, Carla M. Bauer, Ann F. Hoffman, Shannon Hamilton, Zhenmin Liang, Hang Zeng, Maria E. Fuentes, Julie A. DeMartino, Christopher Kitson, Christopher S. Stevenson and David C. Budd
Molecular Pharmacology January 2013, 83 (1) 283-293; DOI: https://doi.org/10.1124/mol.112.081661
Xiaoyan Tang
Inflammation Discovery Therapeutic Area (X.T., R.P., Y.R., S.A., J.D., C.M.B., M.E.F., J.A.D., C.K., C.S.S., D.C.B.); Early ADME (DMPK) (Z.L., H.Z.); RDT–Discovery Technologies (A.F.H., S.H.); Hoffmann-La Roche Inc., Nutley, New Jersey
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Ruoqi Peng
Inflammation Discovery Therapeutic Area (X.T., R.P., Y.R., S.A., J.D., C.M.B., M.E.F., J.A.D., C.K., C.S.S., D.C.B.); Early ADME (DMPK) (Z.L., H.Z.); RDT–Discovery Technologies (A.F.H., S.H.); Hoffmann-La Roche Inc., Nutley, New Jersey
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Yonglin Ren
Inflammation Discovery Therapeutic Area (X.T., R.P., Y.R., S.A., J.D., C.M.B., M.E.F., J.A.D., C.K., C.S.S., D.C.B.); Early ADME (DMPK) (Z.L., H.Z.); RDT–Discovery Technologies (A.F.H., S.H.); Hoffmann-La Roche Inc., Nutley, New Jersey
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Subramanium Apparsundaram
Inflammation Discovery Therapeutic Area (X.T., R.P., Y.R., S.A., J.D., C.M.B., M.E.F., J.A.D., C.K., C.S.S., D.C.B.); Early ADME (DMPK) (Z.L., H.Z.); RDT–Discovery Technologies (A.F.H., S.H.); Hoffmann-La Roche Inc., Nutley, New Jersey
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Jeremy Deguzman
Inflammation Discovery Therapeutic Area (X.T., R.P., Y.R., S.A., J.D., C.M.B., M.E.F., J.A.D., C.K., C.S.S., D.C.B.); Early ADME (DMPK) (Z.L., H.Z.); RDT–Discovery Technologies (A.F.H., S.H.); Hoffmann-La Roche Inc., Nutley, New Jersey
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Carla M. Bauer
Inflammation Discovery Therapeutic Area (X.T., R.P., Y.R., S.A., J.D., C.M.B., M.E.F., J.A.D., C.K., C.S.S., D.C.B.); Early ADME (DMPK) (Z.L., H.Z.); RDT–Discovery Technologies (A.F.H., S.H.); Hoffmann-La Roche Inc., Nutley, New Jersey
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Ann F. Hoffman
Inflammation Discovery Therapeutic Area (X.T., R.P., Y.R., S.A., J.D., C.M.B., M.E.F., J.A.D., C.K., C.S.S., D.C.B.); Early ADME (DMPK) (Z.L., H.Z.); RDT–Discovery Technologies (A.F.H., S.H.); Hoffmann-La Roche Inc., Nutley, New Jersey
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Shannon Hamilton
Inflammation Discovery Therapeutic Area (X.T., R.P., Y.R., S.A., J.D., C.M.B., M.E.F., J.A.D., C.K., C.S.S., D.C.B.); Early ADME (DMPK) (Z.L., H.Z.); RDT–Discovery Technologies (A.F.H., S.H.); Hoffmann-La Roche Inc., Nutley, New Jersey
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Zhenmin Liang
Inflammation Discovery Therapeutic Area (X.T., R.P., Y.R., S.A., J.D., C.M.B., M.E.F., J.A.D., C.K., C.S.S., D.C.B.); Early ADME (DMPK) (Z.L., H.Z.); RDT–Discovery Technologies (A.F.H., S.H.); Hoffmann-La Roche Inc., Nutley, New Jersey
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Hang Zeng
Inflammation Discovery Therapeutic Area (X.T., R.P., Y.R., S.A., J.D., C.M.B., M.E.F., J.A.D., C.K., C.S.S., D.C.B.); Early ADME (DMPK) (Z.L., H.Z.); RDT–Discovery Technologies (A.F.H., S.H.); Hoffmann-La Roche Inc., Nutley, New Jersey
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Maria E. Fuentes
Inflammation Discovery Therapeutic Area (X.T., R.P., Y.R., S.A., J.D., C.M.B., M.E.F., J.A.D., C.K., C.S.S., D.C.B.); Early ADME (DMPK) (Z.L., H.Z.); RDT–Discovery Technologies (A.F.H., S.H.); Hoffmann-La Roche Inc., Nutley, New Jersey
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Julie A. DeMartino
Inflammation Discovery Therapeutic Area (X.T., R.P., Y.R., S.A., J.D., C.M.B., M.E.F., J.A.D., C.K., C.S.S., D.C.B.); Early ADME (DMPK) (Z.L., H.Z.); RDT–Discovery Technologies (A.F.H., S.H.); Hoffmann-La Roche Inc., Nutley, New Jersey
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Christopher Kitson
Inflammation Discovery Therapeutic Area (X.T., R.P., Y.R., S.A., J.D., C.M.B., M.E.F., J.A.D., C.K., C.S.S., D.C.B.); Early ADME (DMPK) (Z.L., H.Z.); RDT–Discovery Technologies (A.F.H., S.H.); Hoffmann-La Roche Inc., Nutley, New Jersey
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Christopher S. Stevenson
Inflammation Discovery Therapeutic Area (X.T., R.P., Y.R., S.A., J.D., C.M.B., M.E.F., J.A.D., C.K., C.S.S., D.C.B.); Early ADME (DMPK) (Z.L., H.Z.); RDT–Discovery Technologies (A.F.H., S.H.); Hoffmann-La Roche Inc., Nutley, New Jersey
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David C. Budd
Inflammation Discovery Therapeutic Area (X.T., R.P., Y.R., S.A., J.D., C.M.B., M.E.F., J.A.D., C.K., C.S.S., D.C.B.); Early ADME (DMPK) (Z.L., H.Z.); RDT–Discovery Technologies (A.F.H., S.H.); Hoffmann-La Roche Inc., Nutley, New Jersey
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Article Information

vol. 83 no. 1 283-293
DOI 
https://doi.org/10.1124/mol.112.081661
PubMed 
23115324

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received August 16, 2012
  • Accepted October 23, 2012
  • Published online December 20, 2012.

Article Versions

  • Earlier version (October 31, 2012 - 07:28).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2013 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Xiaoyan Tang,
  2. Ruoqi Peng,
  3. Yonglin Ren,
  4. Subramanium Apparsundaram,
  5. Jeremy Deguzman,
  6. Carla M. Bauer,
  7. Ann F. Hoffman,
  8. Shannon Hamilton,
  9. Zhenmin Liang,
  10. Hang Zeng,
  11. Maria E. Fuentes,
  12. Julie A. DeMartino,
  13. Christopher Kitson,
  14. Christopher S. Stevenson, and
  15. David C. Budd
  1. Inflammation Discovery Therapeutic Area (X.T., R.P., Y.R., S.A., J.D., C.M.B., M.E.F., J.A.D., C.K., C.S.S., D.C.B.); Early ADME (DMPK) (Z.L., H.Z.); RDT–Discovery Technologies (A.F.H., S.H.); Hoffmann-La Roche Inc., Nutley, New Jersey
  1. Address correspondence to:
    Dr. David C. Budd, Inflammation Discovery Therapeutic Area, Hoffmann-La Roche Inc., 340 Kingsland Street, Nutley, NJ 07110-1199. E-mail: david.budd{at}roche.com, daviebudd{at}hotmail.com
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Molecular Pharmacology: 83 (1)
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Research ArticleArticle

Brd Proteins Mediate Lung Fibrosis

Xiaoyan Tang, Ruoqi Peng, Yonglin Ren, Subramanium Apparsundaram, Jeremy Deguzman, Carla M. Bauer, Ann F. Hoffman, Shannon Hamilton, Zhenmin Liang, Hang Zeng, Maria E. Fuentes, Julie A. DeMartino, Christopher Kitson, Christopher S. Stevenson and David C. Budd
Molecular Pharmacology January 1, 2013, 83 (1) 283-293; DOI: https://doi.org/10.1124/mol.112.081661

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Research ArticleArticle

Brd Proteins Mediate Lung Fibrosis

Xiaoyan Tang, Ruoqi Peng, Yonglin Ren, Subramanium Apparsundaram, Jeremy Deguzman, Carla M. Bauer, Ann F. Hoffman, Shannon Hamilton, Zhenmin Liang, Hang Zeng, Maria E. Fuentes, Julie A. DeMartino, Christopher Kitson, Christopher S. Stevenson and David C. Budd
Molecular Pharmacology January 1, 2013, 83 (1) 283-293; DOI: https://doi.org/10.1124/mol.112.081661
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