Molecular Pharmacology: 83 (2)

February 01, 2013; Volume 83,Issue 2

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Kainate Receptor Signaling in Pain Pathways
Sonia K. Bhangoo and Geoffrey T. Swanson

Molecular Pharmacology February 2013, 83 (2) 307-315; DOI: https://doi.org/10.1124/mol.112.081398

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Sphingosine 1-Phosphate Receptor 1 (S1P₁) Upregulation and Amelioration of Experimental Autoimmune Encephalomyelitis by an S1P₁ Antagonist
Stuart M. Cahalan, Pedro J. Gonzalez-Cabrera, Nhan Nguyen, Miguel Guerrero, Elizabeth A. George Cisar, Nora B. Leaf, Steven J. Brown, Edward Roberts and Hugh Rosen

Molecular Pharmacology February 2013, 83 (2) 316-321; DOI: https://doi.org/10.1124/mol.112.082958

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CB₁ Receptor Allosteric Modulators Display Both Agonist and Signaling Pathway Specificity
Gemma L. Baillie, James G. Horswill, Sharon Anavi-Goffer, Patricia H. Reggio, Daniele Bolognini, Mary E. Abood, Sean McAllister, Phillip G. Strange, Gary J. Stephens, Roger G. Pertwee and Ruth A. Ross

Molecular Pharmacology February 2013, 83 (2) 322-338; DOI: https://doi.org/10.1124/mol.112.080879
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Enhanced Degradation of Dihydrofolate Reductase through Inhibition of NAD Kinase by Nicotinamide Analogs
Yi-Ching Hsieh, Philip Tedeschi, Rialnat AdeBisi Lawal, Debabrata Banerjee, Kathleen Scotto, John E. Kerrigan, Kuo-Chieh Lee, Nadine Johnson-Farley, Joseph R. Bertino and Emine Ercikan Abali

Molecular Pharmacology February 2013, 83 (2) 339-353; DOI: https://doi.org/10.1124/mol.112.080218
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Noncompetitive, Voltage-Dependent NMDA Receptor Antagonism by Hydrophobic Anions
Andrew J. Linsenbardt, Mariangela Chisari, Andrew Yu, Hong-Jin Shu, Charles F. Zorumski and Steven Mennerick

Molecular Pharmacology February 2013, 83 (2) 354-366; DOI: https://doi.org/10.1124/mol.112.081794
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Obtusilactone B from Machilus Thunbergii Targets Barrier-to-Autointegration Factor to Treat Cancer
Wanil Kim, Ha-Na Lyu, Hyun-Sook Kwon, Ye Seul Kim, Kyung-Ha Lee, Do-Yeon Kim, Goutam Chakraborty, Kwan Yong Choi, Ho Sup Yoon and Kyong-Tai Kim

Molecular Pharmacology February 2013, 83 (2) 367-376; DOI: https://doi.org/10.1124/mol.112.082578
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Induction of Multidrug Resistance Transporter ABCG2 by Prolactin in Human Breast Cancer Cells
Alex Man Lai Wu, Pooja Dalvi, Xiaoli Lu, Mingdong Yang, David S. Riddick, Jason Matthews, Charles V. Clevenger, Douglas D. Ross, Patricia A. Harper and Shinya Ito

Molecular Pharmacology February 2013, 83 (2) 377-388; DOI: https://doi.org/10.1124/mol.112.082362
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Functional Characterization of Three Mouse Formyl Peptide Receptors
Hui-Qiong He, Dan Liao, Zhen-Guo Wang, Zhong-Li Wang, Hu-Chen Zhou, Ming-Wei Wang and Richard D. Ye

Molecular Pharmacology February 2013, 83 (2) 389-398; DOI: https://doi.org/10.1124/mol.112.081315
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MicroRNA-145 Post-transcriptionally Regulates the Expression and Function of P-glycoprotein in Intestinal Epithelial Cells
Kenji Ikemura, Misato Yamamoto, Saori Miyazaki, Hideki Mizutani, Takuya Iwamoto and Masahiro Okuda

Molecular Pharmacology February 2013, 83 (2) 399-405; DOI: https://doi.org/10.1124/mol.112.081844
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Molecular Dissection of Lubeluzole Use–Dependent Block of Voltage-Gated Sodium Channels Discloses New Therapeutic Potentials
Jean-François Desaphy, Roberta Carbonara, Teresa Costanza, Giovanni Lentini, Maria Maddalena Cavalluzzi, Claudio Bruno, Carlo Franchini and Diana Conte Camerino

Molecular Pharmacology February 2013, 83 (2) 406-415; DOI: https://doi.org/10.1124/mol.112.080804
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Conformational Dynamics of Kir3.1/Kir3.2 Channel Activation Via δ-Opioid Receptors
Melissa Richard-Lalonde, Karim Nagi, Nicolas Audet, Rory Sleno, Mohammad Amraei, Mireille Hogue, Gianfranco Balboni, Peter W. Schiller, Michel Bouvier, Terence E. Hébert and Graciela Pineyro

Molecular Pharmacology February 2013, 83 (2) 416-428; DOI: https://doi.org/10.1124/mol.112.081950
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Canonical Transient Receptor Channel 5 (TRPC5) and TRPC1/4 Contribute to Seizure and Excitotoxicity by Distinct Cellular Mechanisms
Kevin D. Phelan, U Thaung Shwe, Joel Abramowitz, Hong Wu, Sung W. Rhee, Matthew D. Howell, Paul E. Gottschall, Marc Freichel, Veit Flockerzi, Lutz Birnbaumer and Fang Zheng

Molecular Pharmacology February 2013, 83 (2) 429-438; DOI: https://doi.org/10.1124/mol.112.082271
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Pyrimidine Salvage in Trypanosoma brucei Bloodstream Forms and the Trypanocidal Action of Halogenated Pyrimidines
Juma A. M. Ali, Darren J. Creek, Karl Burgess, Harriet C. Allison, Mark C. Field, Pascal Mäser and Harry P. De Koning

Molecular Pharmacology February 2013, 83 (2) 439-453; DOI: https://doi.org/10.1124/mol.112.082321
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Targeting the Metastasis Suppressor, NDRG1, Using Novel Iron Chelators: Regulation of Stress Fiber-Mediated Tumor Cell Migration via Modulation of the ROCK1/pMLC2 Signaling Pathway
Jing Sun, Daohai Zhang, Ying Zheng, Qian Zhao, Minhua Zheng, Zaklina Kovacevic and Des R. Richardson

Molecular Pharmacology February 2013, 83 (2) 454-469; DOI: https://doi.org/10.1124/mol.112.083097
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Mechanism of the Antiproliferative Activity of Some Naphthalene Diimide G-Quadruplex Ligands
Sonja M. Hampel, Antonella Pepe, Karin M. Greulich-Bode, Sanjay V. Malhotra, Anthony P. Reszka, Sebastian Veith, Petra Boukamp and Stephen Neidle

Molecular Pharmacology February 2013, 83 (2) 470-480; DOI: https://doi.org/10.1124/mol.112.081075
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An Allosteric Mechanism for Drug Block of the Human Cardiac Potassium Channel KCNQ1
Tao Yang, Jarrod A. Smith, Brenda F. Leake, Charles R. Sanders, Jens Meiler and Dan M. Roden

Molecular Pharmacology February 2013, 83 (2) 481-489; DOI: https://doi.org/10.1124/mol.112.081513
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Identification of Transporters Associated with Etoposide Sensitivity of Stomach Cancer Cell Lines and Methotrexate Sensitivity of Breast Cancer Cell Lines by Quantitative Targeted Absolute Proteomics
Wataru Obuchi, Sumio Ohtsuki, Yasuo Uchida, Ken Ohmine, Takao Yamori and Tetsuya Terasaki

Molecular Pharmacology February 2013, 83 (2) 490-500; DOI: https://doi.org/10.1124/mol.112.081083
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Bisphenol A Inhibits Voltage-Activated Ca²⁺ Channels in Vitro: Mechanisms and Structural Requirements
André Deutschmann, Michael Hans, Rainer Meyer, Hanns Häberlein and Dieter Swandulla

Molecular Pharmacology February 2013, 83 (2) 501-511; DOI: https://doi.org/10.1124/mol.112.081372
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Modulation of μ-Opioid Receptor Signaling by RGS19 in SH-SY5Y Cells
Qin Wang and John R. Traynor

Molecular Pharmacology February 2013, 83 (2) 512-520; DOI: https://doi.org/10.1124/mol.112.081992
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Allosteric Modulation of a Chemogenetically Modified G Protein-Coupled Receptor
Alaa Abdul-Ridha, J. Robert Lane, Patrick M. Sexton, Meritxell Canals and Arthur Christopoulos

Molecular Pharmacology February 2013, 83 (2) 521-530; DOI: https://doi.org/10.1124/mol.112.083006
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A Novel Semisynthetic Inhibitor of the FRB Domain of Mammalian Target of Rapamycin Blocks Proliferation and Triggers Apoptosis in Chemoresistant Prostate Cancer Cells
Samy A. F. Morad, Maximilian Schmid, Berthold Büchele, Hans-Ullrich Siehl, Menna El Gaafary, Oleg Lunov, Tatiana Syrovets and Thomas Simmet

Molecular Pharmacology February 2013, 83 (2) 531-541; DOI: https://doi.org/10.1124/mol.112.081349
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Apomorphine Is a Bimodal Modulator of TRPA1 Channels
Anja Schulze, Beatrice Oehler, Nicole Urban, Michael Schaefer and Kerstin Hill

Molecular Pharmacology February 2013, 83 (2) 542-551; DOI: https://doi.org/10.1124/mol.112.081976
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Ticlopidine, a Cholestatic Liver Injury-Inducible Drug, Causes Dysfunction of Bile Formation via Diminished Biliary Secretion of Phospholipids: Involvement of Biliary-Excreted Glutathione-Conjugated Ticlopidine Metabolites
Takashi Yoshikado, Tappei Takada, Hideaki Yamamoto, Jeng Kae Tan, Kousei Ito, Tomofumi Santa and Hiroshi Suzuki

Molecular Pharmacology February 2013, 83 (2) 552-562; DOI: https://doi.org/10.1124/mol.112.081752

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