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Research ArticleArticle

Pyrimidine Salvage in Trypanosoma brucei Bloodstream Forms and the Trypanocidal Action of Halogenated Pyrimidines

Juma A. M. Ali, Darren J. Creek, Karl Burgess, Harriet C. Allison, Mark C. Field, Pascal Mäser and Harry P. De Koning
Molecular Pharmacology February 2013, 83 (2) 439-453; DOI: https://doi.org/10.1124/mol.112.082321
Juma A. M. Ali
Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom (J.A.M.A., D.J.C., K.B., H.P.d.K.); Al Jabal Al Gharbi University, Gharyan, Libya (J.A.M.A.); Department of Biochemistry and Molecular Biology, University of Melbourne, Parkville, Victoria, Australia (D.J.C.); Department of Pathology, University of Cambridge, Cambridge, United Kingdom (H.C.A., M.C.F.); and Swiss Tropical and Public Health Institute, University of Basel, Basel, Switzerland (P.M.)
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Darren J. Creek
Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom (J.A.M.A., D.J.C., K.B., H.P.d.K.); Al Jabal Al Gharbi University, Gharyan, Libya (J.A.M.A.); Department of Biochemistry and Molecular Biology, University of Melbourne, Parkville, Victoria, Australia (D.J.C.); Department of Pathology, University of Cambridge, Cambridge, United Kingdom (H.C.A., M.C.F.); and Swiss Tropical and Public Health Institute, University of Basel, Basel, Switzerland (P.M.)
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Karl Burgess
Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom (J.A.M.A., D.J.C., K.B., H.P.d.K.); Al Jabal Al Gharbi University, Gharyan, Libya (J.A.M.A.); Department of Biochemistry and Molecular Biology, University of Melbourne, Parkville, Victoria, Australia (D.J.C.); Department of Pathology, University of Cambridge, Cambridge, United Kingdom (H.C.A., M.C.F.); and Swiss Tropical and Public Health Institute, University of Basel, Basel, Switzerland (P.M.)
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Harriet C. Allison
Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom (J.A.M.A., D.J.C., K.B., H.P.d.K.); Al Jabal Al Gharbi University, Gharyan, Libya (J.A.M.A.); Department of Biochemistry and Molecular Biology, University of Melbourne, Parkville, Victoria, Australia (D.J.C.); Department of Pathology, University of Cambridge, Cambridge, United Kingdom (H.C.A., M.C.F.); and Swiss Tropical and Public Health Institute, University of Basel, Basel, Switzerland (P.M.)
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Mark C. Field
Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom (J.A.M.A., D.J.C., K.B., H.P.d.K.); Al Jabal Al Gharbi University, Gharyan, Libya (J.A.M.A.); Department of Biochemistry and Molecular Biology, University of Melbourne, Parkville, Victoria, Australia (D.J.C.); Department of Pathology, University of Cambridge, Cambridge, United Kingdom (H.C.A., M.C.F.); and Swiss Tropical and Public Health Institute, University of Basel, Basel, Switzerland (P.M.)
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Pascal Mäser
Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom (J.A.M.A., D.J.C., K.B., H.P.d.K.); Al Jabal Al Gharbi University, Gharyan, Libya (J.A.M.A.); Department of Biochemistry and Molecular Biology, University of Melbourne, Parkville, Victoria, Australia (D.J.C.); Department of Pathology, University of Cambridge, Cambridge, United Kingdom (H.C.A., M.C.F.); and Swiss Tropical and Public Health Institute, University of Basel, Basel, Switzerland (P.M.)
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Harry P. De Koning
Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom (J.A.M.A., D.J.C., K.B., H.P.d.K.); Al Jabal Al Gharbi University, Gharyan, Libya (J.A.M.A.); Department of Biochemistry and Molecular Biology, University of Melbourne, Parkville, Victoria, Australia (D.J.C.); Department of Pathology, University of Cambridge, Cambridge, United Kingdom (H.C.A., M.C.F.); and Swiss Tropical and Public Health Institute, University of Basel, Basel, Switzerland (P.M.)
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Article Information

vol. 83 no. 2 439-453
DOI 
https://doi.org/10.1124/mol.112.082321
PubMed 
23188714

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received September 10, 2012
  • Accepted November 27, 2012
  • Published online January 17, 2013.

Article Versions

  • Earlier version (November 27, 2012 - 08:52).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2013 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Juma A. M. Ali,
  2. Darren J. Creek,
  3. Karl Burgess,
  4. Harriet C. Allison,
  5. Mark C. Field,
  6. Pascal Mäser, and
  7. Harry P. De Koning
  1. Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom (J.A.M.A., D.J.C., K.B., H.P.d.K.); Al Jabal Al Gharbi University, Gharyan, Libya (J.A.M.A.); Department of Biochemistry and Molecular Biology, University of Melbourne, Parkville, Victoria, Australia (D.J.C.); Department of Pathology, University of Cambridge, Cambridge, United Kingdom (H.C.A., M.C.F.); and Swiss Tropical and Public Health Institute, University of Basel, Basel, Switzerland (P.M.)
  1. Address correspondence to:
    Harry P. De Koning, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, Sir Graeme Davies Building, University of Glasgow, 120 University Place, Glasgow G12 8TA, United Kingdom. E-mail: Harry.de-Koning{at}glasgow.ac.uk
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Molecular Pharmacology: 83 (2)
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Research ArticleArticle

Pyrimidine Metabolism in Trypanosoma brucei

Juma A. M. Ali, Darren J. Creek, Karl Burgess, Harriet C. Allison, Mark C. Field, Pascal Mäser and Harry P. De Koning
Molecular Pharmacology February 1, 2013, 83 (2) 439-453; DOI: https://doi.org/10.1124/mol.112.082321

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Research ArticleArticle

Pyrimidine Metabolism in Trypanosoma brucei

Juma A. M. Ali, Darren J. Creek, Karl Burgess, Harriet C. Allison, Mark C. Field, Pascal Mäser and Harry P. De Koning
Molecular Pharmacology February 1, 2013, 83 (2) 439-453; DOI: https://doi.org/10.1124/mol.112.082321
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