Table of Contents

Articles

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  Somatic Mutations in GRM1 in Cancer Alter Metabotropic Glutamate Receptor 1 Intracellular Localization and Signaling

  Jessica L. Esseltine, Melinda D. Willard, Isabella H. Wulur, Mary E. Lajiness, Thomas D. Barber and Stephen S. G. Ferguson

  Molecular Pharmacology April 2013, 83 (4) 770-780; DOI: https://doi.org/10.1124/mol.112.081695
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  Protease-Activated Receptor (PAR) 1 and PAR4 Differentially Regulate Factor V Expression from Human Platelets

  Matthew Duvernay, Summer Young, David Gailani, Jonathan Schoenecker and Heidi E. Hamm

  Molecular Pharmacology April 2013, 83 (4) 781-792; DOI: https://doi.org/10.1124/mol.112.083477
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  Inhibitors of PI(4,5)P₂ Synthesis Reveal Dynamic Regulation of IgE Receptor Signaling by Phosphoinositides in RBL Mast Cells

  Marcela de Souza Santos, Rose Mary Zumstein Georgetto Naal, Barbara Baird and David Holowka

  Molecular Pharmacology April 2013, 83 (4) 793-804; DOI: https://doi.org/10.1124/mol.112.082834
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  ICA-105574 Interacts with a Common Binding Site to Elicit Opposite Effects on Inactivation Gating of EAG and ERG Potassium Channels

  Vivek Garg, Anna Stary-Weinzinger and Michael C. Sanguinetti

  Molecular Pharmacology April 2013, 83 (4) 805-813; DOI: https://doi.org/10.1124/mol.112.084384
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  Membrane Tethered Bursicon Constructs as Heterodimeric Modulators of the Drosophila G Protein–Coupled Receptor Rickets

  Benjamin N. Harwood, Jean-Philippe Fortin, Kevin Gao, Ci Chen, Martin Beinborn and Alan S. Kopin

  Molecular Pharmacology April 2013, 83 (4) 814-821; DOI: https://doi.org/10.1124/mol.112.081570
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  Differential Activation and Modulation of the Glucagon-Like Peptide-1 Receptor by Small Molecule Ligands

  Denise Wootten, Emilia E. Savage, Francis S. Willard, Ana B. Bueno, Kyle W. Sloop, Arthur Christopoulos and Patrick M. Sexton

  Molecular Pharmacology April 2013, 83 (4) 822-834; DOI: https://doi.org/10.1124/mol.112.084525
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  A Novel Metabotropic Glutamate Receptor 5 Positive Allosteric Modulator Acts at a Unique Site and Confers Stimulus Bias to mGlu5 Signaling

  M. J. Noetzel, K. J. Gregory, P. N. Vinson, J. T. Manka, S. R. Stauffer, C. W. Lindsley, C. M. Niswender, Z. Xiang and P. J. Conn

  Molecular Pharmacology April 2013, 83 (4) 835-847; DOI: https://doi.org/10.1124/mol.112.082891
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  Formation, Reactivity, and Antiplatelet Activity of Mixed Disulfide Conjugates of Clopidogrel

  Haoming Zhang, D. Adam Lauver, Benedict R. Lucchesi and Paul F. Hollenberg

  Molecular Pharmacology April 2013, 83 (4) 848-856; DOI: https://doi.org/10.1124/mol.112.084392
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  Lapatinib-Mediated Cyclooxygenase-2 Expression via Epidermal Growth Factor Receptor/HuR Interaction Enhances the Aggressiveness of Triple-Negative Breast Cancer Cells

  Te-Chun Hsia, Chih-Yen Tu, Yun-Ju Chen, Ya-Ling Wei, Meng-Chieh Yu, Sheng-Chie Hsu, Shing-Ling Tsai, Wen-Shu Chen, Ming-Hsin Yeh, Chia-Jui Yen, Yung-Luen Yu, Tzung-Chi Huang, Chih-Yang Huang, Mien-Chie Hung and Wei-Chien Huang

  Molecular Pharmacology April 2013, 83 (4) 857-869; DOI: https://doi.org/10.1124/mol.112.082743
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  Differential Phosphorylation, Desensitization, and Internalization of α1A−Adrenoceptors Activated by Norepinephrine and Oxymetazoline

  Juliana Akinaga, Vanessa Lima, Luiz Ricardo de Almeida Kiguti, Flávia Hebeler-Barbosa, Rocío Alcántara-Hernández, J. Adolfo García-Sáinz and André Sampaio Pupo

  Molecular Pharmacology April 2013, 83 (4) 870-881; DOI: https://doi.org/10.1124/mol.112.082313
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  A Receptor Tyrosine Kinase Network Composed of Fibroblast Growth Factor Receptors, Epidermal Growth Factor Receptor, v-erb-b2 Erythroblastic Leukemia Viral Oncogene Homolog 2, and Hepatocyte Growth Factor Receptor Drives Growth and Survival of Head and Neck Squamous Carcinoma Cell Lines

  Katherine R. Singleton, Jihye Kim, Trista K. Hinz, Lindsay A. Marek, Matias Casás-Selves, Clark Hatheway, Aik Choon Tan, James DeGregori and Lynn E. Heasley

  Molecular Pharmacology April 2013, 83 (4) 882-893; DOI: https://doi.org/10.1124/mol.112.084111
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  Phosphodiesterase 4 Inhibitors Augment the Ability of Formoterol to Enhance Glucocorticoid-Dependent Gene Transcription in Human Airway Epithelial Cells: A Novel Mechanism for the Clinical Efficacy of Roflumilast in Severe Chronic Obstructive Pulmonary Disease

  Thunicia Moodley, Sylvia M. Wilson, Taruna Joshi, Christopher F. Rider, Pawan Sharma, Dong Yan, Robert Newton and Mark A. Giembycz

  Molecular Pharmacology April 2013, 83 (4) 894-906; DOI: https://doi.org/10.1124/mol.112.083493