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Research ArticleArticle

Somatic Mutations in GRM1 in Cancer Alter Metabotropic Glutamate Receptor 1 Intracellular Localization and Signaling

Jessica L. Esseltine, Melinda D. Willard, Isabella H. Wulur, Mary E. Lajiness, Thomas D. Barber and Stephen S. G. Ferguson
Molecular Pharmacology April 2013, 83 (4) 770-780; DOI: https://doi.org/10.1124/mol.112.081695
Jessica L. Esseltine
Molecular Brain Research Group, Robarts Research Institute and Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada (J.L.E., S.S.G.F.); and Tailored Therapeutics, Eli Lilly and Company, Indianapolis, Indiana (M.D.W., I.H.W., M.E.H., T.D.B.)
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Melinda D. Willard
Molecular Brain Research Group, Robarts Research Institute and Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada (J.L.E., S.S.G.F.); and Tailored Therapeutics, Eli Lilly and Company, Indianapolis, Indiana (M.D.W., I.H.W., M.E.H., T.D.B.)
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Isabella H. Wulur
Molecular Brain Research Group, Robarts Research Institute and Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada (J.L.E., S.S.G.F.); and Tailored Therapeutics, Eli Lilly and Company, Indianapolis, Indiana (M.D.W., I.H.W., M.E.H., T.D.B.)
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Mary E. Lajiness
Molecular Brain Research Group, Robarts Research Institute and Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada (J.L.E., S.S.G.F.); and Tailored Therapeutics, Eli Lilly and Company, Indianapolis, Indiana (M.D.W., I.H.W., M.E.H., T.D.B.)
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Thomas D. Barber
Molecular Brain Research Group, Robarts Research Institute and Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada (J.L.E., S.S.G.F.); and Tailored Therapeutics, Eli Lilly and Company, Indianapolis, Indiana (M.D.W., I.H.W., M.E.H., T.D.B.)
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Stephen S. G. Ferguson
Molecular Brain Research Group, Robarts Research Institute and Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada (J.L.E., S.S.G.F.); and Tailored Therapeutics, Eli Lilly and Company, Indianapolis, Indiana (M.D.W., I.H.W., M.E.H., T.D.B.)
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Article Information

vol. 83 no. 4 770-780
DOI 
https://doi.org/10.1124/mol.112.081695
PubMed 
23303475

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received August 2, 2012
  • Accepted January 9, 2013
  • Published online March 19, 2013.

Article Versions

  • Earlier version (January 9, 2013 - 06:56).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2013 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Jessica L. Esseltine,
  2. Melinda D. Willard,
  3. Isabella H. Wulur,
  4. Mary E. Lajiness,
  5. Thomas D. Barber, and
  6. Stephen S. G. Ferguson
  1. Molecular Brain Research Group, Robarts Research Institute and Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada (J.L.E., S.S.G.F.); and Tailored Therapeutics, Eli Lilly and Company, Indianapolis, Indiana (M.D.W., I.H.W., M.E.H., T.D.B.)
  1. Address correspondence to:
    Dr. S. S. G. Ferguson, Robarts Research Institute, University of Western Ontario, 100 Perth Dr., London, Ontario, Canada, N6A 5K8. E-mail: ferguson{at}robarts.ca
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Molecular Pharmacology: 83 (4)
Molecular Pharmacology
Vol. 83, Issue 4
1 Apr 2013
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Research ArticleArticle

Somatic Mutations in GRM1 Alter Receptor Activity

Jessica L. Esseltine, Melinda D. Willard, Isabella H. Wulur, Mary E. Lajiness, Thomas D. Barber and Stephen S. G. Ferguson
Molecular Pharmacology April 1, 2013, 83 (4) 770-780; DOI: https://doi.org/10.1124/mol.112.081695

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Research ArticleArticle

Somatic Mutations in GRM1 Alter Receptor Activity

Jessica L. Esseltine, Melinda D. Willard, Isabella H. Wulur, Mary E. Lajiness, Thomas D. Barber and Stephen S. G. Ferguson
Molecular Pharmacology April 1, 2013, 83 (4) 770-780; DOI: https://doi.org/10.1124/mol.112.081695
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